Απομόνωση και δομή προθυμοσίνης α αιγός και συμβολή στη διερεύνηση της βιολογικής δραστικότητας της προθυμοσίνης α

The primary sequence of goat prothymosin a exhibits a high degree of homology to the sequences of prothymosin a from the other mammalian species. The highest levels of prothymosin a are found in thymus and spleen, with significantly lower levels in non-lymphoid tissues. During development, the lymphoid tissue levels of rat prothymosin a are significantly altered with highest levels observed in newborn and prepubertal rats. Autoantibodies against prothymosin a were detected in 18% of the sera of patients with SLE. These antibodies recognize only the C-terminal portion of the molecule. Human monocytes incubated in complete culture medium with prothymosin a produce increased quantities of thymosin a, (the N-terminal peptide fragment of prothymosin a) in the culture supernatants.

Grantor dc:publisher

University of Ioannina

Year dc:date

1991

Authors dc:creator

• Frillingos, Stathis
• Φριλίγγος, Ευστάθιος

• Αίγα
• Ανάπτυξη
• Απομόνωση
• Αυτοαντισώματα
• Ενεργοποιημένα μονοκύτταρα
• Θυμοσίνη α
• Κατανομή σε ιστούς
• Προθυμοσίνη α
• Πρωτοταγής δομή
• Συστηματικός ερυθηματώδης λύκος ( ΣΕΛ)
• Activated monocytes
• Autoantibodies
• Development
• Goat
• Isolation
• Primary structure
• Prothymosin a
• Systemic lupus erythematosus ( SLE)
• Thymosin a
• Tissue distribution
• Φυσικές Επιστήμες
• Βιολογία
• Ιατρική και Επιστήμες Υγείας
• Επιστήμες Υγείας
• Natural Sciences
• Biological Sciences
• Medical and Health Sciences
• Health Sciences

Language dc:language

gre

Identifier

10.12681/eadd/1702

OAI identifier oai:identifier

oai:10442/1702