Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Taxotere"”.
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Taxotere suppresses breast cancer growth through inducing lincRNA-p21 expression
… cycle regulation. In this study, we focused on Taxotere (TXT) mediated chemotherapy of breast cancer cells and found that lincRNA-p21 is robotically induced upon TXT treatment. Secondly, we observed increased chemoresistance in three different breast cancer cell lines with lincRNA-p21 knockdown. …
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Synthesis of Taxol™ Analogs as Conformational Probes
… in the late 1960s, and the semisynthetic analog Taxotere™ have proven clinical importance for the treatment of ovarian and breast cancer. Taxol™ exerts its biological effect by binding to polymerized tubulin and stabilizing the resulting microtubules. Studies aimed at understanding the …
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The chemistry of cephalomannine
… be significantly more active than Taxol. Third, Taxotere, 10- acetyltaxotere, N-debenzoyl-N-(phenoxyacetyl)taxol, and the cephalomannine diol were synthetically prepared for testing in several tubulin polymerization systems. Earlier studies had shown that some Taxol analogs had the ability to …
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Molecular mechanisms of drug resistance, invasion and metastasis in pancreatic carcinoma
… of three cell lines with epirubicin, taxotere and gemcitabine. The drug-selected cell lines, in general, displayed low changes in sensitivity to their respective selecting drugs and no obvious cross-resistance profile. However, drug treatment modulated the invasive potential of the …
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The molecular effects of low dose fractionated radiation treatment on Ovarian Adenocarcinoma
… in combination with the chemotherapeutic agent Taxotere was effective in both radiosensitive (BO-!) and radioresistant (SW626) cell lines. This low dose fractionated treatment (LDFRT) was effective in reducing cellular surviving fractions of these cell lines irrespective of the cellularp53 …
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Development and Intratumoral Distribution of Block Copolymer Micelles as Nanomedicines for the Targeted Delivery of Chemotherapy to Solid Tumors
… in monolayer and spheroid cultures relative to Taxotere®. Cells cultured as spheroids were less responsive to treatment relative to monolayer cultures due to mechanisms of drug resistance associated with structural and microenvironmental properties of the 3-D tissue. Computational, image-based …
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The Potential Role of LEDGF/p75 in Prostate Cancer
… the pro-oxidants t-butyl hydroperoxide (TBHP) or Taxotere® but not to cell death induced by classical apoptotic stimuli such as staurosporine and TRAIL. RWPE-2 cells overexpressing LEDGF/p75 showed decreased levels of reactive oxygen species and the upregulation of the endoplasmic reticulum …
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Efficient Drug and Nucleic Acid Delivery Systems based on Synthetic Amphiphiles with Tuned Oil/Water Interfaces
… micelles and also to the clinically used Taxotere® formulation towards cancer cell killing and tumor treatment, without displaying any significant toxicity in experimental animals. The second part of the dissertation focuses on the development and assessment of a pyridinium-based …