ΜΕΛΕΤΗ ΤΗΣ ΒΑΡΕΙΑΣ ΜΥΑΣΘΕΝΕΙΑΣ ΚΑΙ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΑΚΕΤΥΛΟΧΟΛΙΝΗΣ ΜΕ ΤΗΝ ΒΟΗΘΕΙΑ ΜΟΝΟΚΛΩΝΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ

MYASTHENIA GRAVIS (MG) IS A NEUROMUSCULAR DISORDER MANIFESTED BY WEAKNESS AND FATIGABILITY OF VOLUNTARY MUSCLES DUE MAINLY TO AUTOANTIBODY-MEDIATED LOSS OF ACETYLCHOLINE RECEPTOR (ACHR). ACHR IS A MEMBRANE GLYCOPROTEIN (M.W.-290,000) COMPOSED OF FIVE SUBUNITS IN THE MOLECULAR RATIO OF A2BΓΔ. ANTIBODY-MEDIATED ACHR LOSS IN MG IS CAUSED BY AT LEAST TWO MECHANISMS: (A) BIVALENT AND POLYVALENT ANTIBODIES CROSSLINK MEMBRANE-BOUND RECEPTORS RESULTING IN INCREASED RECEPTOR INTERNALIZATION AND DEGRADATION RATE (ANTIGENIC MODULATION). (B) COMPLEMENT BINDS TO THE ANTIBODIES WHICH ARE ATTACHED ON THE MEMBRANE ACHRS CAUSING FOCAL LYSIS OF THE ACHR-BEARING MEMBRANES. ANTI-ACHR ANTIBODIES IN MG SERA ARE HETEROGENEOUS. IDENTIFICATION OF THE ANTI-ACHR SPECIFICITIES AND CHARACTERIZATION OF THEIR PATHOGENIC ROLE IS IMPORTANT FOR THE UNDERSTANDING AND TREATMENT OF THE DISEASE. (SHORTENED)

Grantor dc:publisher

Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

Year dc:date

1991

Author dc:creator

• Σοφιανός, Δημήτρης

• Acetylcholine receptor
• ANTI-ACHR ANTIBODIES (ANTI ACHR ABS)
• ANTI-MIR ANTIBODIES (ANTI-MIR ABS)
• FAB OF MONOCLONAL ANTIBODIES (FAB-MABS)
• FAB ΤΜΗΜΑΤΑ ΜΟΝΟΚΛΩΝΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ (FAB-MABS)
• HUMAN CELLLINE TE671 (TE671)
• Main immunogenic region (MIR)
• Monoclonal antibodies
• Myasthenia gravis (MG)
• ΑNTI-MIR ΑΝΤΙΣΩΜΑΤΑ (ANTI-MIR ABS)
• ΑΝΘΡΩΠΙΝΗ ΚΥΤΤΑΡΙΚΗ ΣΕΙΡΑ ΤΕ671 (ΤΕ671)
• ΑΝΤΙ-ACHR ΑΝΤΙΣΩΜΑΤΑ (ANTI-ACHR ABS)
• Βαρειά μυασθένεια (MG)
• Κύρια ανοσογόνος περιοχή (MIR)
• Μονοκλωνικά αντισώματα
• ΥΠΟΔΟΧΕΑΣ ΤΗΣ ΑΚΕΤΥΛΟΧΟΛΙΝΗΣ (ACHR)
• Natural Sciences
• Biological Sciences
• Φυσικές Επιστήμες
• Βιολογία

Language dc:language

gre

Identifier

10.12681/eadd/1618

OAI identifier oai:identifier

oai:10442/1618