Rational hydrogel design for point-of-care bioassays

As the global disease burden shifts increasingly towards chronic diseases, there is a need for improved diagnosis and monitoring so that patients can get the care they need. This is particularly evident in the developing world, where many people live far from diagnostic laboratories. Point-of-care diagnostics are tests that can be run in doctor's offices, clinics, and in patient homes. These tests must be rapid, so that they can be run quickly while the patient waits for results. Established point-of-care technologies are largely centered on lateral flow assays. Hydrogel microparticles have been used extensively for bioassays due to their nonfouling nature and ability to be functionalized with different types of biomolecules. Here, we use polyethylene glycol hydrogel particles to develop point-of-care bioassays. We focus on two different biomarkers: proteins and microRNA.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Chemical Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2019

Author dc:creator

• Shapiro, Sarah Jane,1991-

Advisor dc:contributor.advisor

• Patrick S. Doyle.

• Chemical Engineering.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/127714

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/127714