Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"T cell lymphomas"”.
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Expression of Follicular Helper T-cell Markers in Primary Cutaneous T-cell Lymphoma
… and objectives: A distinct subset of T helper cells, named follicular helper T- (TFH) cells, have been recently described. The TFH-cells can be identified on the basis of the expression of several markers including: the chemokine CXCL13; the costimulatory molecules PD-1 and inducible …
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Analisi genetico-molecolare dei linfomi a cellule T periferiche
Molecular profiling of Peripheral T-cell lymphomas not otherwise specified Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of tumors that the WHO classification basically subdivides into specified and not otherwise specified (NOS). In Western countries, they represent around 12% of …
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Role of autocrine growth factors in the tumorigenic transformation of T cells
… hypothesis that tumorigenic transformation of T cells may result from aberrant regulation of autocrine growth factor production. We describe for the first time characterization of several normal T cell lines that underwent spontaneous transformation resulting from constitutive expression of …
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Immunophenotypic classification of canine malignant lymphoma in formalin-fixed, paraffin wax-embedded specimens using CD3 and CD79a cell markers
… processing. Immunophenotyping, using CD3 (T cell) and CD79a (8cell) markers, was carried out on the same sections. Intermediate grade lymphomas were the largest category (49.5%), with 16.5%high grade lymphomas. More than half (53.3%) of the lymphomas were of 8 cell immuno phenotype, and 36.5% …
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Μελέτη ανασυνδυασμού DNA σε υπερπλασίες του λεμφικού συστήματος και λεμφώματα
… disease and non-Hodgkin’s lymphomas - and no clonal rearrangements were detected in Hodgkin’s disease with high numbe of Reed-Sternberg cells and in subtypes of peripheral T-cell lymphomas. The biological significance of these data relies on a possible correlation between …
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INSIGHTS ON THE CROSSTALK BETWEEN THE IMMUNE SYSTEMAND CANCER: IMMUNE CHECKPOINT MOLECULES AND LYMPHOIDPOPULATIONS ASSESSMENT IN CANINE ROUND CELL TUMORS
… sentinel lymph nodes (SLNs) of dogs with mast cell tumors (MCTs). Regarding PD-L1, the project evaluated the expression of the surface membrane protein (mPD-L1) by means of flow cytometry (FC), mRNA by real-time qPCR, and soluble protein (sPD-L1) plasmatic concentrations by competitive ELISA in …
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Metabolic regulation in Phosphatase and tensin homologue (PTEN) null T cell lymphoma/leukaemia cells
Deletion of PTEN selectively in T cell progenitors in the thymus results in the rapid development of aggressive T cell lymphomas in a mouse model for T-ALL. We showed that PTEN-/- T cell lymphoma/leukaemia cells were metabolically active as they readily took up key nutrients. Thus, they had high …
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Identifying Children with Constitutional Mismatch Repair Deficiency (CMMR-D) Syndrome in the Expanding Lynch Syndrome population in Cape Town
… cancers, high-grade gliomas, non-Hodgkin T-cell lymphomas and leukaemias. It is characterized by biallelic germline mutation of one of four possible MMR genes resulting in loss of protein expression that can be identified by applying immunohistochemistry to formalin fixed paraffin embedded …
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THE ROLE OF THE TRANSCRIPTION FACTOR DEAF-1 IN PROSTATE FUNCTION
… develop prostate inflammation and prostate T-Cell lymphomas suggesting DEAF-1 haploinsuffciency produces a genetic defect in prostate function. The Deaf-1 knockout mice also develop lung and liver tumors and these data show a potential role of Deaf-1 in the molecular basis of tumor formation. …
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Type I Insulin-Like Growth Factor Receptor Tyrosine Kinase As A Molecular Target In Mantle Cell Lymphoma
Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoid malignancy representing 5-10% of all non-Hodgkin’s lymphomas. It is distinguished by the t(11;14)(q13;q32) chromosomal translocation that juxtaposes the proto-oncogene CCND1, which encodes cyclin D1 at 11q13 to the IgH gene at 14q32. MCL …
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The AMPK signalling pathway in cancer and DNA damage
… energy homeostasis and metabolism, both at the cellular and at the whole body level. It acts as a cellular fuel gauge, sensing changes in AMP: ATP or ADP: ATP ratios. Once activated by energy deficit, AMPK switches on catabolic processes, generating ATP, and inhibits biosynthetic processes, …
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ΜΗΧΑΝΙΣΜΟΙ ΟΓΚΟΓΕΝΕΣΗΣ ΔΙΑ ΤΟΥ ΛΕΥΧΑΙΜΟΓΟΝΟΥ ΙΟΥ ΤΟΥ MOLONEY (MOMULV)
… IN RATS AND MICE IN WHICH IT INDUCES THYMIC LYMPHOMAS. THESE LYMPHOMAS ARE CLONAL TUMORS AND APPEAR FOUR TO SIX MONTHS FOLLOWING VIRUS INOCULATION. THE PHENOTYPE OF THESE TUMORS CORRESPONDS TO ALL THE STAGES OF T CELL DIFFERENTIATION. THE PROCESS OF ONCOGENESIS IN BOTH ITS EARLY AND LATE …