{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1702"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1702","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"Απομόνωση και δομή προθυμοσίνης α αιγός και συμβολή στη διερεύνηση της βιολογικής δραστικότητας της προθυμοσίνης α","abstract":"The primary sequence of goat prothymosin a exhibits a high degree of homology to the sequences of prothymosin a from the other mammalian species. The highest levels of prothymosin a are found in thymus and spleen, with significantly lower levels in non-lymphoid tissues. During development, the lymphoid tissue levels of rat prothymosin a are significantly altered with highest levels observed in newborn and prepubertal rats. Autoantibodies against prothymosin a were detected in 18% of the sera of patients with SLE. These antibodies recognize only the C-terminal portion of the molecule. Human monocytes incubated in complete culture medium with prothymosin a produce increased quantities of thymosin a, (the N-terminal peptide fragment of prothymosin a) in the culture supernatants.","abstract_html":"The primary sequence of goat prothymosin a exhibits a high degree of homology to the sequences of prothymosin a from the other mammalian species. The highest levels of prothymosin a are found in thymus and spleen, with significantly lower levels in non-lymphoid tissues. During development, the lymphoid tissue levels of rat prothymosin a are significantly altered with highest levels observed in newborn and prepubertal rats. Autoantibodies against prothymosin a were detected in 18% of the sera of patients with SLE. These antibodies recognize only the C-terminal portion of the molecule. Human monocytes incubated in complete culture medium with prothymosin a produce increased quantities of thymosin a, (the N-terminal peptide fragment of prothymosin a) in the culture supernatants.","abstract_has_math":false,"creators":["Frillingos, Stathis","Φριλίγγος, Ευστάθιος"],"institution":"University of Ioannina","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1991,"date_issued":"1991","date_published":"1991","updated_at":"2026-07-24T02:25:05Z","subjects":["Αίγα","Ανάπτυξη","Απομόνωση","Αυτοαντισώματα","Ενεργοποιημένα μονοκύτταρα","Θυμοσίνη α","Κατανομή σε ιστούς","Προθυμοσίνη α","Πρωτοταγής δομή","Συστηματικός ερυθηματώδης λύκος ( ΣΕΛ)","Activated monocytes","Autoantibodies","Development","Goat","Isolation","Primary structure","Prothymosin a","Systemic lupus erythematosus ( SLE)","Thymosin a","Tissue distribution","Φυσικές Επιστήμες","Βιολογία","Ιατρική και Επιστήμες Υγείας","Επιστήμες Υγείας","Natural Sciences","Biological Sciences","Medical and Health Sciences","Health Sciences"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1702"],"render_values":[{"text":"10.12681/eadd/1702","href":"https://doi.org/10.12681/eadd/1702","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1702","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Frillingos, Stathis","Φριλίγγος, Ευστάθιος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1991"]},{"key":"dc:publisher","label":"Institution","values":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Αίγα","Ανάπτυξη","Απομόνωση","Αυτοαντισώματα","Ενεργοποιημένα μονοκύτταρα","Θυμοσίνη α","Κατανομή σε ιστούς","Προθυμοσίνη α","Πρωτοταγής δομή","Συστηματικός ερυθηματώδης λύκος ( ΣΕΛ)","Activated monocytes","Autoantibodies","Development","Goat","Isolation","Primary structure","Prothymosin a","Systemic lupus erythematosus ( SLE)","Thymosin a","Tissue distribution","Φυσικές Επιστήμες","Βιολογία","Ιατρική και Επιστήμες Υγείας","Επιστήμες Υγείας","Natural Sciences","Biological Sciences","Medical and Health Sciences","Health Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1702","http://hdl.handle.net/10442/hedi/1702"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The primary sequence of goat prothymosin a exhibits a high degree of homology to the sequences of prothymosin a from the other mammalian species. The highest levels of prothymosin a are found in thymus and spleen, with significantly lower levels in non-lymphoid tissues. During development, the lymphoid tissue levels of rat prothymosin a are significantly altered with highest levels observed in newborn and prepubertal rats. Autoantibodies against prothymosin a were detected in 18% of the sera of patients with SLE. These antibodies recognize only the C-terminal portion of the molecule. Human monocytes incubated in complete culture medium with prothymosin a produce increased quantities of thymosin a, (the N-terminal peptide fragment of prothymosin a) in the culture supernatants.","Η προθυμοσίνη α αιγός παρουσιάζει πολύ μεγάλη ομολογία με τις προθυμοσίνες άλλων θηλαστικών, ως προς την πρωτοταγή δομή. Μεγαλύτερες συγκεντρώσεις προθυμοσίνης α περιέχουν οι λεμφικοί ιστοί (θύμος, σπλήνα) και μικρότερες οι μη λεμφικοί (πνεύμονες, νεφροί, ήπαρ). Οι συγκεντρώσεις προθυμοσίνης α των λεμφικών ιστών μεταβάλλονται κατά την ανάπτυξη, με μέγιστες τιμές σε προεφηβικές ηλικίες (τα πυρώματα αυτά έγιναν σε επίμυς). Αυτοαντισώματα έναντι προθυμοσίνης α ανιχνεύθηκαν σε ποσοστό 18% των ορών ασθενών με συστηματικό ερυθηματώδη λύκο, με εξειδίκευση για την c-πλευρά του μορίου. Επίδραση προθυμοσίνης α in vitro σε μονοκύτταρα οδηγεί σε παραγωγή αυξημένων ποσοτήτων θυμοσίνης α, (Ν-πλευράς του μορίου) στο υπερκείμενο της καλλιέργειας."]},{"key":"dc:title","label":"Title","values":["Απομόνωση και δομή προθυμοσίνης α αιγός και συμβολή στη διερεύνηση της βιολογικής δραστικότητας της προθυμοσίνης α","Isolation and structure of goat prothymosin a and contribution to the investigation of the biological activity of prothymocin a"]}]}],"canonical_facts":{"dc:creator":["Frillingos, Stathis","Φριλίγγος, Ευστάθιος"],"dc:date":["1991"],"dc:description":["The primary sequence of goat prothymosin a exhibits a high degree of homology to the sequences of prothymosin a from the other mammalian species. The highest levels of prothymosin a are found in thymus and spleen, with significantly lower levels in non-lymphoid tissues. During development, the lymphoid tissue levels of rat prothymosin a are significantly altered with highest levels observed in newborn and prepubertal rats. Autoantibodies against prothymosin a were detected in 18% of the sera of patients with SLE. These antibodies recognize only the C-terminal portion of the molecule. Human monocytes incubated in complete culture medium with prothymosin a produce increased quantities of thymosin a, (the N-terminal peptide fragment of prothymosin a) in the culture supernatants.","Η προθυμοσίνη α αιγός παρουσιάζει πολύ μεγάλη ομολογία με τις προθυμοσίνες άλλων θηλαστικών, ως προς την πρωτοταγή δομή. Μεγαλύτερες συγκεντρώσεις προθυμοσίνης α περιέχουν οι λεμφικοί ιστοί (θύμος, σπλήνα) και μικρότερες οι μη λεμφικοί (πνεύμονες, νεφροί, ήπαρ). Οι συγκεντρώσεις προθυμοσίνης α των λεμφικών ιστών μεταβάλλονται κατά την ανάπτυξη, με μέγιστες τιμές σε προεφηβικές ηλικίες (τα πυρώματα αυτά έγιναν σε επίμυς). Αυτοαντισώματα έναντι προθυμοσίνης α ανιχνεύθηκαν σε ποσοστό 18% των ορών ασθενών με συστηματικό ερυθηματώδη λύκο, με εξειδίκευση για την c-πλευρά του μορίου. Επίδραση προθυμοσίνης α in vitro σε μονοκύτταρα οδηγεί σε παραγωγή αυξημένων ποσοτήτων θυμοσίνης α, (Ν-πλευράς του μορίου) στο υπερκείμενο της καλλιέργειας."],"dc:identifier":["10.12681/eadd/1702","http://hdl.handle.net/10442/hedi/1702"],"dc:language":["gre"],"dc:publisher":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"],"dc:subject":["Αίγα","Ανάπτυξη","Απομόνωση","Αυτοαντισώματα","Ενεργοποιημένα μονοκύτταρα","Θυμοσίνη α","Κατανομή σε ιστούς","Προθυμοσίνη α","Πρωτοταγής δομή","Συστηματικός ερυθηματώδης λύκος ( ΣΕΛ)","Activated monocytes","Autoantibodies","Development","Goat","Isolation","Primary structure","Prothymosin a","Systemic lupus erythematosus ( SLE)","Thymosin a","Tissue distribution","Φυσικές Επιστήμες","Βιολογία","Ιατρική και Επιστήμες Υγείας","Επιστήμες Υγείας","Natural Sciences","Biological Sciences","Medical and Health Sciences","Health Sciences"],"dc:title":["Απομόνωση και δομή προθυμοσίνης α αιγός και συμβολή στη διερεύνηση της βιολογικής δραστικότητας της προθυμοσίνης α","Isolation and structure of goat prothymosin a and contribution to the investigation of the biological activity of prothymocin a"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:05Z"}