ΣΥΝΘΕΣΗ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΜΕΛΕΤΗ ΤΩΝ ΠΑΡΑΓΩΓΩΝ ΤΟΥ 1,8-ΔΙΑΜΙΝΟ-3,6-ΔΙΘΕΙΑ- ΟΚΤΑΝΙΟΥ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99Μ

A SERIES OF MONO- AND DISUBSTITUTED 1,8-DIAMINE-3,6-DITHIA- OCTANE (I) DERIVATIVES WERE SYNTHESIZED, AS POSSIBLE LIGANDS OF REDUCED TC-99M. THE PRODUCTS WERE CHARACTERIZED BY ELEMENTAL ANALYSIS AND NMR SPECTROSCOPY. THE LIGANDS WERE LABELLED IN AQUEOUS MEDIA WITH TC-99M AFTER ITS REDUCTION WITH NABH4. THEN THE LABELLED COMPOUNDS WERE ANALYZED BY HPLC IN ONE OR MORE 99M TC-SPECIES. THESE WERE FURTHER STUDIED BY ELECTROPHORESIS (CHARGE, IN VITRO STABILITY) AND THEIR LIPOPHILICITY DETERMINED. THEY WERE FOUND TO BE IN STABLE, NEUTRAL IN BLOOD PH LIPOPHILIC 99M TC -COMPLEXES. MOST LIPOPHILIC COMPLEXES WERE ADMINISTERED IN WHITE MICE, IN ORDER TO STUDY THEIR BIODISTRIBUTION, WHICH WAS CHARACTERISTIC FOR EACH COMPLEX. SOME OF THE COMPLEXES EXHIBITED INTERESTING BIOLOGICAL PROPERTIES SUCH AS RETENTION IN BRAIN OR HEART TISSUE. IT IS CONCLUDED, THAT I DERIVATIVES, WHEN LABELLED WITH TC-99M, FORM COMPLEXES OF DIFFERENT STRUCTURE AND THUS EXHIBITING DIFFERENT PHYSICOCHEMICAL AND BIOLOGICAL BEHAVIOUR.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1989

Author dc:creator

• Μάινα, Θεοδοσία

• 1,8-ΔΙΑΜΙΝΟ-3,6-ΔΙΘΕΙΑ-ΟΚΤΑΝΙΟΥ ΠΑΡΑΓΩΓΑ
• Διαγνωστική
• ΡΑΔΙΟΦΑΡΜΑΚΕΥΤΙΚΗ ΤΕΧΝΟΛΟΓΙΑ
• ΥΠΟΚΑΤΑΣΤΑΤΕΣ NXS2 ΓΙΑ ΤΟ TC-99M
• ΧΗΛΙΚΕΣ ΕΝΩΣΕΙΣ ΤΟΥ TC-99M ΜΕ ΠΑΡΑΓΩΓΑ NXS2
• 1,8-DIAMINE-3,6-DITHIA-OCTANE DERIVATIVES
• Diagnosis
• MULTIDENTATE (NXS2) LICANDS FOR REDUCED TC-99M
• RADIOPHARMACEUTICAL TECHNOLOGY
• Ιατρική και Επιστήμες Υγείας
• Βασική Ιατρική
• Medical and Health Sciences
• Basic Medicine

Language dc:language

gre

Identifier

10.12681/eadd/1171

OAI identifier oai:identifier

oai:10442/1171