ΓΟΝΙΔΙΑΚΗ ΕΚΦΡΑΣΗ ΔΙΕΓΕΡΜΕΝΩΝ ΑΝΘΡΩΠΙΝΩΝ Τ-ΛΕΜΦΟΚΥΤΤΑΡΩΝ: ΡΥΘΜΙΣΗ ΤΗΣ ΕΚΦΡΑΣΗΣ ΤΟΥ ΓΟΝΙΔΙΟΥ 2 ΚΑΤΑ ΤΗ ΔΙΑΡΚΕΙΑ ΤΟΥ ΚΥΤΤΑΡΙΚΟΥ ΚΥΚΛΟΥ

THE OBJECT OF THIS STUDY WAS TO RESEARCH INTO THE CELL CYCLE AND REGULATION OF THE CD2 GLUE EXPRESSION IN PHA STIMULATED HUMAN PERIPHERAL BLOOD T-LYMPHOCYTES.THE ACCURATE POSITION OF STIMULATED LYMPHOCYTES IN THE CELL CYCLE WAS DETERMINED BY USING THE "PREMATURE CHROMOSOME CONDENSATION" METHOD (PCC), WHICH OFFERS THE POSSIBILITY OF STUDYING THE DISTRIBUTION OF LYMPHOCYTES IN G1, S AND G2 PHASES. THE RESULTS OF THIS STUDY SUPPORT THE ASPECT THAT THE CD2 GENE EXPRESSION SEEMS TO BE CONTROLLED BY A COMBINATION OF REGULATORY MECHANISMS WHICH ARE ACTIVE AT TRANSCRIPTIONAL, POST TRANSCRIPTIONAL AND POST TRANSLATIONAL LEVEL. THE POSSIBILITY OF REGULATORY MECHANISMS AT OTHER LEVELS TOO, CANNOT BE EXCLUDED. THE CD2 GENE IS ONE OF A LARGE GROUP OF PHA INDUCIBLE GENES. THE FLUCTUATION OF CD2-MRNA THROUGH THE CELL CYCLE SUGGESTS THAT CD2 GENE IS PROBABLY EXPRESSED IN A CELL CYCLE DEPENDENT MANNER (MAINLY THROUGH G1 PHASE). FURTHERMORE THE INCREASED EXPRESSION OF THE CD2 GENE (MULTILAYER ROSE BE USED AS A MARKER OF CELL CYCLE PROGRESSION IN THE TRANSITION OF T-LYMPHOCYTES FROM GO TO S PHASE.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1991

Authors dc:creator

• Kitsiou, Paraskevi
• Κίτσιου, Παρασκευή

• CD2 ΓΟΝΙΔΙΟ
• CD2 ΚΥΤΤΑΡΟΕΠΙΦΑΝΕΙΑΚΟ ΑΝΤΙΓΟΝΟ
• ΑΝΘΡΩΠΙΝΑ Τ-ΛΕΜΦΟΚΥΤΤΑΡΑ
• Γονιδιακή έκφραση
• Γονιδιακή ρύθμιση
• Ε-ΡΟΔΑΚΑΣ
• Κυτταρικός κύκλος
• ΠΡΟΩΡΗ ΧΡΩΜΟΣΩΜΑΤΙΚΗ ΣΥΜΠΥΚΝΩΣΗ
• Φυτοαιμαγλουτινίνη (PHA)
• CD2 CELL SURFACE ANTIGEN
• CD2 GENE
• Cell cycle
• E-ROSETTE
• Gene expression
• Gene regulation
• Human T-lympocytes
• Phytohemagglutinin (PHA)
• Premature chromosome condensation
• Φυσικές Επιστήμες
• Βιολογία
• Natural Sciences
• Biological Sciences

Language dc:language

gre

Identifier

10.12681/eadd/1755

OAI identifier oai:identifier

oai:10442/1755