Modeling and computer simulation of tumor growth and tumor response to radiotherapy

In radiotherapy, total dose and time-dose patterns are currently chosen according to the clinical expertise of the radiation oncologist. To aid radiation oncologists in the treatment planning process, it is important to quantitatively assess tumor response to irradiation. The objective of this work is to devise a cellular radiobiological model and to develop three-dimensional simulation methods that allow simulation of tumors with clinically relevant sizes. Simulations of unperturbed tumor proliferation are compared to corresponding experimental growth curves in vivo. The most important radiobiological parameters are identified and their influence on tumor growth and tumor response to irradiation is quantified. Total doses needed by conventional and accelerated fractionation schemes for tumor control are given for different radiobiological parameters, such as cell cycle time, growth fraction and radiosensitivity.

Level thesis:degree_level

thesis.doctoral

Grantor dc:publisher

Universität Heidelberg

Year

2001

Author dc:creator

• Borkenstein, Klaus

Contributors dc:contributor

• Schlegel, Wolfgang,

Repository record source_url

http://www.ub.uni-heidelberg.de/archiv/1809

OAI identifier oai:identifier

oai:archiv.ub.uni-heidelberg.de:1809