In vivo steroid sensing using corona phase molecular recognition : design, synthesis, and applications

Steroid hormones dictate a number of underlying biochemical processes controlling human physiology and disease. Changes in steroid hormone concentration and activity are often either indicators or direct causes of disease. In the clinic, steroids are measured as biomarkers of health and have been studied in relation to various diseases, including various cancers, endocrine disorders, and mental illnesses. However, measurements of these important signaling molecules are commonly restricted to the analysis of blood samples using chromatography or immunoassays, which lack temporal resolution and are labor-intensive. Given the dynamic behavior of these steroids, we argue in this thesis that their diagnostic value is highly constrained because of limitations of existing measurement technology. Hence, this thesis explores and develops the engineering tools for the design, synthesis, and application of a continuous biosensor capable of measuring in vivo steroid hormones in the human body.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Chemical Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2019

Author dc:creator

• Lee, Michael A.(Michael Andrew)

Advisor dc:contributor.advisor

• Michael S. Strano.

• Chemical Engineering.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/123725

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/123725