Acclimatization to High-Altitude, Long-Term Hypoxia Alters BK Channel Structure and Function

<p>We examined the major possible mechanisms for the left shift of the BK channel I-V relationship in native basilar artery myocytes from the two LTH groups. These mechanisms included: differential expression of the accessary BK -1 subunit; differential phosphorylation of the BK subunit; and splice variation of the BK subunit. Using molecular cloning, heterologous expression, and patch-clamp electrophysiology techniques, we elucidated a mechanism that, at least in part, contributes to the differences we observed between channels from native normoxic and LTH myocytes.</p>

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Basic Sciences

Year

2015

Author dc:creator

• Tao, Xiaoxiao

Contributors dc:contributor

• Hessinger, David A.
• Buchholz, John N.
• Longo, Lawrence D.
• Mohan, Subburaman
• Watts, Kylie J.
• Zhang, Lubo

• Chemical and Pharmacologic Phenomena
• Medical Pharmacology
• Medicine and Health Sciences
• Anoxia; Hypoxia-Ischemia - Brain; Acclimatization; Altitude Sickness; Adaptation - Physiological; Myocytes; Potassium Channels - Calcium-Activated; Large-Conductance Calcium-activated Potassium Channels; Calcium Channel Blockers; Ion Channel Gating;
• Left Shift of the BK Channel; Basilar Artery Myocytes; Molecular Cloning; Heterologous Express; Patch-Clamp Electrophysiology;

Statement dc:rights

• This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Language dc:language

English

Repository record dc:identifier

https://scholarsrepository.llu.edu/etd/269

OAI identifier oai:identifier

oai:scholarsrepository.llu.edu:etd-1274