Implications of the interactions between genetic background and dietary phosphorus on porcine muscle

<p>Phosphate (P) is an essential nutrient for both muscular and skeletal growth. Because the sources of dietary P in contemporary swine diets are poorly available for the simple stomach animals, inorganic phosphate sources are supplemented to these diets to prevent P deficiency. However, with the identification of P as one of the main polluting nutrients in fresh water system and soil, environmental concern and costs associated with P supplementation have led researchers to minimize the amount of P added to swine diets. Despite the vast amount of work conducted in this area, little research has examined the genetic mechanisms underlying the control of P utilization. Lack of understanding of the molecular response of skeletal muscle to dietary P and the influence of genetics has hindered our understanding of P homeostatic mechanisms. The objectives of my PhD research are to identify changes in gene expression in growing porcine muscle because of dietary P and genetic background and the interaction between dietary P and genetic background to examine the effects of decreasing dietary P intake and genetic background on the carcass characteristics and meat quality, and examine the impact of P deficiency hormonal profiles on the proliferation and differentiation of satellite cells isolated from young pigs. Elucidating the molecular and genetic mechanisms underlying P utilization by muscle tissue could lead to strategies to increase the efficiency of growth in domestic animals while doing so in a more environmentally friendly manner.</p>

Name thesis:degree_name

Doctor of Philosophy

Level thesis:degree_level

dissertation

Department dc:contributor.department

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology (LAS)

Year dc:date.issued

2007

Author dc:creator

• Qu, Ani

Advisors dc:contributor.advisor

• Chad Stahl
• Donald Beitz

Language dc:language.iso

en

DOI

https://doi.org/10.31274/rtd-180813-17184

Identifier

archive/lib.dr.iastate.edu/rtd/15989/

OAI identifier oai:identifier

oai:dr.lib.iastate.edu:20.500.12876/69677