Μελέτη ανασυνδυασμού DNA σε υπερπλασίες του λεμφικού συστήματος και λεμφώματα

We performed genotypic analysis of 26 cases diagnosed mainly as lymphoid reactive processes – 22 cases – and 4 borderline cases, for the purpose of investigating the possible existence of clonal gene rearrangements. Such rearrangements have been detected in a number of clinically benign entities but so far they have not been reported in clear reactive processes. We report here that 5/22 reactive processes analysed with IG and TCR gene probes contain clonal gene rearrangements and do so 2/4 borderline cases. These findings bear implications concerning the mechanism of lymphomatogenesis as well as the diagnosis of disease. Furthermore, we analysed 30 cases of malignant lymphoproliferations-Hodgkin’s disease and non-Hodgkin’s lymphomas - and no clonal rearrangements were detected in Hodgkin’s disease with high numbe of Reed-Sternberg cells and in subtypes of peripheral T-cell lymphomas. The biological significance of these data relies on a possible correlation between absence of gene rearrangements and the specific cell phenotypes.

Grantor dc:publisher

University of Patras

Year dc:date

1990

Author dc:creator

• Ορφανός, Βασίλειος

• Αντιδραστικές λεμφικές υπερπλασίες
• Γονίδια ανοσοσφαιρίνων
• Γονίδια υποδοχέων Τ-λεμφοκυττάρων
• Γονιδιακοί ανασυνδυασμοί
• Μη - hodgkin λεμφώματα
• Νόσος Hodgkin
• Gene rearrangements
• Hodgkin's disease
• IG- and TCR genes
• Lymphoid reactive processes
• Non-Hodgkin's lymphoma
• Ιατρική και Επιστήμες Υγείας
• Βασική Ιατρική
• Medical and Health Sciences
• Basic Medicine

Language dc:language

gre

Identifier

10.12681/eadd/1728

OAI identifier oai:identifier

oai:10442/1728