Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 136 for “"Genetic elements"”.
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Evolutionary Fitness of Non-Coding Genetic Elements
… the evolutionary fitness of two classes of genetic elements, pseudogenes and exons, that may encode functional amino acid sequences. In Chapter 1 of this dissertation, we introduce the concepts and tools employed in later chapters. We provide a conceptual overview of pseudogenes and exons, …
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Interactions between mobile genetic elements and their bacterial hosts
Integrative and conjugative elements (ICEs) are widespread mobile genetic elements that facilitate the spread of many important genes, including those involved in antibiotic resistance, metabolism, pathogenesis, or symbiosis. These elements are also powerful tools for genetic analyses and …
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Mobile genetic elements in Coxiella burnetii: Friends, foes or just indifferent?
… burnetii contains a large number of mobile genetic elements including two group I introns and an intervening sequence (IVS) that interrupt the 23S rRNA gene; an intein within dnaB (encoding replicative DNA helicase) and a homing endonuclease. The introns are self-splicing ribozymes and able …
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Mobile genetic elements in Coxiella burnetii: Friends, foes or just indifferent?
… burnetii contains a large number of mobile genetic elements including two group I introns and an intervening sequence (IVS) that interrupt the 23S rRNA gene; an intein within dnaB (encoding replicative DNA helicase) and a homing endonuclease. The introns are self-splicing ribozymes and able …
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Mobile genetic elements as modulators of the human gut symbiont Bacteroides
Mobile genetic elements (MGEs) facilitate horizontal gene transfer (HGT) in all cellular hosts. In microbial systems, MGEs (e.g. phages, integrative and conjugative elements) are potent drivers of host evolution. Within hosts from the bacterial genus Bacteroides, one of the most common and abundant …
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Origin, Variation and Properties of the Genetic Elements Responsible for Transduction of the 'Lac' Characters
Made available in DSpace on 2014-12-05T21:45:35Z (GMT). No. of bitstreams: 1 6101672.pdf: 4448307 bytes, checksum: b81b09b91cfb3087d3f3ac04f4ffaa74 (MD5) Previous issue date: 1961
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Application of Single-Molecule Analytical Methods for the Characterization of Multimeric Genetic Elements in Yarrowia lipolytica DSM 3286
… examination via DNA sequencing of multimeric genetic elements or random integration events in production cell lines or in potential host genomes is a critical regulatory component in the assessment of potential health risks associated with therapeutic proteins and gene therapeutics. Current …
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Investigation of the prevalence and role of mobile genetic elements associated with an aminoglycoside resistance gene, aacC2a, in Acinetobacter baumannii
Includes abstract. Includes bibliographical references (leaves 115-141).
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Characterization of an exclusion mechanism in an integrative and conjugative element in Bacillus subtilis
… gene transfer is the acquisition of new genetic material that can confer novel phenotypes to bacteria and contribute to their evolution. Conjugation is an important mechanism of horizontal gene transfer that involves the direct transfer of DNA between two cells and is mediated by mobile …
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Phenotypic and genotypic characterization of salmonella isolates from chickens and humans in South Sudan.
… antimicrobial susceptibility profiles while the genetic diversity was determined through molecular typing methods that included the detection of virulence genes by PCR and whole genome sequencing of targeted genes. The data was analyzed using SPSS-23 software, for descriptive statistics to obtain …
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Extracellular matrix gene sequence variant analyses and Achilles tendinopathy
… aim of this thesis was to identify additional genetic elements predisposing individuals to risk of AT using a candidate gene, case-control genetic association approach, and to propose the biological mechanisms underlying this genetic risk. Candidate genes (COMP, THBS2, COL27A1, TNC, COL3A1, …
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Towards in vivo editing of the human microbiome
… inhabit the body and harbors a rich reservoir of genetic elements collectively called the microbiome. Efforts based on metagenomic sequencing of microbiomes associated with healthy and diseased individuals have revealed vast effects of microbiota on human health. However, compared to the expanding …
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Genomics-Based Characterization of the Microbial Community and Plasmidome of the Regina Wastewater Treatment Facility and the Surrounding Aquatic Environment
… it changes in response to seasonality (2) mobile genetic elements in untreated wastewater and activated sludge, and (3) the antimicrobial resistance (AMR) genes that are released into Wascana creek in the treated wastewater effluent. Samples of WWTP effluent, untreated wastewater, and activated …
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Specificity and benefits of an exclusion mechanism for a mobile genetic element in Bacillus subtilis
The horizontal transfer of mobile genetic elements, including Integrative and Conjugative Elements (ICEs), plays an essential role in bacterial evolution by helping to promote the spread of genes involved in antibiotic and heavy metal resistance, metabolism, symbiosis, and pathogenicity. Like …
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Integrative Metagenomic Approaches to Study Antibiotic Resistance Genes and Microbial Functions in the Preterm Infant Gut Microbiome
… and linked ARGs to bacterial hosts and mobile genetic elements. The second study focused on Staphylococcus epidermidis, Staphylococcus haemolyticus and Staphylococcus aureus, which commonly colonize the preterm gut and are major causes of neonatal infections. It examined the genomic context of …
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Conflict between bacteriophages and a mobile genetic element in bacterial immunity
… defense systems are found within mobile genetic elements, like plasmids, temperate bacteriophages, and integrative and conjugative elements (ICEs). In this thesis, I show how an ICE in the bacterium Bacillus subtilis, called ICEBs1, protects populations of cells from phage predation by …
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Autonomous replication of integrative and conjugative elements
Mobile genetic elements facilitate movement of genes, including those conferring antibiotic resistance and other traits, between bacteria. Integrative and conjugative elements (ICEs), also known as conjugative transposons, are a large family of mobile genetic elements that can transfer between …
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Dynamic regulation and functions of locus-specific DNA methylation
… and regulation of DNA methylation at various genetic elements have gathered tremendous interest over decades. The methylomes of many cell types have been described, revealing a dynamic and tissue-specific pattern of DNA methylation (tissue-specific differentially methylated regions, T-DMRs) in …
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Mobilome and antibiotic resistance in Acinetobacter baumannii
… where the Mobilome, defined as “all the mobile genetic elements in a cell”, is responsible for its genetic plasticity. The aim of this work was to analyse the role of insertion sequences (ISs), transposon-like structures, resistance-plasmids and ISCR1-like elements in the resistance to …
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Epigenetic repression of intronless mobile elements by the HUSH complex
… is under constant threat from invasion by mobile genetic elements including transposons and viruses. To defend the genome, cells recognize incoming DNA and limit its transcription through repressive chromatin modifications. The human silencing hub (HUSH) complex transcriptionally represses long …
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