THE HUMAN POPULATION IS AGING: HOME-BASED EXERCISE AND AMINO ACIDS SUPPLEMENTATION TO COUNTERACT THE LOSS OF MUSCLE MASS AND MUSCLE STRENGTH IN OLDER PEOPLE.

Abstract 1: The aim of this cross-sectional study was to investigate the association between lower limb strength, muscle mass and composition, and balance ability in elders. Thirthy-four older participants (Age: 65.6 ± 4.73 years; male = 10 and female = 24) were assessed for muscle strength (maximal isometric strength of knee extensors and one repetition maximum by leg press, the one repetition maximum [1RM]), balance and gait capacity (Mini-BESTest), body composition by whole-body dual energy x-ray absorptiometry (obtaining Appendicular Skeletal Muscle Mass Index, ASMMI), and magnetic resonance imaging of thigh to evaluate Intermuscular Adipose Tissue (IMAT) and muscle Cross Sectional Area (CSA). Positive correlations between 1RM and ASMMI (rs = 0.64, P < .0001) and thigh CSA (rs = 0.52, P = .0017), but not with thigh IMAT, were found. In addition, significant correlations between knee extensors strength and ASMMI (rs = 0.48, P = .004) and thigh CSA (rs = 0.49, P = .0033) and IMAT (rs = -0.35, P = .043) were observed, whereas no significant correlations between the Mini-BESTest with ASMMI, thigh CSA, and IMAT were observed. Lower limb strength positively correlated with appendicular muscle mass. Further, the maximal isometric strength of knee extensors negatively correlated with thigh IMAT in elderly patients, whereas the dynamic balance ability did not correlate with any of the morphological variables of the muscle (i.e., ASMMI, CSA, and IMAT). A reduced muscle size and strength could affect movement and reduce physical function in older patients. Improving the composition and size of muscle in elder subjects could reduce frailty and risk of falls.

Grantor dc:publisher

Università degli Studi di Milano

Year dc:date

2024

Author dc:creator

• BORGHI, STEFANO

Contributors dc:contributor

• tutor: A. La Torre ; supervisori: R. Cordella
• J. A. Vitale ; coordinatore: C. Sforza
• S. Borghi
• LA TORRE, ANTONIO
• CODELLA, ROBERTO
• SFORZA, CHIARELLA
• VITALE, JACOPO ANTONINO

• Aging
• Muscle
• Fat
• Exercise
• Amino acid
• MRI

Statement dc:rights

• info:eu-repo/semantics/openAccess
• license:Creative commons
• license uri:http://creativecommons.org/licenses/by-sa/4.0/

Language dc:language

eng

Identifier

http://dx.doi.org/10.13130/borghi-stefano_phd2024-05-28
10.13130/borghi-stefano_phd2024-05-28

OAI identifier oai:identifier

oai:air.unimi.it:2434/1045269