{"id":{"repo_id":"houston","oai_identifier":"oai:uh-ir.tdl.org:10657/16106"},"canonical_url":"https://search.dev.ndltd.org/etd/houston/oai:uh-ir.tdl.org:10657/16106","repository":{"repo_id":"houston","name":"University of Houston","base_url":"https://uh-ir.tdl.org/server/oai/request"},"display":{"title":"A Ratiometric Probe for Rapid Evaluation of Transfer Hydrogenation Efficiency","abstract":"The aim of this thesis is to design and synthesize a luminescent cyclometalated Ir(III) complex with ratiometric response to transfer hydrogenation reaction, intended for better understanding and quantifying the Small-Molecule Intracellular Metal Catalysts (SIMCats) efficiency. Chapter 1 gives an introduction to luminescent probes, cyclometalated Ir complexes, transfer hydrogenation reaction, and SIMCats. It provides background knowledge and shows how we designed the ratiometric Ir complex (RIC). Chapter two shows the experimental procedure and results from synthesis, characterization, photophysical properties studies, and the transfer hydrogenation studies using a plate reader. The RIC575 probe coverts to RIC525 upon reduction, exhibiting a 50 nm hypsochromic shift in its emission maximum. This hypsochromic shift was later proved to be significant enough for ratiometric quantification. 10 different Cp*Ir catalysts were study with RIC575 using well plate and plate reader.","abstract_html":"The aim of this thesis is to design and synthesize a luminescent cyclometalated Ir(III) complex with ratiometric response to transfer hydrogenation reaction, intended for better understanding and quantifying the Small-Molecule Intracellular Metal Catalysts (SIMCats) efficiency. Chapter 1 gives an introduction to luminescent probes, cyclometalated Ir complexes, transfer hydrogenation reaction, and SIMCats. It provides background knowledge and shows how we designed the ratiometric Ir complex (RIC). Chapter two shows the experimental procedure and results from synthesis, characterization, photophysical properties studies, and the transfer hydrogenation studies using a plate reader. The RIC575 probe coverts to RIC525 upon reduction, exhibiting a 50 nm hypsochromic shift in its emission maximum. This hypsochromic shift was later proved to be significant enough for ratiometric quantification. 10 different Cp*Ir catalysts were study with RIC575 using well plate and plate reader.","abstract_has_math":false,"creators":["Young, Yen An"],"institution":"University of Houston","degree_name":"Master of Science","degree_level":"Masters","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":[],"advisors":["Do, Loi H."],"committee_chairs":[],"committee_members":["Carrow, Bradley P.","Comito, Robert J.","Şen, Mehmet","Teets, Thomas S."],"year":2023,"date_issued":"2023-12","date_published":"2023-12","updated_at":"2026-07-24T02:33:06Z","subjects":["ratiometric probes","cyclometalated iridium complex","small-molecule intracellular metal catalysts","transfer hydrogenation reaction"],"languages":["eng"],"rights":["The author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s)."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/10657/16106","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Do, Loi H."]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Carrow, Bradley P.","Comito, Robert J.","Şen, Mehmet","Teets, Thomas S."]},{"key":"dc:creator","label":"Author","values":["Young, Yen An"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2024-01-24T19:30:17Z"]},{"key":"dc:date.issued","label":"Date","values":["2023-12"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Houston"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ratiometric probes","cyclometalated iridium complex","small-molecule intracellular metal catalysts","transfer hydrogenation reaction"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["The author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s)."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10657/16106"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The aim of this thesis is to design and synthesize a luminescent cyclometalated Ir(III) complex with ratiometric response to transfer hydrogenation reaction, intended for better understanding and quantifying the Small-Molecule Intracellular Metal Catalysts (SIMCats) efficiency. Chapter 1 gives an introduction to luminescent probes, cyclometalated Ir complexes, transfer hydrogenation reaction, and SIMCats. It provides background knowledge and shows how we designed the ratiometric Ir complex (RIC). Chapter two shows the experimental procedure and results from synthesis, characterization, photophysical properties studies, and the transfer hydrogenation studies using a plate reader. The RIC575 probe coverts to RIC525 upon reduction, exhibiting a 50 nm hypsochromic shift in its emission maximum. This hypsochromic shift was later proved to be significant enough for ratiometric quantification. 10 different Cp*Ir catalysts were study with RIC575 using well plate and plate reader."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["A Ratiometric Probe for Rapid Evaluation of Transfer Hydrogenation Efficiency"]}]}],"canonical_facts":{"dc:contributor.advisor":["Do, Loi H."],"dc:contributor.committeemember":["Carrow, Bradley P.","Comito, Robert J.","Şen, Mehmet","Teets, Thomas S."],"dc:creator":["Young, Yen An"],"dc:date.accessioned":["2024-01-24T19:30:17Z"],"dc:date.issued":["2023-12"],"dc:description.abstract":["The aim of this thesis is to design and synthesize a luminescent cyclometalated Ir(III) complex with ratiometric response to transfer hydrogenation reaction, intended for better understanding and quantifying the Small-Molecule Intracellular Metal Catalysts (SIMCats) efficiency. Chapter 1 gives an introduction to luminescent probes, cyclometalated Ir complexes, transfer hydrogenation reaction, and SIMCats. It provides background knowledge and shows how we designed the ratiometric Ir complex (RIC). Chapter two shows the experimental procedure and results from synthesis, characterization, photophysical properties studies, and the transfer hydrogenation studies using a plate reader. The RIC575 probe coverts to RIC525 upon reduction, exhibiting a 50 nm hypsochromic shift in its emission maximum. This hypsochromic shift was later proved to be significant enough for ratiometric quantification. 10 different Cp*Ir catalysts were study with RIC575 using well plate and plate reader."],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["https://hdl.handle.net/10657/16106"],"dc:language.iso":["eng"],"dc:rights":["The author of this work is the copyright owner. UH Libraries and the Texas Digital Library have their permission to store and provide access to this work. Further transmission, reproduction, or presentation of this work is prohibited except with permission of the author(s)."],"dc:subject":["ratiometric probes","cyclometalated iridium complex","small-molecule intracellular metal catalysts","transfer hydrogenation reaction"],"dc:title":["A Ratiometric Probe for Rapid Evaluation of Transfer Hydrogenation Efficiency"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Masters"],"thesis:degree_name":["Master of Science"],"thesis:institution_name":["University of Houston"]},"updated_at":"2026-07-24T02:33:06Z"}