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National University of Ireland Maynooth
Synthesis, Characterisation and Antifungal Activity of Copper(II)-Functionalised Silicone Polymers and Silicone-Coated Magnetic Nanoparticles
Abstract
dc:description.abstractTwo families of amine-functionalised silicone polymers were prepared using monomeric (3-aminopropyl)triethoxysilane (APTES) and (3-trimethoxysilylpropyl)diethylene triamine (TMSPDT). Schiff base derivatives of these polymers were synthesised using salicylaldehyde. The same suite of polymers were also formed as a surface coating on magnetite nanoparticles (Fe3O4-MNPs). Copper(II) ions were coordinated to the pendant amine groups of all of the polymers. In vitro tests using the fungal pathogen, Candida albicans, revealed that the silicone polymers, their Cu(II) complexes and the Schiff base salicylate derivatives inhibited cell growth. None of the silicone-coated Fe3O4-MNPs were bioactive.
Degree
thesis:*- Level dc:type.qualificationlevel
- masters
- Grantor dc:publisher.institution
- National University of Ireland Maynooth
- Year dc:date.issued
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Reynolds, Collette Regina
Rights
- Language dc:language
- en