{"id":{"repo_id":"heid-diss","oai_identifier":"oai:archiv.ub.uni-heidelberg.de:1809"},"canonical_url":"https://search.dev.ndltd.org/etd/heid-diss/oai:archiv.ub.uni-heidelberg.de:1809","repository":{"repo_id":"heid-diss","name":"Universität Heidelberg","base_url":"http://archiv.ub.uni-heidelberg.de/volltextserver/cgi/oai2"},"display":{"title":"Modeling and computer simulation of tumor growth and tumor response to radiotherapy","abstract":"In radiotherapy, total dose and time-dose patterns are currently chosen according to the clinical expertise of the radiation oncologist. To aid radiation oncologists in the treatment planning process, it is important to quantitatively assess tumor response to irradiation. The objective of this work is to devise a cellular radiobiological model and to develop three-dimensional simulation methods that allow simulation of tumors with clinically relevant sizes. Simulations of unperturbed tumor proliferation are compared to corresponding experimental growth curves in vivo. The most important radiobiological parameters are identified and their influence on tumor growth and tumor response to irradiation is quantified. Total doses needed by conventional and accelerated fractionation schemes for tumor control are given for different radiobiological parameters, such as cell cycle time, growth fraction and radiosensitivity.","abstract_html":"In radiotherapy, total dose and time-dose patterns are currently chosen according to the clinical expertise of the radiation oncologist. To aid radiation oncologists in the treatment planning process, it is important to quantitatively assess tumor response to irradiation. The objective of this work is to devise a cellular radiobiological model and to develop three-dimensional simulation methods that allow simulation of tumors with clinically relevant sizes. Simulations of unperturbed tumor proliferation are compared to corresponding experimental growth curves in vivo. The most important radiobiological parameters are identified and their influence on tumor growth and tumor response to irradiation is quantified. Total doses needed by conventional and accelerated fractionation schemes for tumor control are given for different radiobiological parameters, such as cell cycle time, growth fraction and radiosensitivity.","abstract_has_math":false,"creators":["Borkenstein, Klaus"],"institution":"Universität Heidelberg","degree_name":null,"degree_level":"thesis.doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Schlegel, Wolfgang,"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2001,"date_issued":"2001-11-07","date_published":"2001-11-07","updated_at":"2026-07-24T02:29:09Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://www.ub.uni-heidelberg.de/archiv/1809","outbound_label":"Repository record","outbound_source":"source_url"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Schlegel, Wolfgang,"]},{"key":"dc:creator","label":"Author","values":["Borkenstein, Klaus"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:publisher","label":"Institution","values":["Universitätsbibliothek Heidelberg"]},{"key":"dc:type","label":"Dc Type","values":["doctoralThesis"]},{"key":"thesis:degree_level","label":"Degree Level","values":["thesis.doctoral"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Universität Heidelberg"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["In radiotherapy, total dose and time-dose patterns are currently chosen according to the clinical expertise of the radiation oncologist. To aid radiation oncologists in the treatment planning process, it is important to quantitatively assess tumor response to irradiation. The objective of this work is to devise a cellular radiobiological model and to develop three-dimensional simulation methods that allow simulation of tumors with clinically relevant sizes. Simulations of unperturbed tumor proliferation are compared to corresponding experimental growth curves in vivo. The most important radiobiological parameters are identified and their influence on tumor growth and tumor response to irradiation is quantified. Total doses needed by conventional and accelerated fractionation schemes for tumor control are given for different radiobiological parameters, such as cell cycle time, growth fraction and radiosensitivity."]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Modeling and computer simulation of tumor growth and tumor response to radiotherapy","Modellierung und Computersimulation des Tumorwachstums und der Tumorantwort auf Strahlentherapie"]}]}],"canonical_facts":{"dc:contributor":["Schlegel, Wolfgang,"],"dc:creator":["Borkenstein, Klaus"],"dc:description.abstract":["In radiotherapy, total dose and time-dose patterns are currently chosen according to the clinical expertise of the radiation oncologist. To aid radiation oncologists in the treatment planning process, it is important to quantitatively assess tumor response to irradiation. The objective of this work is to devise a cellular radiobiological model and to develop three-dimensional simulation methods that allow simulation of tumors with clinically relevant sizes. Simulations of unperturbed tumor proliferation are compared to corresponding experimental growth curves in vivo. The most important radiobiological parameters are identified and their influence on tumor growth and tumor response to irradiation is quantified. Total doses needed by conventional and accelerated fractionation schemes for tumor control are given for different radiobiological parameters, such as cell cycle time, growth fraction and radiosensitivity."],"dc:format.medium":["application/pdf"],"dc:publisher":["Universitätsbibliothek Heidelberg"],"dc:title":["Modeling and computer simulation of tumor growth and tumor response to radiotherapy","Modellierung und Computersimulation des Tumorwachstums und der Tumorantwort auf Strahlentherapie"],"dc:type":["doctoralThesis"],"thesis:degree_level":["thesis.doctoral"],"thesis:institution_name":["Universität Heidelberg"]},"updated_at":"2026-07-24T02:29:09Z"}