Hydrogen sulfide therapy improves intestinal recovery through endothelial nitric oxide dependent mechanisms

H2S is a gaseous mediator that acts as an anti-inflammatory agent contributing to gastrointestinal mucosal defense. It promotes vascular dilation, mucosal repair, and resolution of inflammation following intestinal ischemia and may be exploited as a novel therapeutic agent. It is unclear if H2S works through nitric oxide-dependent pathways in the intestine. We appreciated that H2S was able to improve post-ischemic recovery of mesenteric perfusion, mucosal integrity, and inflammation. The beneficial effects of H2S appear to be mediated through endothelial nitric oxide-dependent pathways.

Author dc:creator

• Jensen, Amanda

Advisor dc:contributor.advisor

• Markel, Troy

• H2S
• eNOS
• Intestinal ischemia

Statement dc:rights

• Attribution-NonCommercial-NoDerivs 3.0 United States

Licence dc:rights.uri

• http://creativecommons.org/licenses/by-nc-nd/3.0/us/

Language dc:language.iso

en_US

DOI

10.7912/C2PH2K

Identifier URI

http://dx.doi.org/10.7912/C2/2774

OAI record oai:identifier

https://scholarworks.indianapolis.iu.edu/server/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Ascholarworks.indianapolis.iu.edu%3A1805%2F17057