{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1493"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1493","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"Ανάλυση λεμφοκυτταρικών υποπληθυσμών στην χρόνια λεμφογενή λευχαιμία με χρήση μονοκλωνικών αντισωμάτων: Προγνωστική σημασία ανοσολογικών παραμέτρων","abstract":"We determined immune function parameters in 41 newly diagnosed patients with chronic lymphocytic leukaemia (CLL) and correlated these findings with the clinical data and the subsequent course of the disease. The ratio of helper to supressor T cells (CD4/CD8), the proportion of circulating natural killer (nk) cells and the nk activity were significantly low in clinical stage B and C patients. Patients with low H/S ratio (<1.1), irrespective of clinical stage, had a mean amount of gammaglobulins of 0.69±0.08 g/dl (x±SEM), in comparison with 1.03±0.09 which was the mean in patients with a H/S ratio of >1.1 (p<0.01). A small group of 7 patients with pronounced lymphadenopathy and marginary increased blood lymphocytes (4.5-10x10⁹/1), all of them with heavy infiltration of bone marrow, has been included in a seperate category (lymphoma-like disease) and found to have a mean percentage of CD16+ cells of 15.35±3.08, vs 6.36±1.15 in all other B and C stage patients with typical CLL (p<0.01). Among patients presenting with advanced disease, those who subsequently had a more severe course, characterised mainly by frequent respiratory infections, were found to have a presentation a significantly lower CD4/CD8 ratio (x±SEM: 0.95±0.09, vs 1.28±0.14), a very low proportion of NK cells (4.78±0.85, vs 11.75±2.1%) and degreased amount of γ-globulins (0.66±0.08, vs 0.97±0.09 g/dl), gd in comparison with patients with a much milder later course. It is possible therefore to distinguish at presentation those patients more prone to infections by using these parameters and, accordingly, monitoring them for prevention and prompt treatment. These simple parameters of immune function seem to have prognostic value for patients with CLL.","abstract_html":"We determined immune function parameters in 41 newly diagnosed patients with chronic lymphocytic leukaemia (CLL) and correlated these findings with the clinical data and the subsequent course of the disease. The ratio of helper to supressor T cells (CD4/CD8), the proportion of circulating natural killer (nk) cells and the nk activity were significantly low in clinical stage B and C patients. Patients with low H/S ratio (&lt;1.1), irrespective of clinical stage, had a mean amount of gammaglobulins of 0.69±0.08 g/dl (x±SEM), in comparison with 1.03±0.09 which was the mean in patients with a H/S ratio of &gt;1.1 (p&lt;0.01). A small group of 7 patients with pronounced lymphadenopathy and marginary increased blood lymphocytes (4.5-10x10⁹/1), all of them with heavy infiltration of bone marrow, has been included in a seperate category (lymphoma-like disease) and found to have a mean percentage of CD16+ cells of 15.35±3.08, vs 6.36±1.15 in all other B and C stage patients with typical CLL (p&lt;0.01). Among patients presenting with advanced disease, those who subsequently had a more severe course, characterised mainly by frequent respiratory infections, were found to have a presentation a significantly lower CD4/CD8 ratio (x±SEM: 0.95±0.09, vs 1.28±0.14), a very low proportion of NK cells (4.78±0.85, vs 11.75±2.1%) and degreased amount of γ-globulins (0.66±0.08, vs 0.97±0.09 g/dl), gd in comparison with patients with a much milder later course. It is possible therefore to distinguish at presentation those patients more prone to infections by using these parameters and, accordingly, monitoring them for prevention and prompt treatment. These simple parameters of immune function seem to have prognostic value for patients with CLL.","abstract_has_math":false,"creators":["Apostolopoulos, Apostolos","Αποστολόπουλος, Απόστολος"],"institution":"University of Patras","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1990,"date_issued":"1990","date_published":"1990","updated_at":"2026-07-24T02:24:56Z","subjects":["Κυτταροτοξικότητα των ΝΚ κυττάρων","Λεμφοκυτταρικοί υποπληθυσμοί","Μονοκλωνικά αντισώματα","Χρόνια λεμφογενής λευχαιμία","Leukemia, Chronic lymphocytic","Lymphocytic subpopulations","Monoclonal antibodies","NK-activity","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Κλινική Ιατρική","Medical and Health Sciences","Basic Medicine","Clinical Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1493"],"render_values":[{"text":"10.12681/eadd/1493","href":"https://doi.org/10.12681/eadd/1493","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1493","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Apostolopoulos, Apostolos","Αποστολόπουλος, Απόστολος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1990"]},{"key":"dc:publisher","label":"Institution","values":["University of Patras","Πανεπιστήμιο Πατρών"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Κυτταροτοξικότητα των ΝΚ κυττάρων","Λεμφοκυτταρικοί υποπληθυσμοί","Μονοκλωνικά αντισώματα","Χρόνια λεμφογενής λευχαιμία","Leukemia, Chronic lymphocytic","Lymphocytic subpopulations","Monoclonal antibodies","NK-activity","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Κλινική Ιατρική","Medical and Health Sciences","Basic Medicine","Clinical Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1493","http://hdl.handle.net/10442/hedi/1493"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["We determined immune function parameters in 41 newly diagnosed patients with chronic lymphocytic leukaemia (CLL) and correlated these findings with the clinical data and the subsequent course of the disease. The ratio of helper to supressor T cells (CD4/CD8), the proportion of circulating natural killer (nk) cells and the nk activity were significantly low in clinical stage B and C patients. Patients with low H/S ratio (<1.1), irrespective of clinical stage, had a mean amount of gammaglobulins of 0.69±0.08 g/dl (x±SEM), in comparison with 1.03±0.09 which was the mean in patients with a H/S ratio of >1.1 (p<0.01). A small group of 7 patients with pronounced lymphadenopathy and marginary increased blood lymphocytes (4.5-10x10⁹/1), all of them with heavy infiltration of bone marrow, has been included in a seperate category (lymphoma-like disease) and found to have a mean percentage of CD16+ cells of 15.35±3.08, vs 6.36±1.15 in all other B and C stage patients with typical CLL (p<0.01). Among patients presenting with advanced disease, those who subsequently had a more severe course, characterised mainly by frequent respiratory infections, were found to have a presentation a significantly lower CD4/CD8 ratio (x±SEM: 0.95±0.09, vs 1.28±0.14), a very low proportion of NK cells (4.78±0.85, vs 11.75±2.1%) and degreased amount of γ-globulins (0.66±0.08, vs 0.97±0.09 g/dl), gd in comparison with patients with a much milder later course. It is possible therefore to distinguish at presentation those patients more prone to infections by using these parameters and, accordingly, monitoring them for prevention and prompt treatment. These simple parameters of immune function seem to have prognostic value for patients with CLL.","Έγινε μελέτη ανοσολογικών παραμέτρων σε 41 ασθενείς με Β-Χ.Λ.Λ., συσχέτιση των ευρημάτων με την κλινική πορεία της νόσου και εκτίμηση της προγνωστικής σημασίας τους. Ιδιαίτερα μελετήθηκαν οι λεμφοκυτταρικοί υποπληθυσμοί με χρήση μονοκλωνικών αντισωμάτων, η άμεση κυτταρολυτική δραστηριότητα (NKa) των ΝΚ κυττάρων έναντι της κυτταρικής σειράς Κ562 και οι ανοσοσφαιρίνες επιφανείας με χρήση αντί ορών. Ο λόγος βοηθητικών προς κατασταλτικά Τ- λεμφοκύτταρα (CD4/CD8), το ποσοστό των κυκλοφορούντων ΝΚ κυττάρων (CD16+) και η άμεση κυτταρολυτική δραστηριότητα (NKa) των NK κυττάρων ήταν σημαντικά ελαττωμένα σε ασθενείς σταδίου Β και C. Ασθενείς με χαμηλό λόγο CD4/CD8 (<1.1) (x ±Sem: 0.69 ±0.08, vs 1.03±0.08 g/dl, p<0. 01). Μιά μικρή ομάδα ασθενών με εκσεσημασμένη λεμφαδενοπάθεια, οριακή λεμφοκυττάρωση (4.5-10x10⁹/1) και σημαντική διήθηση του μυελού κατατάχθηκε χωριστά ως νόσος τύπου λεμφώματος. Ιδιαίτερο χαρακτηριστικό αυτών των ασθενών ήταν το υψηλό ποσοστό CD16+ κυττάρων σε σχέση με τους υπόλοιπους ασθενείς σταδίου Β και C, (x±sem: 15.35±3.08, vs 6.36±1.15%, p<0.01). Διαπιστώθηκε ότι ασθενείς με σοβαρή κλινική πορεία και ιδιαίτερο χαρακτηριστικό την εκδήλωση συχνών λοιμώξεων του αναπνευστικού συστήματος κατά τον αρχικό έλεγχο είχαν μεγάλη αναστροφή του λόγου CD4/CD8 (x±sem: 0.95±0.09, vs 1.28±0.14), χαμηλό ποσοστό ΝΚ κυττάρων (4.78±0.85, vs 11.75±2.1%) και σημαντική υπογαμμασφαιριναιμία (0.66±0.08, vs 0.97±0.09 g/dl) σε σχέση με τους υπόλοιπους ασθενείς σταδίου B και C. Οι τρεις ανωτέρω απλοί ανοσολογικοί παράμετροι φαίνεται ότι έχουν προγνωστική αξία για τους ασθενείς με Χ.Λ.Λ. και δίνουν την δυνατότητα κατά την διάγνωση διάκρισης ασθενών με αυξημένο κίνδυνο για σοβαρή κλινική εξέλιξη με συχνές λοιμώξεις του αναπνευστικού συστήματος."]},{"key":"dc:title","label":"Title","values":["Ανάλυση λεμφοκυτταρικών υποπληθυσμών στην χρόνια λεμφογενή λευχαιμία με χρήση μονοκλωνικών αντισωμάτων: Προγνωστική σημασία ανοσολογικών παραμέτρων","Lymphocyte subpopulations in B-chronic lymphocytic leukemia by using monoclonal antibodies"]}]}],"canonical_facts":{"dc:creator":["Apostolopoulos, Apostolos","Αποστολόπουλος, Απόστολος"],"dc:date":["1990"],"dc:description":["We determined immune function parameters in 41 newly diagnosed patients with chronic lymphocytic leukaemia (CLL) and correlated these findings with the clinical data and the subsequent course of the disease. The ratio of helper to supressor T cells (CD4/CD8), the proportion of circulating natural killer (nk) cells and the nk activity were significantly low in clinical stage B and C patients. Patients with low H/S ratio (<1.1), irrespective of clinical stage, had a mean amount of gammaglobulins of 0.69±0.08 g/dl (x±SEM), in comparison with 1.03±0.09 which was the mean in patients with a H/S ratio of >1.1 (p<0.01). A small group of 7 patients with pronounced lymphadenopathy and marginary increased blood lymphocytes (4.5-10x10⁹/1), all of them with heavy infiltration of bone marrow, has been included in a seperate category (lymphoma-like disease) and found to have a mean percentage of CD16+ cells of 15.35±3.08, vs 6.36±1.15 in all other B and C stage patients with typical CLL (p<0.01). Among patients presenting with advanced disease, those who subsequently had a more severe course, characterised mainly by frequent respiratory infections, were found to have a presentation a significantly lower CD4/CD8 ratio (x±SEM: 0.95±0.09, vs 1.28±0.14), a very low proportion of NK cells (4.78±0.85, vs 11.75±2.1%) and degreased amount of γ-globulins (0.66±0.08, vs 0.97±0.09 g/dl), gd in comparison with patients with a much milder later course. It is possible therefore to distinguish at presentation those patients more prone to infections by using these parameters and, accordingly, monitoring them for prevention and prompt treatment. These simple parameters of immune function seem to have prognostic value for patients with CLL.","Έγινε μελέτη ανοσολογικών παραμέτρων σε 41 ασθενείς με Β-Χ.Λ.Λ., συσχέτιση των ευρημάτων με την κλινική πορεία της νόσου και εκτίμηση της προγνωστικής σημασίας τους. Ιδιαίτερα μελετήθηκαν οι λεμφοκυτταρικοί υποπληθυσμοί με χρήση μονοκλωνικών αντισωμάτων, η άμεση κυτταρολυτική δραστηριότητα (NKa) των ΝΚ κυττάρων έναντι της κυτταρικής σειράς Κ562 και οι ανοσοσφαιρίνες επιφανείας με χρήση αντί ορών. Ο λόγος βοηθητικών προς κατασταλτικά Τ- λεμφοκύτταρα (CD4/CD8), το ποσοστό των κυκλοφορούντων ΝΚ κυττάρων (CD16+) και η άμεση κυτταρολυτική δραστηριότητα (NKa) των NK κυττάρων ήταν σημαντικά ελαττωμένα σε ασθενείς σταδίου Β και C. Ασθενείς με χαμηλό λόγο CD4/CD8 (<1.1) (x ±Sem: 0.69 ±0.08, vs 1.03±0.08 g/dl, p<0. 01). Μιά μικρή ομάδα ασθενών με εκσεσημασμένη λεμφαδενοπάθεια, οριακή λεμφοκυττάρωση (4.5-10x10⁹/1) και σημαντική διήθηση του μυελού κατατάχθηκε χωριστά ως νόσος τύπου λεμφώματος. Ιδιαίτερο χαρακτηριστικό αυτών των ασθενών ήταν το υψηλό ποσοστό CD16+ κυττάρων σε σχέση με τους υπόλοιπους ασθενείς σταδίου Β και C, (x±sem: 15.35±3.08, vs 6.36±1.15%, p<0.01). Διαπιστώθηκε ότι ασθενείς με σοβαρή κλινική πορεία και ιδιαίτερο χαρακτηριστικό την εκδήλωση συχνών λοιμώξεων του αναπνευστικού συστήματος κατά τον αρχικό έλεγχο είχαν μεγάλη αναστροφή του λόγου CD4/CD8 (x±sem: 0.95±0.09, vs 1.28±0.14), χαμηλό ποσοστό ΝΚ κυττάρων (4.78±0.85, vs 11.75±2.1%) και σημαντική υπογαμμασφαιριναιμία (0.66±0.08, vs 0.97±0.09 g/dl) σε σχέση με τους υπόλοιπους ασθενείς σταδίου B και C. Οι τρεις ανωτέρω απλοί ανοσολογικοί παράμετροι φαίνεται ότι έχουν προγνωστική αξία για τους ασθενείς με Χ.Λ.Λ. και δίνουν την δυνατότητα κατά την διάγνωση διάκρισης ασθενών με αυξημένο κίνδυνο για σοβαρή κλινική εξέλιξη με συχνές λοιμώξεις του αναπνευστικού συστήματος."],"dc:identifier":["10.12681/eadd/1493","http://hdl.handle.net/10442/hedi/1493"],"dc:language":["gre"],"dc:publisher":["University of Patras","Πανεπιστήμιο Πατρών"],"dc:subject":["Κυτταροτοξικότητα των ΝΚ κυττάρων","Λεμφοκυτταρικοί υποπληθυσμοί","Μονοκλωνικά αντισώματα","Χρόνια λεμφογενής λευχαιμία","Leukemia, Chronic lymphocytic","Lymphocytic subpopulations","Monoclonal antibodies","NK-activity","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Κλινική Ιατρική","Medical and Health Sciences","Basic Medicine","Clinical Medicine"],"dc:title":["Ανάλυση λεμφοκυτταρικών υποπληθυσμών στην χρόνια λεμφογενή λευχαιμία με χρήση μονοκλωνικών αντισωμάτων: Προγνωστική σημασία ανοσολογικών παραμέτρων","Lymphocyte subpopulations in B-chronic lymphocytic leukemia by using monoclonal antibodies"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:24:56Z"}