{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1618"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1618","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΜΕΛΕΤΗ ΤΗΣ ΒΑΡΕΙΑΣ ΜΥΑΣΘΕΝΕΙΑΣ ΚΑΙ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΑΚΕΤΥΛΟΧΟΛΙΝΗΣ ΜΕ ΤΗΝ ΒΟΗΘΕΙΑ ΜΟΝΟΚΛΩΝΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ","abstract":"MYASTHENIA GRAVIS (MG) IS A NEUROMUSCULAR DISORDER MANIFESTED BY WEAKNESS AND FATIGABILITY OF VOLUNTARY MUSCLES DUE MAINLY TO AUTOANTIBODY-MEDIATED LOSS OF ACETYLCHOLINE RECEPTOR (ACHR). ACHR IS A MEMBRANE GLYCOPROTEIN (M.W.-290,000) COMPOSED OF FIVE SUBUNITS IN THE MOLECULAR RATIO OF A2BΓΔ. ANTIBODY-MEDIATED ACHR LOSS IN MG IS CAUSED BY AT LEAST TWO MECHANISMS: (A) BIVALENT AND POLYVALENT ANTIBODIES CROSSLINK MEMBRANE-BOUND RECEPTORS RESULTING IN INCREASED RECEPTOR INTERNALIZATION AND DEGRADATION RATE (ANTIGENIC MODULATION). (B) COMPLEMENT BINDS TO THE ANTIBODIES WHICH ARE ATTACHED ON THE MEMBRANE ACHRS CAUSING FOCAL LYSIS OF THE ACHR-BEARING MEMBRANES. ANTI-ACHR ANTIBODIES IN MG SERA ARE HETEROGENEOUS. IDENTIFICATION OF THE ANTI-ACHR SPECIFICITIES AND CHARACTERIZATION OF THEIR PATHOGENIC ROLE IS IMPORTANT FOR THE UNDERSTANDING AND TREATMENT OF THE DISEASE. (SHORTENED)","abstract_html":"MYASTHENIA GRAVIS (MG) IS A NEUROMUSCULAR DISORDER MANIFESTED BY WEAKNESS AND FATIGABILITY OF VOLUNTARY MUSCLES DUE MAINLY TO AUTOANTIBODY-MEDIATED LOSS OF ACETYLCHOLINE RECEPTOR (ACHR). ACHR IS A MEMBRANE GLYCOPROTEIN (M.W.-290,000) COMPOSED OF FIVE SUBUNITS IN THE MOLECULAR RATIO OF A2BΓΔ. ANTIBODY-MEDIATED ACHR LOSS IN MG IS CAUSED BY AT LEAST TWO MECHANISMS: (A) BIVALENT AND POLYVALENT ANTIBODIES CROSSLINK MEMBRANE-BOUND RECEPTORS RESULTING IN INCREASED RECEPTOR INTERNALIZATION AND DEGRADATION RATE (ANTIGENIC MODULATION). (B) COMPLEMENT BINDS TO THE ANTIBODIES WHICH ARE ATTACHED ON THE MEMBRANE ACHRS CAUSING FOCAL LYSIS OF THE ACHR-BEARING MEMBRANES. ANTI-ACHR ANTIBODIES IN MG SERA ARE HETEROGENEOUS. IDENTIFICATION OF THE ANTI-ACHR SPECIFICITIES AND CHARACTERIZATION OF THEIR PATHOGENIC ROLE IS IMPORTANT FOR THE UNDERSTANDING AND TREATMENT OF THE DISEASE. (SHORTENED)","abstract_has_math":false,"creators":["Σοφιανός, Δημήτρης"],"institution":"Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1991,"date_issued":"1991","date_published":"1991","updated_at":"2026-07-24T02:25:02Z","subjects":["Acetylcholine receptor","ANTI-ACHR ANTIBODIES (ANTI ACHR ABS)","ANTI-MIR ANTIBODIES (ANTI-MIR ABS)","FAB OF MONOCLONAL ANTIBODIES (FAB-MABS)","FAB ΤΜΗΜΑΤΑ ΜΟΝΟΚΛΩΝΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ (FAB-MABS)","HUMAN CELLLINE TE671 (TE671)","Main immunogenic region (MIR)","Monoclonal antibodies","Myasthenia gravis (MG)","ΑNTI-MIR ΑΝΤΙΣΩΜΑΤΑ (ANTI-MIR ABS)","ΑΝΘΡΩΠΙΝΗ ΚΥΤΤΑΡΙΚΗ ΣΕΙΡΑ ΤΕ671 (ΤΕ671)","ΑΝΤΙ-ACHR ΑΝΤΙΣΩΜΑΤΑ (ANTI-ACHR ABS)","Βαρειά μυασθένεια (MG)","Κύρια ανοσογόνος περιοχή (MIR)","Μονοκλωνικά αντισώματα","ΥΠΟΔΟΧΕΑΣ ΤΗΣ ΑΚΕΤΥΛΟΧΟΛΙΝΗΣ (ACHR)","Natural Sciences","Biological Sciences","Φυσικές Επιστήμες","Βιολογία"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1618"],"render_values":[{"text":"10.12681/eadd/1618","href":"https://doi.org/10.12681/eadd/1618","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1618","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Σοφιανός, Δημήτρης"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1991"]},{"key":"dc:publisher","label":"Institution","values":["Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)","National and Kapodistrian University of Athens"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Acetylcholine receptor","ANTI-ACHR ANTIBODIES (ANTI ACHR ABS)","ANTI-MIR ANTIBODIES (ANTI-MIR ABS)","FAB OF MONOCLONAL ANTIBODIES (FAB-MABS)","FAB ΤΜΗΜΑΤΑ ΜΟΝΟΚΛΩΝΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ (FAB-MABS)","HUMAN CELLLINE TE671 (TE671)","Main immunogenic region (MIR)","Monoclonal antibodies","Myasthenia gravis (MG)","ΑNTI-MIR ΑΝΤΙΣΩΜΑΤΑ (ANTI-MIR ABS)","ΑΝΘΡΩΠΙΝΗ ΚΥΤΤΑΡΙΚΗ ΣΕΙΡΑ ΤΕ671 (ΤΕ671)","ΑΝΤΙ-ACHR ΑΝΤΙΣΩΜΑΤΑ (ANTI-ACHR ABS)","Βαρειά μυασθένεια (MG)","Κύρια ανοσογόνος περιοχή (MIR)","Μονοκλωνικά αντισώματα","ΥΠΟΔΟΧΕΑΣ ΤΗΣ ΑΚΕΤΥΛΟΧΟΛΙΝΗΣ (ACHR)","Natural Sciences","Biological Sciences","Φυσικές Επιστήμες","Βιολογία"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1618","http://hdl.handle.net/10442/hedi/1618"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["MYASTHENIA GRAVIS (MG) IS A NEUROMUSCULAR DISORDER MANIFESTED BY WEAKNESS AND FATIGABILITY OF VOLUNTARY MUSCLES DUE MAINLY TO AUTOANTIBODY-MEDIATED LOSS OF ACETYLCHOLINE RECEPTOR (ACHR). ACHR IS A MEMBRANE GLYCOPROTEIN (M.W.-290,000) COMPOSED OF FIVE SUBUNITS IN THE MOLECULAR RATIO OF A2BΓΔ. ANTIBODY-MEDIATED ACHR LOSS IN MG IS CAUSED BY AT LEAST TWO MECHANISMS: (A) BIVALENT AND POLYVALENT ANTIBODIES CROSSLINK MEMBRANE-BOUND RECEPTORS RESULTING IN INCREASED RECEPTOR INTERNALIZATION AND DEGRADATION RATE (ANTIGENIC MODULATION). (B) COMPLEMENT BINDS TO THE ANTIBODIES WHICH ARE ATTACHED ON THE MEMBRANE ACHRS CAUSING FOCAL LYSIS OF THE ACHR-BEARING MEMBRANES. ANTI-ACHR ANTIBODIES IN MG SERA ARE HETEROGENEOUS. IDENTIFICATION OF THE ANTI-ACHR SPECIFICITIES AND CHARACTERIZATION OF THEIR PATHOGENIC ROLE IS IMPORTANT FOR THE UNDERSTANDING AND TREATMENT OF THE DISEASE. (SHORTENED)","Η ΒΑΡΕΙΑ ΜΥΑΣΘΕΝΕΙΑ (MG) ΕΙΝΑΙ ΜΙΑ ΝΕΥΡΟΜΥΙΚΗ ΠΑΘΗΣΗ Η ΟΠΟΙΑ ΠΡΟΚΑΛΕΙΤΑΙ ΑΠΟ ΑΥΤΟΑΝΤΙΣΩΜΑΤΑ ΠΟΥ ΕΛΑΤΤΩΝΟΥΝ ΤΟΝ ΑΡΙΘΜΟ ΤΩΝ ΝΙΚΟΤΙΝΙΚΩΝ ΥΠΟΔΟΧΕΩΝ ΤΗΣ ΑΚΕΤΥΛΟΧΟΛΙΝΗΣ (ACHR). Ο ACHR ΕΙΝΑΙ ΕΝΑ ΓΛΥΚΟΠΡΩΤΕΙΝΙΚΟ ΜΑΚΡΟΜΟΡΙΟ ΤΗΣ ΜΕΤΑΣΥΝΑΠΤΙΚΗΣ ΜΕΜΒΡΑΝΗΣ ΠΟΥ ΑΠΑΡΤΙΖΕΤΑΙ ΑΠΟ 5 ΥΠΟΜΟΝΑΔΕΣ ΜΕ ΣΤΟΙΧΕΙΟΜΕΤΡΙΑ Α2ΒΓΔ ΚΑΙ ΜΟΡΙΑΚΟ ΒΑΡΟΣ ΠΕΡΙΠΟΥ 290000. ΤΑ ΑΥΤΟΑΝΤΙΣΩΜΑΤΑ ΕΛΑΤΤΩΝΟΥΝ ΤΟΥΣ ACHR: (Α) ΜΕ ΤΗΝ ΔΙΑΣΥΝΔΕΣΗ ΤΩΝ ΓΕΙΤΟΝΙΚΩΝ ACHR ΑΠΟ ΤΑ ΔΙΔΥΝΑΜΑ 'Η ΠΟΛΥΔΥΝΑΜΑ ΑΝΤΙΣΩΜΑΤΑ (ΑΝΤΙΓΟΝΙΚΗ ΤΡΟΠΟΠΟΙΗΣΗ). (Β) ΜΕ ΤΗ ΔΡΑΣΗ ΤΟΥ ΣΥΜΠΛΗΡΩΜΑΤΟΣ ΤΟ ΟΠΟΙΟ ΠΡΟΣΔΕΝΕΤΑΙ ΣΤΑ ΑΝΤΙΣΩΜΑΤΑΠΟΥ ΕΧΟΥΝ ΗΔΗ ΠΡΟΣΔΕΘΕΙ ΣΤΟΥΣ ACHR ΚΑΤΑΣΤΡΕΦΟΝΤΑΣ ΣΤΗ ΣΥΝΕΧΕΙΑ ΤΗ ΜΕΤΑΣΥΝΑΠΤΙΚΗ ΜΕΜΒΡΑΝΗ. ΤΑ ANTI-ACHR ΑΝΤΙΣΩΜΑΤΑ ΣΤΟΥΣ ΟΡΟΥΣ ΤΩΝ ΜΥΑΣΘΕΝΩΝ ΠΑΡΟΥΣΙΑΖΟΥΝ ΕΤΕΡΟΓΕΝΕΙΑ. ΕΧΕΙ ΒΡΕΘΕΙ ΟΤΙ ΤΑ ΔΥΟ ΤΡΙΤΑ ΑΠΟ ΑΥΤΑ ΠΡΟΣΔΕΝΟΝΤΑΙ ΣΤΗΝ ΚΥΡΙΑ ΑΝΟΣΟΓΟΝΟ ΠΕΡΙΟΧΗ (MIR) ΤΟΥ ACHR Η ΟΠΟΙΑ ΕΝΤΟΠΙΖΕΤΑΙ ΣΤΗΝ Α-ΥΠΟΜΟΝΑΔΑ ΤΟΥ. Η ΠΑΘΟΓΟΝΙΚΗΔΡΑΣΤΙΚΟΤΗΤΑ ΤΟΣΟ ΤΩΝ ΑΝΤΙ-MIR ΟΣΟ ΚΑΙ ΤΩΝ ΑΝΤΙΣΩΜΑΤΩΝ ΕΝΑΝΤΙ ΑΛΛΩΝ ΠΕΡΙΟΧΩΝ ΔΕΝ ΕΙΝΑΙ ΓΝΩΣΤΗ. (ΠΕΡΙΚΟΠΗ)"]},{"key":"dc:title","label":"Title","values":["ΜΕΛΕΤΗ ΤΗΣ ΒΑΡΕΙΑΣ ΜΥΑΣΘΕΝΕΙΑΣ ΚΑΙ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΑΚΕΤΥΛΟΧΟΛΙΝΗΣ ΜΕ ΤΗΝ ΒΟΗΘΕΙΑ ΜΟΝΟΚΛΩΝΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ","STUDY OF MYASTHENIA GRAVIS AND ACETYLCHOLINE RECEPTOR BY THE USE OF MONOCLONAL ANTIBODIES"]}]}],"canonical_facts":{"dc:creator":["Σοφιανός, Δημήτρης"],"dc:date":["1991"],"dc:description":["MYASTHENIA GRAVIS (MG) IS A NEUROMUSCULAR DISORDER MANIFESTED BY WEAKNESS AND FATIGABILITY OF VOLUNTARY MUSCLES DUE MAINLY TO AUTOANTIBODY-MEDIATED LOSS OF ACETYLCHOLINE RECEPTOR (ACHR). ACHR IS A MEMBRANE GLYCOPROTEIN (M.W.-290,000) COMPOSED OF FIVE SUBUNITS IN THE MOLECULAR RATIO OF A2BΓΔ. ANTIBODY-MEDIATED ACHR LOSS IN MG IS CAUSED BY AT LEAST TWO MECHANISMS: (A) BIVALENT AND POLYVALENT ANTIBODIES CROSSLINK MEMBRANE-BOUND RECEPTORS RESULTING IN INCREASED RECEPTOR INTERNALIZATION AND DEGRADATION RATE (ANTIGENIC MODULATION). (B) COMPLEMENT BINDS TO THE ANTIBODIES WHICH ARE ATTACHED ON THE MEMBRANE ACHRS CAUSING FOCAL LYSIS OF THE ACHR-BEARING MEMBRANES. ANTI-ACHR ANTIBODIES IN MG SERA ARE HETEROGENEOUS. IDENTIFICATION OF THE ANTI-ACHR SPECIFICITIES AND CHARACTERIZATION OF THEIR PATHOGENIC ROLE IS IMPORTANT FOR THE UNDERSTANDING AND TREATMENT OF THE DISEASE. (SHORTENED)","Η ΒΑΡΕΙΑ ΜΥΑΣΘΕΝΕΙΑ (MG) ΕΙΝΑΙ ΜΙΑ ΝΕΥΡΟΜΥΙΚΗ ΠΑΘΗΣΗ Η ΟΠΟΙΑ ΠΡΟΚΑΛΕΙΤΑΙ ΑΠΟ ΑΥΤΟΑΝΤΙΣΩΜΑΤΑ ΠΟΥ ΕΛΑΤΤΩΝΟΥΝ ΤΟΝ ΑΡΙΘΜΟ ΤΩΝ ΝΙΚΟΤΙΝΙΚΩΝ ΥΠΟΔΟΧΕΩΝ ΤΗΣ ΑΚΕΤΥΛΟΧΟΛΙΝΗΣ (ACHR). Ο ACHR ΕΙΝΑΙ ΕΝΑ ΓΛΥΚΟΠΡΩΤΕΙΝΙΚΟ ΜΑΚΡΟΜΟΡΙΟ ΤΗΣ ΜΕΤΑΣΥΝΑΠΤΙΚΗΣ ΜΕΜΒΡΑΝΗΣ ΠΟΥ ΑΠΑΡΤΙΖΕΤΑΙ ΑΠΟ 5 ΥΠΟΜΟΝΑΔΕΣ ΜΕ ΣΤΟΙΧΕΙΟΜΕΤΡΙΑ Α2ΒΓΔ ΚΑΙ ΜΟΡΙΑΚΟ ΒΑΡΟΣ ΠΕΡΙΠΟΥ 290000. ΤΑ ΑΥΤΟΑΝΤΙΣΩΜΑΤΑ ΕΛΑΤΤΩΝΟΥΝ ΤΟΥΣ ACHR: (Α) ΜΕ ΤΗΝ ΔΙΑΣΥΝΔΕΣΗ ΤΩΝ ΓΕΙΤΟΝΙΚΩΝ ACHR ΑΠΟ ΤΑ ΔΙΔΥΝΑΜΑ 'Η ΠΟΛΥΔΥΝΑΜΑ ΑΝΤΙΣΩΜΑΤΑ (ΑΝΤΙΓΟΝΙΚΗ ΤΡΟΠΟΠΟΙΗΣΗ). (Β) ΜΕ ΤΗ ΔΡΑΣΗ ΤΟΥ ΣΥΜΠΛΗΡΩΜΑΤΟΣ ΤΟ ΟΠΟΙΟ ΠΡΟΣΔΕΝΕΤΑΙ ΣΤΑ ΑΝΤΙΣΩΜΑΤΑΠΟΥ ΕΧΟΥΝ ΗΔΗ ΠΡΟΣΔΕΘΕΙ ΣΤΟΥΣ ACHR ΚΑΤΑΣΤΡΕΦΟΝΤΑΣ ΣΤΗ ΣΥΝΕΧΕΙΑ ΤΗ ΜΕΤΑΣΥΝΑΠΤΙΚΗ ΜΕΜΒΡΑΝΗ. ΤΑ ANTI-ACHR ΑΝΤΙΣΩΜΑΤΑ ΣΤΟΥΣ ΟΡΟΥΣ ΤΩΝ ΜΥΑΣΘΕΝΩΝ ΠΑΡΟΥΣΙΑΖΟΥΝ ΕΤΕΡΟΓΕΝΕΙΑ. ΕΧΕΙ ΒΡΕΘΕΙ ΟΤΙ ΤΑ ΔΥΟ ΤΡΙΤΑ ΑΠΟ ΑΥΤΑ ΠΡΟΣΔΕΝΟΝΤΑΙ ΣΤΗΝ ΚΥΡΙΑ ΑΝΟΣΟΓΟΝΟ ΠΕΡΙΟΧΗ (MIR) ΤΟΥ ACHR Η ΟΠΟΙΑ ΕΝΤΟΠΙΖΕΤΑΙ ΣΤΗΝ Α-ΥΠΟΜΟΝΑΔΑ ΤΟΥ. Η ΠΑΘΟΓΟΝΙΚΗΔΡΑΣΤΙΚΟΤΗΤΑ ΤΟΣΟ ΤΩΝ ΑΝΤΙ-MIR ΟΣΟ ΚΑΙ ΤΩΝ ΑΝΤΙΣΩΜΑΤΩΝ ΕΝΑΝΤΙ ΑΛΛΩΝ ΠΕΡΙΟΧΩΝ ΔΕΝ ΕΙΝΑΙ ΓΝΩΣΤΗ. (ΠΕΡΙΚΟΠΗ)"],"dc:identifier":["10.12681/eadd/1618","http://hdl.handle.net/10442/hedi/1618"],"dc:language":["gre"],"dc:publisher":["Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)","National and Kapodistrian University of Athens"],"dc:subject":["Acetylcholine receptor","ANTI-ACHR ANTIBODIES (ANTI ACHR ABS)","ANTI-MIR ANTIBODIES (ANTI-MIR ABS)","FAB OF MONOCLONAL ANTIBODIES (FAB-MABS)","FAB ΤΜΗΜΑΤΑ ΜΟΝΟΚΛΩΝΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ (FAB-MABS)","HUMAN CELLLINE TE671 (TE671)","Main immunogenic region (MIR)","Monoclonal antibodies","Myasthenia gravis (MG)","ΑNTI-MIR ΑΝΤΙΣΩΜΑΤΑ (ANTI-MIR ABS)","ΑΝΘΡΩΠΙΝΗ ΚΥΤΤΑΡΙΚΗ ΣΕΙΡΑ ΤΕ671 (ΤΕ671)","ΑΝΤΙ-ACHR ΑΝΤΙΣΩΜΑΤΑ (ANTI-ACHR ABS)","Βαρειά μυασθένεια (MG)","Κύρια ανοσογόνος περιοχή (MIR)","Μονοκλωνικά αντισώματα","ΥΠΟΔΟΧΕΑΣ ΤΗΣ ΑΚΕΤΥΛΟΧΟΛΙΝΗΣ (ACHR)","Natural Sciences","Biological Sciences","Φυσικές Επιστήμες","Βιολογία"],"dc:title":["ΜΕΛΕΤΗ ΤΗΣ ΒΑΡΕΙΑΣ ΜΥΑΣΘΕΝΕΙΑΣ ΚΑΙ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΑΚΕΤΥΛΟΧΟΛΙΝΗΣ ΜΕ ΤΗΝ ΒΟΗΘΕΙΑ ΜΟΝΟΚΛΩΝΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ","STUDY OF MYASTHENIA GRAVIS AND ACETYLCHOLINE RECEPTOR BY THE USE OF MONOCLONAL ANTIBODIES"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:02Z"}