Dynamic regulation and functions of locus-specific DNA methylation

The role and regulation of DNA methylation at various genetic elements have gathered tremendous interest over decades. The methylomes of many cell types have been described, revealing a dynamic and tissue-specific pattern of DNA methylation (tissue-specific differentially methylated regions, T-DMRs) in the distal regulatory elements, such as enhancers. The formation of T-DMRs still remain mysterious, however, one of their interesting features observed in mouse ES cells (mESCs) is the low-to-intermediate levels of average DNA methylation resulted from inter-cellular epigenetic heterogeneity. Given the transcriptional repressive role of DNA methylation at promoters, such non-zero levels of enhancer methylation is interesting to characterize.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Biology

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2020

Author dc:creator

• Song, Yuelin

Advisor dc:contributor.advisor

• Rudolf Jaenisch.

• Biology.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/127574

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/127574