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Showing 1 to 20 of 292 for “"Bioassays"”.
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Rational hydrogel design for point-of-care bioassays
… microparticles have been used extensively for bioassays due to their nonfouling nature and ability to be functionalized with different types of biomolecules. Here, we use polyethylene glycol hydrogel particles to develop point-of-care bioassays. We focus on two different biomarkers: proteins …
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Synthesis and Applications of Luminescent Quantum Dots in Bioassays
… for optical imaging of cells, tissues and in bioassays as alternatives to conventional organic fluorophores. The main objective of my PhD dissertation was to develop luminescent quantum dot based bioassays for real time monitoring of enzyme activity and simultaneous detection of several …
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Biomonitoring an Impacted Stream Using Benthic Macroinvertebrates and Bioassays
… biomonitoring and single-species bioassays to monitor water quality in Wilson's Creek, Springfield, MO, for the 2-year period January 1993-December 1994. Wilson's Creek was potentially impacted by increased urbanization, agricultural run-off, and several facilities permitted to …
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Studies of Bioactive Natural Products and Mechanism-Based Bioassays
An extract of the sponge <i>Rhabdastrella globostellifera</i> was active in an assay measuring stabilization of the binding of DNA with DNA polymerase β. From this extract, four isomalabaricane triterpenoids were isolated and characterized, three of which were active in the binding assay. All …
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Synthesis, Characterization, and Application of Metal-chelating Polymers for Mass Cytometric Bioassays
… of metal-chelating polymers for mass-cytometric bioassays. Mass cytometry is a cell characterization technique in which cells are injected individually into an ICP-MS detector. Signal is provided by staining cell-surface or intracellular antigens with metal-labeled antibodies (Abs). These Abs are …
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Development of Bioassays Based on Nucleic Acid Amplification and Next-Generation Sequencing
Adulteration and mis-labeling of honey to mask its true origin have become a global concern. Pollen microscopy, the current gold standard for identifying the geographical origins of honey, is very laborious and requires extensive training. In addition, filtered honey cannot be identified by pollen …
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Sociogenetic investigation of the southern harvester termite, Microhodotermes viator, via genetic and behavioural bioassays
This thesis presents the first investigation of the population structure of the southern harvester termite, Microhodotermes viator (Family: Hodotermitidae), by assessing the genetic state and behavioural interactions within and between twelve colonies, from four areas across the Western Cape of …
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Methionine bioassays and methionine-choline-sulfate relationships in practical-type diets for young turkeys
Two experiments were conducted with a total of 1,728 Large White turkeys to determine the relative potencies of four methionine compounds on an equimolar basis. A 28% protein basal diet composed primarily of ground yellow corn, dehulled soybean meal, and meat and bone meal was supplemented with …
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Predicting the bioavailability and toxicity of hydrophobic pesticides using bioassays and a solid phase microextraction approach
Pesticides are unique chemical stressors in that they are designed to have biological activity and are intentionally released into the environment in large quantities. Although the use of pesticides has resulted in effective pest control and increased crop production, pesticide use has caused …
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Techniques for Evaluating Power Plant Discharges Using In-Situ Breakdown and Flow Though Laboratory Sediment Bioassays
… (Corbicula fluminea) to sediments in 10-day bioassays. These organisms had acceptable survivorship in the controls (>70%), excellent recovery of all exposed organisms (97.5%) and were sensitive to copper-spiked sediments. Comparitive sensitivity of this age class demonstrated them to be …
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Validation of the Planarian Bioassay With Defined Mixtures and Testing Against Other Bioassays With Contaminated Samples From Pakistan
… the sensitivity of the planarian model and other bioassays to contaminated environmental samples and, in turn, assess the toxicity of the contaminants in the samples.
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Natürliche Lebensmittelinhaltsstoffe als Liganden des Ah Rezeptors - Identifizierung und Charakterisierung von Beta-Carbolinen mit AhR Ligandenpotential mittels funktioneller Bioassays
… anhand von funktionellen AhR-abhängigen Bioassays stand die Klasse der ß-Carboline und ihrer Derivate, deren natürliches Vorkommen bereits in zahlreichen Lebensmitteln und im menschlichen Organismus beschrieben ist. Die ß-Carboline wurden für die Untersuchung auf ihr mögliches AhR …
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Evaluation of Metabolic Endpoints for Use as Biomarkers of Exposure to Environmental Estrogens and in Bioassays of Their Activity
These findings indicate that angiotensinogen and uterine complement C3 can serve as sensitive indicators of estrogenicity. Additionally, angiotensinogen has the potential to be a biomarker of exposure to estrogenic compounds because its measurement only requires a blood sample, while providing a …
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Optimization and Development of In Vitro Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid Receptor 2
… cancer, and many others. Developing in vitro bioassays to determine binding and functional activity of compounds has the ability to lead researchers to develop a safe and effective drug that may target the cannabinoid receptors. The objective is to display the therapeutic effects associated …
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Characterization of fungicide resistance in grape powdery and downy mildew using field trials, bioassays, genomic, and transcriptomic approaches: quinoxyfen, phosphite, and mandipropamid
… fungicides. A field trial and laboratory bioassays were conducted to determine whether P. viticola isolates from vineyards with suspected control failures showed reduced sensitivity against phosphite fungicides. Prophyt applied at 14-day intervals under high disease pressure provided poor …
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The Relationship of Herpetofaunal Community Composition to an Elephant (Loxodonta Africana) Modified Savanna Woodland of Northern Tanzania, and Bioassays with African Elephants
… the woodland area. In addition to this study, bioassays were conducted on three chemical compounds (cyclohexanone, 2<decanone and 2<nonanone) that could possibly be elephant pheromones. The compounds were tested from August 2007 - April 2008. The compounds were not significantly bioactive, but …
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Studies on the specificities of <i>In Vivo</i> and <i>In Vitro</i> bioassays used in the potency determination of Therapeutic Erythropoietin
… action. Current <i>in vitro</i> cell-based bioassays for Epo are unaffected by such a phenomenon and therefore do not correlate with the invivo bioassays.<br></br><br></br>As part of this project, strategies were devised for rendering cell-based bioassays sensitive to sialylation. The …
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Evaluation of Anaerobic Biodegradation of Organic Carbon Extracted from Aquifer Sediment
… has been tested in several series of aerobic bioassays to determine the biodegradable fraction of carbon extracted. This study seeks to show that the carbon removed from the sediment by this extraction process will also degrade in anaerobic environments. Three aquifer sediment samples …
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An Assessment of Perceived Crop Damage in a Tanzanian Village Impacted by Human-Elephant Conflict and an Investigation of Deterrent Properties of African Elephant (Loxodonta Africana) Exudates Using Bioassays
Human-elephant conflict (HEC) is on the rise in East Africa as habitat that was formerly occupied by elephants and other wildlife is being converted to farmland. African elephants (Loxodonta africana) will raid agricultural fields to feed on crops, and many agriculturalists attribute the majority …
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