Engineering of poly(2-oxazoline)s for a potential use in biomedical applications

This PhD work is based on the design of poly(2-oxazoline) (POx) hydrogels and nanogels, by chemical or physical cross-linking, aimed to be used for biomedical applications. Nanogels were first prepared in dilute media and in inverse emulsion based on a statistical copolymer made of 2-ethyl-2-oxazoline and ethylene imine units. These stimuli-responsive nanogels were swelling in acidic media and were cleaved in reductive environment. They proved to be non-cytotoxic and act as protein repellent. Second, a reactive platform based on a statistical POx polymer bearing aldehyde functionalities was engineered, enabling the synthesis of graft and cross-linked POx. Last, a block copolymer made of 2-methyl- and 2-isopropyl-2- oxazoline units, proved to self-assemble into micelles when heated above its LCST, for a short period of time (< 1h30). When annealed for a longer time (> 1h30), crystallization-driven self-assembly led to the formation of different morphologies (fiber rods and cross-linked micelles).

Grantor dc:publisher

ULiège - Université de Liège

Year dc:date

2014

Author dc:creator

• Legros, Camille

• polyoxazolines
• nanogel
• hydrogel
• responsiveness
• crystallization
• LCST
• aldehyde
• protein repellent
• cytotoxicity
• Physical, chemical, mathematical & earth Sciences
• Chemistry
• Physique, chimie, mathématiques & sciences de la terre
• Chimie

Statement dc:rights

• open access
• info:eu-repo/semantics/openAccess

Licence

• http://purl.org/coar/access_right/c_abf2

Language dc:language

en

Identifier

info:hdl:2268/175218

OAI identifier oai:identifier

oai:orbi.ulg.ac.be:2268/175218