A Ratiometric Probe for Rapid Evaluation of Transfer Hydrogenation Efficiency

The aim of this thesis is to design and synthesize a luminescent cyclometalated Ir(III) complex with ratiometric response to transfer hydrogenation reaction, intended for better understanding and quantifying the Small-Molecule Intracellular Metal Catalysts (SIMCats) efficiency. Chapter 1 gives an introduction to luminescent probes, cyclometalated Ir complexes, transfer hydrogenation reaction, and SIMCats. It provides background knowledge and shows how we designed the ratiometric Ir complex (RIC). Chapter two shows the experimental procedure and results from synthesis, characterization, photophysical properties studies, and the transfer hydrogenation studies using a plate reader. The RIC575 probe coverts to RIC525 upon reduction, exhibiting a 50 nm hypsochromic shift in its emission maximum. This hypsochromic shift was later proved to be significant enough for ratiometric quantification. 10 different Cp*Ir catalysts were study with RIC575 using well plate and plate reader.

Name thesis:degree_name

Master of Science

Level thesis:degree_level

Masters

Discipline thesis:degree_discipline

Chemistry

Grantor

University of Houston

Year dc:date.issued

2023

Author dc:creator

• Young, Yen An

Advisor dc:contributor.advisor

• Do, Loi H.

Committee members dc:contributor.committeemember

• Carrow, Bradley P.
• Comito, Robert J.
• Şen, Mehmet
• Teets, Thomas S.

• ratiometric probes
• cyclometalated iridium complex
• small-molecule intracellular metal catalysts
• transfer hydrogenation reaction

Statement dc:rights

• The author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s).

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/10657/16106

OAI identifier oai:identifier

oai:uh-ir.tdl.org:10657/16106