Phosphate (P) is an essential nutrient for both muscular and skeletal growth. Because the sources of dietary P in contemporary swine diets are poorly available for the simple stomach animals, inorganic phosphate sources are supplemented to these diets to prevent P deficiency. However, with the identification of P as one of the main polluting nutrients in fresh water system and soil, environmental concern and costs associated with P supplementation have led researchers to minimize the amount of P added to swine diets. Despite the vast amount of work conducted in this area, little research has examined the genetic mechanisms underlying the control of P utilization. Lack of understanding of the molecular response of skeletal muscle to dietary P and the influence of genetics has hindered our understanding of P homeostatic mechanisms. The objectives of my PhD research are to identify changes in gene expression in growing porcine muscle because of dietary P and genetic background and the interaction between dietary P and genetic background to examine the effects of decreasing dietary P intake and genetic background on the carcass characteristics and meat quality, and examine the impact of P deficiency hormonal profiles on the proliferation and differentiation of satellite cells isolated from young pigs. Elucidating the molecular and genetic mechanisms underlying P utilization by muscle tissue could lead to strategies to increase the efficiency of growth in domestic animals while doing so in a more environmentally friendly manner.
","abstract_html":"<p>Phosphate (P) is an essential nutrient for both muscular and skeletal growth. Because the sources of dietary P in contemporary swine diets are poorly available for the simple stomach animals, inorganic phosphate sources are supplemented to these diets to prevent P deficiency. However, with the identification of P as one of the main polluting nutrients in fresh water system and soil, environmental concern and costs associated with P supplementation have led researchers to minimize the amount of P added to swine diets. Despite the vast amount of work conducted in this area, little research has examined the genetic mechanisms underlying the control of P utilization. Lack of understanding of the molecular response of skeletal muscle to dietary P and the influence of genetics has hindered our understanding of P homeostatic mechanisms. The objectives of my PhD research are to identify changes in gene expression in growing porcine muscle because of dietary P and genetic background and the interaction between dietary P and genetic background to examine the effects of decreasing dietary P intake and genetic background on the carcass characteristics and meat quality, and examine the impact of P deficiency hormonal profiles on the proliferation and differentiation of satellite cells isolated from young pigs. Elucidating the molecular and genetic mechanisms underlying P utilization by muscle tissue could lead to strategies to increase the efficiency of growth in domestic animals while doing so in a more environmentally friendly manner.</p>","abstract_has_math":false,"creators":["Qu, Ani"],"institution":null,"degree_name":"Doctor of Philosophy","degree_level":"dissertation","degree_discipline":null,"degree_department":"Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology (LAS)","school":null,"contributors":[],"advisors":["Chad Stahl","Donald Beitz"],"committee_chairs":[],"committee_members":[],"year":2007,"date_issued":"2007-01-01","date_published":"2007-01-01","updated_at":"2026-07-24T02:38:57Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.31274/rtd-180813-17184"],"render_values":[{"text":"https://doi.org/10.31274/rtd-180813-17184","href":"https://doi.org/10.31274/rtd-180813-17184","code":true}]},{"key":"dc:identifier","label":"Identifier","values":["archive/lib.dr.iastate.edu/rtd/15989/"],"render_values":[{"text":"archive/lib.dr.iastate.edu/rtd/15989/","href":null,"code":true}]}]},"links":{"outbound_url":"https://dr.lib.iastate.edu/handle/20.500.12876/69677","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Chad Stahl","Donald Beitz"]},{"key":"dc:contributor.department","label":"Department","values":["Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology (LAS)"]},{"key":"dc:creator","label":"Author","values":["Qu, Ani"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2018-08-22T18:29:37.000"]},{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2020-06-30T07:48:52Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2020-06-30T07:48:52Z"]},{"key":"dc:date.issued","label":"Date","values":["2007-01-01"]},{"key":"dc:type","label":"Dc Type","values":["dissertation"]},{"key":"thesis:degree_level","label":"Degree Level","values":["dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["archive/lib.dr.iastate.edu/rtd/15989/"]},{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.31274/rtd-180813-17184"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://dr.lib.iastate.edu/handle/20.500.12876/69677"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Phosphate (P) is an essential nutrient for both muscular and skeletal growth. Because the sources of dietary P in contemporary swine diets are poorly available for the simple stomach animals, inorganic phosphate sources are supplemented to these diets to prevent P deficiency. However, with the identification of P as one of the main polluting nutrients in fresh water system and soil, environmental concern and costs associated with P supplementation have led researchers to minimize the amount of P added to swine diets. Despite the vast amount of work conducted in this area, little research has examined the genetic mechanisms underlying the control of P utilization. Lack of understanding of the molecular response of skeletal muscle to dietary P and the influence of genetics has hindered our understanding of P homeostatic mechanisms. The objectives of my PhD research are to identify changes in gene expression in growing porcine muscle because of dietary P and genetic background and the interaction between dietary P and genetic background to examine the effects of decreasing dietary P intake and genetic background on the carcass characteristics and meat quality, and examine the impact of P deficiency hormonal profiles on the proliferation and differentiation of satellite cells isolated from young pigs. Elucidating the molecular and genetic mechanisms underlying P utilization by muscle tissue could lead to strategies to increase the efficiency of growth in domestic animals while doing so in a more environmentally friendly manner.
"]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Implications of the interactions between genetic background and dietary phosphorus on porcine muscle"]}]}],"canonical_facts":{"dc:contributor.advisor":["Chad Stahl","Donald Beitz"],"dc:contributor.department":["Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology (LAS)"],"dc:creator":["Qu, Ani"],"dc:date":["2018-08-22T18:29:37.000"],"dc:date.accessioned":["2020-06-30T07:48:52Z"],"dc:date.available":["2020-06-30T07:48:52Z"],"dc:date.issued":["2007-01-01"],"dc:description.abstract":["Phosphate (P) is an essential nutrient for both muscular and skeletal growth. Because the sources of dietary P in contemporary swine diets are poorly available for the simple stomach animals, inorganic phosphate sources are supplemented to these diets to prevent P deficiency. However, with the identification of P as one of the main polluting nutrients in fresh water system and soil, environmental concern and costs associated with P supplementation have led researchers to minimize the amount of P added to swine diets. Despite the vast amount of work conducted in this area, little research has examined the genetic mechanisms underlying the control of P utilization. Lack of understanding of the molecular response of skeletal muscle to dietary P and the influence of genetics has hindered our understanding of P homeostatic mechanisms. The objectives of my PhD research are to identify changes in gene expression in growing porcine muscle because of dietary P and genetic background and the interaction between dietary P and genetic background to examine the effects of decreasing dietary P intake and genetic background on the carcass characteristics and meat quality, and examine the impact of P deficiency hormonal profiles on the proliferation and differentiation of satellite cells isolated from young pigs. Elucidating the molecular and genetic mechanisms underlying P utilization by muscle tissue could lead to strategies to increase the efficiency of growth in domestic animals while doing so in a more environmentally friendly manner.
"],"dc:format.mimetype":["application/pdf"],"dc:identifier":["archive/lib.dr.iastate.edu/rtd/15989/"],"dc:identifier.doi":["https://doi.org/10.31274/rtd-180813-17184"],"dc:identifier.uri":["https://dr.lib.iastate.edu/handle/20.500.12876/69677"],"dc:language.iso":["en"],"dc:title":["Implications of the interactions between genetic background and dietary phosphorus on porcine muscle"],"dc:type":["dissertation"],"thesis:degree_level":["dissertation"],"thesis:degree_name":["Doctor of Philosophy"]},"updated_at":"2026-07-24T02:38:57Z"}