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National University of Ireland Maynooth
The role of the DEAD box Helicase DDX3X in Anti-‐Viral Signalling Pathways Mediated by the Kinase IKKα.
Abstract
dc:description.abstractThe human DEAD-box RNA helicase DDX3X has previously been shown to be involved in innate immune signalling in pathways mediated by IKKε and TBK1. In this work we show that DDX3X is also involved in pathways independent of these kinases, and functions by interacting with two related kinases IKKα and NIK. DDX3X enhances the activation of IKKα and subsequently, augments the activation of pathways that IKKα regulates. We show that DDX3 is involved in two important signalling pathways that are mediated by IKKα – the alternative NF-κB pathway and the TLR7 signalling pathway to type I IFN induction. We propose that DDX3X acts as a scaffolding protein that brings together IKKα and its substrates.
Degree
thesis:*- Name dc:type.qualificationname
- phd
- Level dc:type.qualificationlevel
- doctoral
- Grantor dc:publisher.institution
- National University of Ireland Maynooth
- Year dc:date.issued
- 2013
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Fullam, Anthony
Rights
- Language dc:language
- en