{"id":{"repo_id":"liege","oai_identifier":"oai:orbi.ulg.ac.be:2268/175218"},"canonical_url":"https://search.dev.ndltd.org/etd/liege/oai:orbi.ulg.ac.be:2268/175218","repository":{"repo_id":"liege","name":"Université de Liège","base_url":"https://orbi.uliege.be/oai/request"},"display":{"title":"Engineering of poly(2-oxazoline)s for a potential use in biomedical applications","abstract":"This PhD work is based on the design of poly(2-oxazoline) (POx) hydrogels and nanogels, by chemical or physical cross-linking, aimed to be used for biomedical applications. Nanogels were first prepared in dilute media and in inverse emulsion based on a statistical copolymer made of 2-ethyl-2-oxazoline and ethylene imine units. These stimuli-responsive nanogels were swelling in acidic media and were cleaved in reductive environment. They proved to be non-cytotoxic and act as protein repellent. Second, a reactive platform based on a statistical POx polymer bearing aldehyde functionalities was engineered, enabling the synthesis of graft and cross-linked POx. Last, a block copolymer made of 2-methyl- and 2-isopropyl-2- oxazoline units, proved to self-assemble into micelles when heated above its LCST, for a short period of time (< 1h30). When annealed for a longer time (> 1h30), crystallization-driven self-assembly led to the formation of different morphologies (fiber rods and cross-linked micelles).","abstract_html":"This PhD work is based on the design of poly(2-oxazoline) (POx) hydrogels and nanogels, by chemical or physical cross-linking, aimed to be used for biomedical applications. Nanogels were first prepared in dilute media and in inverse emulsion based on a statistical copolymer made of 2-ethyl-2-oxazoline and ethylene imine units. These stimuli-responsive nanogels were swelling in acidic media and were cleaved in reductive environment. They proved to be non-cytotoxic and act as protein repellent. Second, a reactive platform based on a statistical POx polymer bearing aldehyde functionalities was engineered, enabling the synthesis of graft and cross-linked POx. Last, a block copolymer made of 2-methyl- and 2-isopropyl-2- oxazoline units, proved to self-assemble into micelles when heated above its LCST, for a short period of time (&lt; 1h30). When annealed for a longer time (&gt; 1h30), crystallization-driven self-assembly led to the formation of different morphologies (fiber rods and cross-linked micelles).","abstract_has_math":false,"creators":["Legros, Camille"],"institution":"ULiège - Université de Liège","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-10-31","date_published":"2014-10-31","updated_at":"2026-07-24T02:49:27Z","subjects":["polyoxazolines","nanogel","hydrogel","responsiveness","crystallization","LCST","aldehyde","protein repellent","cytotoxicity","Physical, chemical, mathematical & earth Sciences","Chemistry","Physique, chimie, mathématiques & sciences de la terre","Chimie"],"languages":["en"],"rights":["open access","info:eu-repo/semantics/openAccess"],"rights_urls":["http://purl.org/coar/access_right/c_abf2"],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["info:hdl:2268/175218"],"render_values":[{"text":"info:hdl:2268/175218","href":null,"code":true}]}]},"links":{"outbound_url":"https://orbi.uliege.be/handle/2268/175218","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Legros, Camille"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-10-31"]},{"key":"dc:publisher","label":"Institution","values":["ULiège - Université de Liège"]},{"key":"dc:type","label":"Dc Type","values":["doctoral thesis","http://purl.org/coar/resource_type/c_db06","info:eu-repo/semantics/doctoralThesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["polyoxazolines","nanogel","hydrogel","responsiveness","crystallization","LCST","aldehyde","protein repellent","cytotoxicity","Physical, chemical, mathematical & earth Sciences","Chemistry","Physique, chimie, mathématiques & sciences de la terre","Chimie"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["open access","http://purl.org/coar/access_right/c_abf2","info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://orbi.uliege.be/handle/2268/175218","info:hdl:2268/175218","https://orbi.uliege.be/bitstream/2268/175218/1/THESE%20-%20VF.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["This PhD work is based on the design of poly(2-oxazoline) (POx) hydrogels and nanogels, by chemical or physical cross-linking, aimed to be used for biomedical applications. Nanogels were first prepared in dilute media and in inverse emulsion based on a statistical copolymer made of 2-ethyl-2-oxazoline and ethylene imine units. These stimuli-responsive nanogels were swelling in acidic media and were cleaved in reductive environment. They proved to be non-cytotoxic and act as protein repellent. Second, a reactive platform based on a statistical POx polymer bearing aldehyde functionalities was engineered, enabling the synthesis of graft and cross-linked POx. Last, a block copolymer made of 2-methyl- and 2-isopropyl-2- oxazoline units, proved to self-assemble into micelles when heated above its LCST, for a short period of time (< 1h30). When annealed for a longer time (> 1h30), crystallization-driven self-assembly led to the formation of different morphologies (fiber rods and cross-linked micelles)."]},{"key":"dc:format","label":"Dc Format","values":["235"]},{"key":"dc:title","label":"Title","values":["Engineering of poly(2-oxazoline)s for a potential use in biomedical applications"]}]}],"canonical_facts":{"dc:creator":["Legros, Camille"],"dc:date":["2014-10-31"],"dc:description":["This PhD work is based on the design of poly(2-oxazoline) (POx) hydrogels and nanogels, by chemical or physical cross-linking, aimed to be used for biomedical applications. Nanogels were first prepared in dilute media and in inverse emulsion based on a statistical copolymer made of 2-ethyl-2-oxazoline and ethylene imine units. These stimuli-responsive nanogels were swelling in acidic media and were cleaved in reductive environment. They proved to be non-cytotoxic and act as protein repellent. Second, a reactive platform based on a statistical POx polymer bearing aldehyde functionalities was engineered, enabling the synthesis of graft and cross-linked POx. Last, a block copolymer made of 2-methyl- and 2-isopropyl-2- oxazoline units, proved to self-assemble into micelles when heated above its LCST, for a short period of time (< 1h30). When annealed for a longer time (> 1h30), crystallization-driven self-assembly led to the formation of different morphologies (fiber rods and cross-linked micelles)."],"dc:format":["235"],"dc:identifier":["https://orbi.uliege.be/handle/2268/175218","info:hdl:2268/175218","https://orbi.uliege.be/bitstream/2268/175218/1/THESE%20-%20VF.pdf"],"dc:language":["en"],"dc:publisher":["ULiège - Université de Liège"],"dc:rights":["open access","http://purl.org/coar/access_right/c_abf2","info:eu-repo/semantics/openAccess"],"dc:subject":["polyoxazolines","nanogel","hydrogel","responsiveness","crystallization","LCST","aldehyde","protein repellent","cytotoxicity","Physical, chemical, mathematical & earth Sciences","Chemistry","Physique, chimie, mathématiques & sciences de la terre","Chimie"],"dc:title":["Engineering of poly(2-oxazoline)s for a potential use in biomedical applications"],"dc:type":["doctoral thesis","http://purl.org/coar/resource_type/c_db06","info:eu-repo/semantics/doctoralThesis"]},"updated_at":"2026-07-24T02:49:27Z"}