Taxotere suppresses breast cancer growth through inducing lincRNA-p21 expression

It has been reported that long non-coding RNA lincRNA-p21 is induced upon radiation and chemotherapy. This induction contributes to DNA-damage repair, cell death and cell cycle regulation. In this study, we focused on Taxotere (TXT) mediated chemotherapy of breast cancer cells and found that lincRNA-p21 is robotically induced upon TXT treatment. Secondly, we observed increased chemoresistance in three different breast cancer cell lines with lincRNA-p21 knockdown. Mechanistically, we found that lincRNA-p21 knockdown lead to decreased cell death during chemotherapy comparing to the negative control. In addition, our work showed that p21 is a downstream target of lincRNA-p21 in human breast cancer cells, and the loss of lincRNA-p21 caused p21 downregulation at both the RNA and protein levels.

Grantor dc:publisher

University of Kansas

Year dc:date.issued

2017

Author dc:creator

• Guo, Yuxiao

Advisor dc:contributor.advisor

• Xu, Liang

• Biology
• Breast Cancer
• Long non-coding RNA
• Taxotere

Statement dc:rights

• This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.

Language dc:language.iso

en

Dc Identifier Other

https://www.proquest.com/LegacyDocView/DISSNUM/10256469

OAI identifier oai:identifier

oai:kuscholarworks.ku.edu:1808/37320