Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"NIK"”.
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NF-kB Inducing Kinase (NIK) Influences Eosinophil Development, Survival, and Plasticity
… gene Map3k14 encoding NF -kB inducing kinase (NIK) is knocked out, a HES-like syndrome develops that is dependent on Th2 cells and cytokines. NIK is the upstream regulator of the noncanonical NF-kB pathway and is involved in lymphoid organ development, B cell lymphopoiesis, and myelopoiesis. In …
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The non-canonical NF-kappaB pathway as a novel player in beta cell dysfunction in diabetes
… by accumulation of NF-κB-inducing kinase (NIK), IKKα phosphorylation, p100 to p52 processing and RelB accumulation. To examine the effect of NIK accumulation in β cells, we generated a genetic β cell-specific mouse model of constitutive NIK activation. The TRAF2/TRAF3/BIRC2/3 E3 ubiquitin …
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Identificação de componentes da via de sinalização mediada pela proteína NIK, um receptor que interage com a proteína NSP de geminivírus
… a alguns membros desta família. Os receptores NIK1, NIK2 e NIK3 de Arabidopsis thaliana pertecem à sub-familia LRRII-RLK e foram inicialmente identificados pela sua capacidade de interagir com a proteína NSP de geminivírus. Em resposta a um estímulo desconhecido, NSP-interacting kinases (NIKs) …
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Dysregulation of Noncanonical NF-κB Signaling in Gastrointestinal Diseases
… NF-κB pathway is unique as it requires NIK, the NF-κB-inducing Kinase, to further elicit signal transduction of this pathway. Noncanonical NF-κB activation is critical to maintaining gut health, as signaling is regulated at a precise level to ensure a balance of pro-/anti-inflammatory …
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Noncanonical NF-KB in Gastrointestinal Disease
… revealed that loss of NF-KB-inducing kinase (NIK), the bottleneck molecule in noncanonical NF-KB signaling, results in targeted esophageal inflammation, remodeling, and gene expression changes that are comparable to the human disease. In Chapter 4, we examine the role of noncanonical NF-KB in …
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Host cell signaling in response to RSV infection
… that RIG-I was involved in the activation of NIK/IKK alpha complex, two key noncanonical kinases that induce the protelytic processing of an I kappa B alpha-like inhibitor p100 to p52. I also proved that a fraction of RelA was associated with cytoplasmic p100. In addition, the RSV-induced …
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Crystallographic studies of the metal-responsive transcription factor NikR
… repression of the nickel permease complex, NikABCDE, mediated by the NikR metalloregulatory transcription factor. To understand how this takes place at a molecular level, X-ray crystallography was used to determine three- dimensional structures of the NikR. Structures of apo-NikR and …
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Mechanism of Chimeric Vaccine Mediated Immune Suppression of Human Dendritic Cells
… Further, blocking the NF-κB-inducing kinase (NIK) phosphorylation of IKK-α dimers and translocation of p52/RelB complexes to the nucleus with anti-NIK siRNA, significantly inhibited IDO1 expression in human DCs. Chromatin immunoprecipitation (ChIP) analysis, showed that RelB-p52 dimers bound …
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The role of the DEAD box Helicase DDX3X in Anti-‐Viral Signalling Pathways Mediated by the Kinase IKKα.
… by interacting with two related kinases IKKα and NIK. DDX3X enhances the activation of IKKα and subsequently, augments the activation of pathways that IKKα regulates. We show that DDX3 is involved in two important signalling pathways that are mediated by IKKα – the alternative NF-κB pathway and …
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Negative Regulation of Inflammation: Implications for Inflammatory Bowel Disease and Colitis Associated Cancer
… role of a protein, termed NF-κB inducing kinase (NIK), in intestinal epithelial cell growth and proliferation. Ultimately, ex vivo organoid culture can serve as an important model system to study the contribution of NIK in intestinal stem cell renewal, cancer progression, as well as in maintenance …
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The tomato RLK superfamily: phylogeny and functional predictions about the role of the LRRII- RLK subfamily in antiviral defense
… no fato de que membros de RLKs de Arabidopsis (NIK1, NIK2, NIK3 e NsAK) interagem com o NSP de begomovirus, foi verificado se ortólogos de NIKs, BAK1 e NsAK interagem com o NSP de Tomato Yellow Spot Virus (ToYSV). Os ortólogos dos genes que interagem com o NSP em tomate, SlNIKs e SlNsAK, …
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Novel interactions and functions of the Adenomatous polyposis coli protein
… I further focused my studies on Misshapen/NIK-related kinase 1 (MINK1) which I identified and validated as a novel interactor of APC. I could show that APC depletion leads to an increase in MINK1 protein levels, that this effect is b-catenin-independent and furthermore mediated …
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Metodi sperimentali per la caratterizzazione di schiume sintattiche e leghe metalliche ad elevato strain rate
… di un anno svolto sotto la supervisione del Dr. Nik Petrinic e del Dr. Vito Tagarielli ed è frutto della stretta attività di collaborazione tra il laboratorio suddetto ed una nota multinazionale operante nel settore aerospaziale. All¿interno del lavoro di tesi vengono descritte accuratamente le …
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Interrogating novel functions of the I kappa B kinases via CRISPR-Cas9 gene editing and small molecule inhibition
… of TNF-family cytokines, which requires IKKα and NIK kinase. We have generated and validated CRISPR-Cas9 IKKα, IKKβ and IKKα/β DKO HCT116 colorectal cancer cell lines to interrogate novel functions of the I kappa B kinases in colorectal cancer, including the relative contributions of these kinases …
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Kualiti kepimpinan dalam kalangan penyelaras homestay: perspektif pengusaha homestay
Homestay atau lebih dikenali dengan nama inap desa adalah merupakan satu produk pelancongan yang semakin mendapat tempat di Malaysia. Program homestay begitu dikenali dan ia merujuk kepada penginapan pelancong tinggal bersama keluarga angkat, menjamu selera dan terlibat dalam aktiviti tradisional …
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The HRM role of line managers: A Malaysian case study
While HRM has long been part of the line manager’s role, it has now become a crucial component. Unfortunately, for many line managers, their HRM role is uncertain, in terms of their coverage and depth of involvement in HRM activities. It is therefore difficult to measure whether their involvement …
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Stress intensity factors of edge cracks in dissimilar joint plates
Nowadays, there are many applications in which need the combination or different materials. The development of this is caused by the mechanical wear problem, a high temperature situation or other conditions in which different properties are required from different parts of the same applications. …
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Smartphone-based robot control for localisation
This project developed to use smartphone as a robot controller since it’s more powerful and equipped with several sensors that are useful for robots. The project uses Android application as well as Arduino microcontroller to locate and control the robot via DTMF tone from distance. Magnetometer and …
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Determinants of sales performance in insurance industry:a cross-cultural comparison between the UK and Malaysia
This thesis is concerned with an empirical investigation of the factors that predict a successful salesperson, using a cross-cultural comparison of two countries: the UK and Malaysia. Besides collecting quantitative data, qualitative data on organisational, environmental and cultural factors were …
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Studies on the mechanism of insulin signaling reduction in high glucose/palmitate-induced INS-1 beta cell death
… IκBβ, NFκB 억제가 세포사에 미 치는 영향 35 2. IKK upstream 인 NIK, TLR2, TLR4, Myd88 억제가 세포사에 미치는 영향 40 Ⅳ. 고찰 47 A. HG/PA에 의한 INS-1 베타세포의 세포사 증가 47 B. HG/PA에 의한 INS-1 세포사는 IRS-1 tyrosine 인산화의 감소가 원인 48 C. 스트레스와 inflammation신호에서의 INS-1 베타세포 사멸 작용기전 확인 48 D. HG/PA에 의한 세포 사멸과 inflammation 신호와의 …
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