Cell-free freeze-dried synthetic biology for wearable biotechnology applications

Synthetic biology aims to develop modular genetic networks for computation, sensing, and control of biological systems, holding great promise for next-generation biosensing platforms. Similarly, advances in material sciences have allowed for the design of substrates and textiles engineered to exhibit novel mechanical, electrical, and optical properties for sensing and actuation. Wearable biosensors using synthetic biology principles and smart materials could expand on this potential, especially as solutions for continuous, fine-grained monitoring of physiological status, disease states, and pathogen/toxin exposure difficult to assess with other methods. Despite this, only few examples of synthetic biology sensors compatible with wearable use-cases have been described, all of which rely on the use of live engineered bacteria with sustainment limitations.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Mechanical Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2020

Author dc:creator

• Soenksen Martinez, Luis Rubén.

Advisor dc:contributor.advisor

• James J. Collins.

• Mechanical Engineering.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/127730

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/127730