The Effects of Physical Activity and Nutrient Intake on the Risk of Hip Fracture : Results From The Adventist Health Study-2

<p>This is a two year of follow up study of Adventist Health Study-2 (AHS-2). We assessed the association between physical activity, nutrient intake and risk of hip fracture among peri- and post menopausal Caucasian women using unconditional logistic regression models. All subjects completed a lifestyle questionnaire which including information of physical activity and frequency and portion size of food intake at enrollment into the study (2002-2007). The “Bi-Annual Hospitalization History” questionnaire which included a question about hip fractures due to minor trauma/falls was sent to subjects approximately two years after enrollment, with a response rat of 82.84%. In this cohort, a total of 151 new cases of hip fracture occurred among 25,398 peri- and post- menopausal women aged 45 or older during the 55, 313 person years of follow-up period giving an incidence rate of 273 per 100,000 person-years and 282 per 100,000 person years after direct age-adjustment (using the US 2000 female white population). There was a dose response inverse relationship between level of regular walking, running and jogging and hip fracture with 64% reduction of risk for those who reported walking more than 5 miles per week compared to those with less than 2.5 miles per week or no regular exercise. The risk of hip fracture was inversely associated with dairy food intake [OR = 0.86 (95% Cl: 0.39, 1.90) and OR = 0.70 (95% Cl: 0.35, 1.41), respectively, for intake of 2-/wk and 7+times/wk vs./wk]. Similarly, those in the highest tertile of dairy source protein (10.47+ g/day), experienced a clear lowering in hip fracture risk compared to those in the lowest tertile (< 4.31 g/day) of dairy source protein (OR=0.39 (95% Cl: 0.16, 0.98). Dairy protein showed an independent protective effect on hip fracture after adjusting for total protein and dietary calcium. In summary, our findings suggest that a regular walking program of at least 5 miles per week and dairy protein consumption lower the risk the hip fracture in this study population.</p>

Name thesis:degree_name

Doctor of Public Health (DrPH)

Level thesis:degree_level

Thesis

Year

2009

Author dc:creator

• Liao, Wen-Ling

Contributors dc:contributor

• Synnove Knutsen
• W. Lawrence Beeson
• Donna Gregory Thorpe

• Clinical Trials
• Epidemiology
• Human and Clinical Nutrition
• Hip Fractures -- diagnosis; Hip Fractures -- epidemiology; Osteoporosis, Postmenopausal -- physiopathology; Bone Density; Body Mass Index; Nutritional Support; Dietary Proteins -- administration & dosage; Health Behavior; Physical Fitness; Vegetarianism -- Religious aspects -- Seventh-day Adventists; Nutrition -- Religious aspects -- Seventh-day Adventists; Caucasian Race; Prospective Studies.

Statement dc:rights

• This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Language dc:language

English

Repository record dc:identifier

https://scholarsrepository.llu.edu/etd/900

OAI identifier oai:identifier

oai:scholarsrepository.llu.edu:etd-2028