Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Resolution of Inflammation"”.
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Hydrogen sulfide therapy improves intestinal recovery through endothelial nitric oxide dependent mechanisms
… promotes vascular dilation, mucosal repair, and resolution of inflammation following intestinal ischemia and may be exploited as a novel therapeutic agent. It is unclear if H2S works through nitric oxide-dependent pathways in the intestine. We appreciated that H2S was able to improve …
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Investigating the Reconstitution and Function of Peritoneal Cavity Macrophages after LPS-induced Peritonitis
The tissue-resident macrophages of the peritoneum are sentinel immune cells, in constant motion within the serous fluid of the abdomen. Like most tissue macrophages, the GATA6+ large peritoneal macrophages (LPMs) are responsible for the clearance and removal of pathogens that may break through the …
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The role of type I regulatory cells in regulating immune responses to influenza infection
The resolution of influenza A virus (IAV) infection requires T cell-dependent immune regulation. In severe cases, without appropriate control of the immune response, the inflammation resulting from respiratory viral infection can lead to pneumonia and death. It is known that regulatory T cells are …
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Supplementation of omega-3 fatty acids as a strategy to regulate postpartum inflammation in dairy cows
The objectives of this thesis were to 1) evaluate the impact of supplementing omega-3 (n3) fatty acids (FA) using calcium salts enriched in fish oil (Ca-FO) in the early postpartum period on the degree and resolution of inflammation using an induced acute inflammation model, and 2) test whether …
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Modulation of Inflammation Driven Wound Healing after Glaucoma Surgery
… contributors to ocular morbidity – all with myofibroblast transdifferentiation and pathognomonic scarring activity at their core. This thesis aims to revaluate the means by which dysregulated ocular wound healing is combated with evidence describing a novel strategy to mitigate its effects. A …
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Molecular and Cellular Mechanisms Responsible for Low-grade Stress and Inflammation Triggered By Super-low Dose Endotoxin
… 4 (TLR4) and triggers a cascade of events culminating in the release of pro- and anti-inflammatory cytokines and the activation of NF-κB. In contrast, super-low doses of LPS (1-100pg/ml) are able to trigger the persistent release of pro-inflammatory mediators while evading the …
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Regulation of Reparative Macrophage Transition by the B-cell Adapter for PI3K (BCAP)
… the original pathogenic insult. Transition of macrophages from a pro-inflammatory state to a reparative state, however, is vital for resolution of inflammation and return to homeostasis. The molecular players governing this transition remain poorly defined. Here, we find that the reparative …
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Mechanisms of inflammation resolution in a murine model of Lyme arthritis
… arthritis persists despite antibiotic clearance of Borrelia burgdorferi, indicating an underlying defect in inflammation resolution mechanisms. In the murine model of Lyme arthritis (mLA), B. burgdorferi infection of C3H/HeJ mice induces a self-limiting arthritis, allowing the study of both the …
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Corneal Wound Healing: Cells and Molecules
… growth factors that promote wound healing, resolution of the inflammatory response (i.e., PMN clearance) is also needed to restore corneal homeostasis. This dissertation evaluated mechanisms regulating platelet recruitment after corneal injury, PMN migration in the abraded mouse corneal …
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Impact of cationic host defence peptide LL-37 on human neutrophil death and inflammatory responses
… Neutrophils (PMN) are the main reservoir of cathelicidins and play key roles in first line defence against infection. The appropriate regulation of PMN function, death, and clearance is critical to innate immunity, and the efferocytosis of apoptotic PMN, in contrast to necrotic cells, is …
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TARGETING THE NRF2/KEAP1 INTERACTION
… interaction (PPI) regulates activity of the Nrf2 antioxidant and anti-inflammatory pathway. The transcription factor Nrf2 has been found to be a key mediator in the resolution of inflammation and the progression of chronic diseases. Most known inducers of the Nrf2 pathway act by …
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Identifying Key Regulators of the Immune/Inflammatory Response for Developing Anticonvulsive and Antiepileptogenic Approaches
… There are no treatments for modifying the course of the disease, improving prognosis. Another unmet need is the absence of biomarkers able to identify patients at risk of developing epilepsy or with a progressive disease. Among the potential pathways for attaining these unmet needs, we focused on …
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TREM-2 Expression and Regulation in Inflammation and Ischaemia
… in myeloid cells. TREM-2 is involved in the resolution of inflammation through dampening Toll-like receptor (TLR) induced pro-inflammatory cytokine secretion and phagocytic functions. It is increased in inflammatory conditions including rheumatoid arthritis and stroke and also in wound …
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PRG4/CD44/PP2A Signaling Axis: A Significant Regulator of Gout Arthritis
… deposition in joints leading to activation of synovial resident macrophages and downstream production of interleukin-1b (IL-1b). Xanthine oxidase (XO) catalyzes purines into uric acid (UA) and reactive oxygen species (ROS) that activate NLRP3 inflammasome. Protein phosphatase-2A (PP2A) may …
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Signaling Cross-Talk Regulating the Expression of Arginase 1 in Murine Macrophages
Macrophages can be activated by a variety of extracellular signals to polarize to either the M1 (inflammatory and antimicrobial) or to the M2 (wound repair and inflammation resolution) phenotype. Expression of arginase 1 in macrophages is a key marker of the M2 phenotype. Arginase 1 expression is …
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Suppression of LPS-induced cytokines/chemokines production by CXCL1 siRNA
… bacteria induces initiation and progression of periodontal disease via factors such as NF-κB, TNF-α, IL-1β, and CXCL1. Down -regulation of these inflammatory mediators induced by periodontal bacteria through inhibitors may result in inhibition or resolution of inflammation and subsequent …
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Molecular mechanisms responsible for the dynamic modulation of macrophage responses to varying dosages of lipopolysaccharide
… depends for its effectiveness on the function of specialized pattern recognition receptors which enable it to target pathogens for destruction on the basis of conserved molecular patterns such as flagellin or lipopolysaccharide (LPS). Specifically, LPS is recognized by the Toll-like receptor 4 …
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A Mathematical-Experimental Strategy to Decode the Complex Molecular Basis for Neutrophil Migratory Decision-Making
… are the innate immune system's first line of defense in response to an infection. During an infection in the tissue, chemical cues called chemoattractants are released, which signal neutrophils to exit circulation and enter the tissue. Once in the tissue, neutrophils directionally migrate …
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Role of Fas/FasL, inflammatory mediators and LPS-activated macrophages in human neutrophil apoptosis
… the first haemopoetic cell to arrive at the site of infection. In acute respiratory distress syndrome (ARDS), dense neutrophilic infiltrates are found in the lung in response to bacterial infection as well as generalised inflammatory stimuli, such as pancreatitis. At sites of infection, …
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