Ανάλυση λεμφοκυτταρικών υποπληθυσμών στην χρόνια λεμφογενή λευχαιμία με χρήση μονοκλωνικών αντισωμάτων: Προγνωστική σημασία ανοσολογικών παραμέτρων

We determined immune function parameters in 41 newly diagnosed patients with chronic lymphocytic leukaemia (CLL) and correlated these findings with the clinical data and the subsequent course of the disease. The ratio of helper to supressor T cells (CD4/CD8), the proportion of circulating natural killer (nk) cells and the nk activity were significantly low in clinical stage B and C patients. Patients with low H/S ratio (<1.1), irrespective of clinical stage, had a mean amount of gammaglobulins of 0.69±0.08 g/dl (x±SEM), in comparison with 1.03±0.09 which was the mean in patients with a H/S ratio of >1.1 (p<0.01). A small group of 7 patients with pronounced lymphadenopathy and marginary increased blood lymphocytes (4.5-10x10⁹/1), all of them with heavy infiltration of bone marrow, has been included in a seperate category (lymphoma-like disease) and found to have a mean percentage of CD16+ cells of 15.35±3.08, vs 6.36±1.15 in all other B and C stage patients with typical CLL (p<0.01). Among patients presenting with advanced disease, those who subsequently had a more severe course, characterised mainly by frequent respiratory infections, were found to have a presentation a significantly lower CD4/CD8 ratio (x±SEM: 0.95±0.09, vs 1.28±0.14), a very low proportion of NK cells (4.78±0.85, vs 11.75±2.1%) and degreased amount of γ-globulins (0.66±0.08, vs 0.97±0.09 g/dl), gd in comparison with patients with a much milder later course. It is possible therefore to distinguish at presentation those patients more prone to infections by using these parameters and, accordingly, monitoring them for prevention and prompt treatment. These simple parameters of immune function seem to have prognostic value for patients with CLL.

Grantor dc:publisher

University of Patras

Year dc:date

1990

Authors dc:creator

• Apostolopoulos, Apostolos
• Αποστολόπουλος, Απόστολος

• Κυτταροτοξικότητα των ΝΚ κυττάρων
• Λεμφοκυτταρικοί υποπληθυσμοί
• Μονοκλωνικά αντισώματα
• Χρόνια λεμφογενής λευχαιμία
• Leukemia, Chronic lymphocytic
• Lymphocytic subpopulations
• Monoclonal antibodies
• NK-activity
• Ιατρική και Επιστήμες Υγείας
• Βασική Ιατρική
• Κλινική Ιατρική
• Medical and Health Sciences
• Basic Medicine
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/1493

OAI identifier oai:identifier

oai:10442/1493