Ανοσοϊστοχημική μελέτη της έκφρασης των οιστρογονικών υποδοχέων στους όγκους των ωοθηκών με μονοκλωνικά αντισώματα (με την μέθοδο αβιντίνης-βιοτίνης)

We studied immunohistochemically the estrogen receptor expression in paraffin sections of 71 neoplasms and 6 non-neoplasmic cysts of the ovaries, using the avidin-biotin-peroxidase complex (ABC) method and monoclonal anti-ER antibodies. The estrogen receptors (ER) were localized in 35% of cystadenomy in 67% of tumors of borderline malignancy and in 66% of carcinomas; also in 67% of sex cord-stromal tumors, in 29% of germ cell tumors and in 33% of metastatic tumors, while they were not detected at all in ovarian cysts. We conclude that ER-positive ovarian tumors, especially the richest in ER-content serous and undifferentiates carcinomas, are candidates for antiestrogen endocrine therapy, adjuvant to surgery and chemotherapy. Our method can detect ER in paraffin sections of ovarian tumors with precision, thus making possible both their retrospective examination and the simultaneous comparison of their histopathological features to their ER expression.

Grantor dc:publisher

University of Ioannina

Year dc:date

1990

Authors dc:creator

• Adamopoulos, Spyridon
• Αδαμόπουλος, Σπυρίδων

• Ανοσοϊστοχημεία
• Μονοκλωνικά αντισώματα
• Οιστρογόνοι υποδοχείς
• Ωοθηκικοί όγκοι
• Estrogen receptors
• Immunohistochemistry ( IHC)
• Monoclonal antibodies
• Ovarian tumors
• Ιατρική και Επιστήμες Υγείας
• Βασική Ιατρική
• Κλινική Ιατρική
• Medical and Health Sciences
• Basic Medicine
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/1402

OAI identifier oai:identifier

oai:10442/1402