Plasticity cascades and place cell activity differ in new spatial learning based on context familiarity

In these experiments I have studied the effects of context familiarity on new spatial learning on a protein, behavioural, and cellular scale. I found evidence that there is greater expression of plasticity products in MEC-connected regions of the HPC in novel context learning and LEC-connected regions of the HPC in familiar context learning. Also in this experiment I observed a greater effect in downstream proteins, supporting the convergence of these cascades. In the second set of experiments I introduced the dry-land contextual navigation task and demonstrated learning in it. Furthermore, I compared the results in this task with rats in a water-based task and found that win-stay tendencies differ between the two tasks. Finally, in the last experiment I assessed place-cell activity in dorsal CA1 in freely-behaving mice in the DCNT. I found evidence of global remapping but not encoding of the reward.

Authors

• Fraser, Ellen
• University of Lethbridge. Faculty of Arts and Science

• Brain plasticity and reorganization
• Cognition
• Developmental neurobiology
• Long-term Potentiation
• Neural circuitry -- Adaptation
• Neuroplasticity

Identifier

hdl:10133/5753

OAI identifier oai:identifier

oai:opus.uleth.ca:10133/5753