{"id":{"repo_id":"lethbridge","oai_identifier":"oai:opus.uleth.ca:10133/5753"},"canonical_url":"https://search.dev.ndltd.org/etd/lethbridge/oai:opus.uleth.ca:10133/5753","repository":{"repo_id":"lethbridge","name":"University of Lethbridge","base_url":"https://opus.uleth.ca/server/oai/request"},"display":{"title":"Plasticity cascades and place cell activity differ in new spatial learning based on context familiarity","abstract":"In these experiments I have studied the effects of context familiarity on new spatial learning on a protein, behavioural, and cellular scale. I found evidence that there is greater expression of plasticity products in MEC-connected regions of the HPC in novel context learning and LEC-connected regions of the HPC in familiar context learning. Also in this experiment I observed a greater effect in downstream proteins, supporting the convergence of these cascades. In the second set of experiments I introduced the dry-land contextual navigation task and demonstrated learning in it. Furthermore, I compared the results in this task with rats in a water-based task and found that win-stay tendencies differ between the two tasks. Finally, in the last experiment I assessed place-cell activity in dorsal CA1 in freely-behaving mice in the DCNT. I found evidence of global remapping but not encoding of the reward.","abstract_html":"In these experiments I have studied the effects of context familiarity on new spatial learning on a protein, behavioural, and cellular scale. I found evidence that there is greater expression of plasticity products in MEC-connected regions of the HPC in novel context learning and LEC-connected regions of the HPC in familiar context learning. Also in this experiment I observed a greater effect in downstream proteins, supporting the convergence of these cascades. In the second set of experiments I introduced the dry-land contextual navigation task and demonstrated learning in it. Furthermore, I compared the results in this task with rats in a water-based task and found that win-stay tendencies differ between the two tasks. Finally, in the last experiment I assessed place-cell activity in dorsal CA1 in freely-behaving mice in the DCNT. I found evidence of global remapping but not encoding of the reward.","abstract_has_math":false,"creators":["Fraser, Ellen","University of Lethbridge. Faculty of Arts and Science"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2020,"date_issued":"2020","date_published":"2020","updated_at":"2026-07-27T20:02:26Z","subjects":["Brain plasticity and reorganization","Cognition","Developmental neurobiology","Long-term Potentiation","Neural circuitry -- Adaptation","Neuroplasticity"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10133/5753"],"render_values":[{"text":"hdl:10133/5753","href":null,"code":true}]}]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2020"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Brain plasticity and reorganization","Cognition","Developmental neurobiology","Long-term Potentiation","Neural circuitry -- Adaptation","Neuroplasticity"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:10133/5753"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.other","label":"Dc Description Other","values":["In these experiments I have studied the effects of context familiarity on new spatial learning on a protein, behavioural, and cellular scale. I found evidence that there is greater expression of plasticity products in MEC-connected regions of the HPC in novel context learning and LEC-connected regions of the HPC in familiar context learning. Also in this experiment I observed a greater effect in downstream proteins, supporting the convergence of these cascades. In the second set of experiments I introduced the dry-land contextual navigation task and demonstrated learning in it. Furthermore, I compared the results in this task with rats in a water-based task and found that win-stay tendencies differ between the two tasks. Finally, in the last experiment I assessed place-cell activity in dorsal CA1 in freely-behaving mice in the DCNT. I found evidence of global remapping but not encoding of the reward."]},{"key":"dc:title","label":"Title","values":["Plasticity cascades and place cell activity differ in new spatial learning based on context familiarity"]}]}],"canonical_facts":{"dc:date.issued":["2020"],"dc:description.other":["In these experiments I have studied the effects of context familiarity on new spatial learning on a protein, behavioural, and cellular scale. I found evidence that there is greater expression of plasticity products in MEC-connected regions of the HPC in novel context learning and LEC-connected regions of the HPC in familiar context learning. Also in this experiment I observed a greater effect in downstream proteins, supporting the convergence of these cascades. In the second set of experiments I introduced the dry-land contextual navigation task and demonstrated learning in it. Furthermore, I compared the results in this task with rats in a water-based task and found that win-stay tendencies differ between the two tasks. Finally, in the last experiment I assessed place-cell activity in dorsal CA1 in freely-behaving mice in the DCNT. I found evidence of global remapping but not encoding of the reward."],"dc:identifier":["hdl:10133/5753"],"dc:subject":["Brain plasticity and reorganization","Cognition","Developmental neurobiology","Long-term Potentiation","Neural circuitry -- Adaptation","Neuroplasticity"],"dc:title":["Plasticity cascades and place cell activity differ in new spatial learning based on context familiarity"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T20:02:26Z"}