{"id":{"repo_id":"maynooth","oai_identifier":"oai:mural.maynoothuniversity.ie:7531"},"canonical_url":"https://search.dev.ndltd.org/etd/maynooth/oai:mural.maynoothuniversity.ie:7531","repository":{"repo_id":"maynooth","name":"National University of Ireland - Maynooth","base_url":"http://mural.maynoothuniversity.ie/cgi/oai2"},"display":{"title":"Synthesis, Characterisation and Antifungal Activity of Copper(II)-Functionalised Silicone Polymers and Silicone-Coated Magnetic Nanoparticles","abstract":"Two families of amine-functionalised silicone polymers were prepared using monomeric (3-aminopropyl)triethoxysilane (APTES) and (3-trimethoxysilylpropyl)diethylene triamine (TMSPDT). Schiff base derivatives of these polymers were synthesised using salicylaldehyde. The same suite of polymers were also formed as a surface coating on magnetite nanoparticles (Fe3O4-MNPs). Copper(II) ions were coordinated to the pendant amine groups of all of the polymers. In vitro tests using the fungal pathogen, Candida albicans, revealed that the silicone polymers, their Cu(II) complexes and the Schiff base salicylate derivatives inhibited cell growth. None of the silicone-coated Fe3O4-MNPs were bioactive.","abstract_html":"Two families of amine-functionalised silicone polymers were prepared using monomeric (3-aminopropyl)triethoxysilane (APTES) and (3-trimethoxysilylpropyl)diethylene triamine (TMSPDT). Schiff base derivatives of these polymers were synthesised using salicylaldehyde. The same suite of polymers were also formed as a surface coating on magnetite nanoparticles (Fe3O4-MNPs). Copper(II) ions were coordinated to the pendant amine groups of all of the polymers. In vitro tests using the fungal pathogen, Candida albicans, revealed that the silicone polymers, their Cu(II) complexes and the Schiff base salicylate derivatives inhibited cell growth. None of the silicone-coated Fe3O4-MNPs were bioactive.","abstract_has_math":false,"creators":["Reynolds, Collette Regina"],"institution":"National University of Ireland Maynooth","degree_name":null,"degree_level":"masters","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015","date_published":"2015","updated_at":"2026-07-24T03:02:54Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Reynolds, Collette Regina"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015"]},{"key":"dc:date.issued","label":"Date","values":["2015"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["National University of Ireland Maynooth"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://mural.maynoothuniversity.ie/id/eprint/7531/"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["masters"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://mural.maynoothuniversity.ie/id/eprint/7531/1/C%20Reynolds%20THESIS.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Two families of amine-functionalised silicone polymers were prepared using monomeric (3-aminopropyl)triethoxysilane (APTES) and (3-trimethoxysilylpropyl)diethylene triamine (TMSPDT). Schiff base derivatives of these polymers were synthesised using salicylaldehyde. The same suite of polymers were also formed as a surface coating on magnetite nanoparticles (Fe3O4-MNPs). Copper(II) ions were coordinated to the pendant amine groups of all of the polymers. In vitro tests using the fungal pathogen, Candida albicans, revealed that the silicone polymers, their Cu(II) complexes and the Schiff base salicylate derivatives inhibited cell growth. None of the silicone-coated Fe3O4-MNPs were bioactive."]},{"key":"dc:format","label":"Dc Format","values":["text"]},{"key":"dc:title","label":"Title","values":["Synthesis, Characterisation and Antifungal Activity of Copper(II)-Functionalised Silicone Polymers and Silicone-Coated Magnetic Nanoparticles"]}]}],"canonical_facts":{"dc:creator":["Reynolds, Collette Regina"],"dc:date":["2015"],"dc:date.issued":["2015"],"dc:description.abstract":["Two families of amine-functionalised silicone polymers were prepared using monomeric (3-aminopropyl)triethoxysilane (APTES) and (3-trimethoxysilylpropyl)diethylene triamine (TMSPDT). Schiff base derivatives of these polymers were synthesised using salicylaldehyde. The same suite of polymers were also formed as a surface coating on magnetite nanoparticles (Fe3O4-MNPs). Copper(II) ions were coordinated to the pendant amine groups of all of the polymers. In vitro tests using the fungal pathogen, Candida albicans, revealed that the silicone polymers, their Cu(II) complexes and the Schiff base salicylate derivatives inhibited cell growth. None of the silicone-coated Fe3O4-MNPs were bioactive."],"dc:format":["text"],"dc:identifier.uri":["https://mural.maynoothuniversity.ie/id/eprint/7531/1/C%20Reynolds%20THESIS.pdf"],"dc:language":["en"],"dc:publisher.institution":["National University of Ireland Maynooth"],"dc:relation.isreferencedby":["https://mural.maynoothuniversity.ie/id/eprint/7531/"],"dc:title":["Synthesis, Characterisation and Antifungal Activity of Copper(II)-Functionalised Silicone Polymers and Silicone-Coated Magnetic Nanoparticles"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["masters"]},"updated_at":"2026-07-24T03:02:54Z"}