Das multifokale Musterelektroretinogramm bei Patienten mit Glaukom und Neuritis Nervi Optici

Background: The multifocal pattern electroretinogram (mfPERG) allows analysis of local ganglion cell dysfunction by multifocal stimulation. Aim of this study was to investigate if this method is an useful tool for diagnosing and following glaucoma patients. Methods: Measurements on 52 age-matched normal eyes were compared to those on 23 eyes with different stages of glaucoma. A RETIScan system was used to generate a stimulus pattern of 19 hexagons, each consisting of 6 triangles. The triangles pattern-reversed black to white at 75 Hz. Those 19 hexagons form 3 stimulus regions: a central field, a middle and a peripheral ring. The complete array subtended 48° at the eye. The hexagons alternated black-white following a corrected binary m-sequence (length 512, 10 cycles with 39 second each). Corneal loop electrodes were used with reference electrode on temple. Results: The mfPERGs were analyzed for significant changes in amplitude and latency of the positive and negative responses. For patients with glaucoma the positive P-50 and negative N-95 components were significantly reduced for the central area and both rings compared to normal volunteers (p<0.001, Mann-Whitney-U). The most distinct reduction was observed for N-95 and the central ring. Changes in latencies were not conclusive. The reduction of the components increased with the stage of glaucoma. A predictive model for detecting early glaucomatous changes was designed based on P-50-N-95 with 88% sensitivity and 77% specificity. Conclusion: The highly significant reduction of components in glaucoma makes the mfPERG an useful tool for diagnosing and following glaucoma.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Ludwig-Maximilians-Universität

Year

2002

Author dc:creator

• Stiefelmeyer, Sandra

Repository record source_url

https://edoc.ub.uni-muenchen.de/215/

OAI identifier oai:identifier

oai:edoc.ub.uni-muenchen.de:215