{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1171"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1171","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΣΥΝΘΕΣΗ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΜΕΛΕΤΗ ΤΩΝ ΠΑΡΑΓΩΓΩΝ ΤΟΥ 1,8-ΔΙΑΜΙΝΟ-3,6-ΔΙΘΕΙΑ- ΟΚΤΑΝΙΟΥ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99Μ","abstract":"A SERIES OF MONO- AND DISUBSTITUTED 1,8-DIAMINE-3,6-DITHIA- OCTANE (I) DERIVATIVES WERE SYNTHESIZED, AS POSSIBLE LIGANDS OF REDUCED TC-99M. THE PRODUCTS WERE CHARACTERIZED BY ELEMENTAL ANALYSIS AND NMR SPECTROSCOPY. THE LIGANDS WERE LABELLED IN AQUEOUS MEDIA WITH TC-99M AFTER ITS REDUCTION WITH NABH4. THEN THE LABELLED COMPOUNDS WERE ANALYZED BY HPLC IN ONE OR MORE 99M TC-SPECIES. THESE WERE FURTHER STUDIED BY ELECTROPHORESIS (CHARGE, IN VITRO STABILITY) AND THEIR LIPOPHILICITY DETERMINED. THEY WERE FOUND TO BE IN STABLE, NEUTRAL IN BLOOD PH LIPOPHILIC 99M TC -COMPLEXES. MOST LIPOPHILIC COMPLEXES WERE ADMINISTERED IN WHITE MICE, IN ORDER TO STUDY THEIR BIODISTRIBUTION, WHICH WAS CHARACTERISTIC FOR EACH COMPLEX. SOME OF THE COMPLEXES EXHIBITED INTERESTING BIOLOGICAL PROPERTIES SUCH AS RETENTION IN BRAIN OR HEART TISSUE. IT IS CONCLUDED, THAT I DERIVATIVES, WHEN LABELLED WITH TC-99M, FORM COMPLEXES OF DIFFERENT STRUCTURE AND THUS EXHIBITING DIFFERENT PHYSICOCHEMICAL AND BIOLOGICAL BEHAVIOUR.","abstract_html":"A SERIES OF MONO- AND DISUBSTITUTED 1,8-DIAMINE-3,6-DITHIA- OCTANE (I) DERIVATIVES WERE SYNTHESIZED, AS POSSIBLE LIGANDS OF REDUCED TC-99M. THE PRODUCTS WERE CHARACTERIZED BY ELEMENTAL ANALYSIS AND NMR SPECTROSCOPY. THE LIGANDS WERE LABELLED IN AQUEOUS MEDIA WITH TC-99M AFTER ITS REDUCTION WITH NABH4. THEN THE LABELLED COMPOUNDS WERE ANALYZED BY HPLC IN ONE OR MORE 99M TC-SPECIES. THESE WERE FURTHER STUDIED BY ELECTROPHORESIS (CHARGE, IN VITRO STABILITY) AND THEIR LIPOPHILICITY DETERMINED. THEY WERE FOUND TO BE IN STABLE, NEUTRAL IN BLOOD PH LIPOPHILIC 99M TC -COMPLEXES. MOST LIPOPHILIC COMPLEXES WERE ADMINISTERED IN WHITE MICE, IN ORDER TO STUDY THEIR BIODISTRIBUTION, WHICH WAS CHARACTERISTIC FOR EACH COMPLEX. SOME OF THE COMPLEXES EXHIBITED INTERESTING BIOLOGICAL PROPERTIES SUCH AS RETENTION IN BRAIN OR HEART TISSUE. IT IS CONCLUDED, THAT I DERIVATIVES, WHEN LABELLED WITH TC-99M, FORM COMPLEXES OF DIFFERENT STRUCTURE AND THUS EXHIBITING DIFFERENT PHYSICOCHEMICAL AND BIOLOGICAL BEHAVIOUR.","abstract_has_math":false,"creators":["Μάινα, Θεοδοσία"],"institution":"National and Kapodistrian University of Athens","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1989,"date_issued":"1989","date_published":"1989","updated_at":"2026-07-24T02:24:46Z","subjects":["1,8-ΔΙΑΜΙΝΟ-3,6-ΔΙΘΕΙΑ-ΟΚΤΑΝΙΟΥ ΠΑΡΑΓΩΓΑ","Διαγνωστική","ΡΑΔΙΟΦΑΡΜΑΚΕΥΤΙΚΗ ΤΕΧΝΟΛΟΓΙΑ","ΥΠΟΚΑΤΑΣΤΑΤΕΣ NXS2 ΓΙΑ ΤΟ TC-99M","ΧΗΛΙΚΕΣ ΕΝΩΣΕΙΣ ΤΟΥ TC-99M ΜΕ ΠΑΡΑΓΩΓΑ NXS2","1,8-DIAMINE-3,6-DITHIA-OCTANE DERIVATIVES","Diagnosis","MULTIDENTATE (NXS2) LICANDS FOR REDUCED TC-99M","RADIOPHARMACEUTICAL TECHNOLOGY","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1171"],"render_values":[{"text":"10.12681/eadd/1171","href":"https://doi.org/10.12681/eadd/1171","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1171","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Μάινα, Θεοδοσία"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1989"]},{"key":"dc:publisher","label":"Institution","values":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["1,8-ΔΙΑΜΙΝΟ-3,6-ΔΙΘΕΙΑ-ΟΚΤΑΝΙΟΥ ΠΑΡΑΓΩΓΑ","Διαγνωστική","ΡΑΔΙΟΦΑΡΜΑΚΕΥΤΙΚΗ ΤΕΧΝΟΛΟΓΙΑ","ΥΠΟΚΑΤΑΣΤΑΤΕΣ NXS2 ΓΙΑ ΤΟ TC-99M","ΧΗΛΙΚΕΣ ΕΝΩΣΕΙΣ ΤΟΥ TC-99M ΜΕ ΠΑΡΑΓΩΓΑ NXS2","1,8-DIAMINE-3,6-DITHIA-OCTANE DERIVATIVES","Diagnosis","MULTIDENTATE (NXS2) LICANDS FOR REDUCED TC-99M","RADIOPHARMACEUTICAL TECHNOLOGY","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1171","http://hdl.handle.net/10442/hedi/1171"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["A SERIES OF MONO- AND DISUBSTITUTED 1,8-DIAMINE-3,6-DITHIA- OCTANE (I) DERIVATIVES WERE SYNTHESIZED, AS POSSIBLE LIGANDS OF REDUCED TC-99M. THE PRODUCTS WERE CHARACTERIZED BY ELEMENTAL ANALYSIS AND NMR SPECTROSCOPY. THE LIGANDS WERE LABELLED IN AQUEOUS MEDIA WITH TC-99M AFTER ITS REDUCTION WITH NABH4. THEN THE LABELLED COMPOUNDS WERE ANALYZED BY HPLC IN ONE OR MORE 99M TC-SPECIES. THESE WERE FURTHER STUDIED BY ELECTROPHORESIS (CHARGE, IN VITRO STABILITY) AND THEIR LIPOPHILICITY DETERMINED. THEY WERE FOUND TO BE IN STABLE, NEUTRAL IN BLOOD PH LIPOPHILIC 99M TC -COMPLEXES. MOST LIPOPHILIC COMPLEXES WERE ADMINISTERED IN WHITE MICE, IN ORDER TO STUDY THEIR BIODISTRIBUTION, WHICH WAS CHARACTERISTIC FOR EACH COMPLEX. SOME OF THE COMPLEXES EXHIBITED INTERESTING BIOLOGICAL PROPERTIES SUCH AS RETENTION IN BRAIN OR HEART TISSUE. IT IS CONCLUDED, THAT I DERIVATIVES, WHEN LABELLED WITH TC-99M, FORM COMPLEXES OF DIFFERENT STRUCTURE AND THUS EXHIBITING DIFFERENT PHYSICOCHEMICAL AND BIOLOGICAL BEHAVIOUR.","ΕΓΙΝΕ Η ΣΥΝΘΕΣΗ ΣΕΙΡΑΣ ΜΟΝΟ- ΚΑΙ ΔΙΥΠΟΚΑΤΕΣΤΗΜΕΝΩΝ ΠΑΡΑΓΩΓΩΝ ΤΟΥ 1,8-ΔΙΑΜΙΝΟ-3,6-ΔΙΘΕΙΑ-ΟΚΤΑΝΙΟΥ (Ι) ΩΣ ΥΠΟΚΑΤΑΣΤΑΤΩΝ ΤΟΥ ΑΝΑΧΘΕΝΤΟΣ TC-99M. ΟΙ ΥΠΟΚΑΤΑΣΤΑΤΕΣ ΤΑΥΤΟΠΟΙΗΘΗΚΑΝ ΜΕ ΣΤΟΙΧΕΙΑΚΗ ΑΝΑΛΥΣΗ ΚΑΙ ΦΑΣΜΑΤΑ NMR. ΤΑ ΠΑΡΑΓΩΓΑ Ι ΕΠΙΣΗΜΑΝΘΗΚΑΝ ΑΚΟΛΟΥΘΩΣ ΣΕ ΥΔΑΤΙΚΟ ΠΕΡΙΒΑΛΛΟΝ ΜΕ TC-99M ΜΕΤΑ ΤΗΝ ΑΝΑΓΩΓΗ ΤΟΥΤΟΥ ΜΕ NABH2. ΣΤΗ ΣΥΝΕΧΕΙΑ ΤΑ ΡΑΔΙΟΣΗΜΑΣΜΕΝΑ ΠΡΟΙΟΝΤΑ ΔΙΑΧΩΡΙΣΤΗΚΑΝ ΜΕ HPLC ΣΕ ΕΠΙΜΕΡΟΥΣ ΣΥΜΠΛΟΚΑ ΤΟΥ TC-99M. ΤΟΥΤΑ ΜΕΛΕΤΗΘΗΚΑΝ ΠΕΡΑΙΤΕΡΩ ΜΕ ΗΛΕΚΤΡΟΦΟΡΗΣΗ (ΦΟΡΤΙΟ, IN VITROΣΤΑΘΕΡΟΤΗΤΑ) ΚΑΙ ΠΡΟΣΔΙΟΡΙΣΤΗΚΕ Η ΛΙΠΟΦΙΛΙΚΟΤΗΤΑ ΤΟΥΣ. ΠΡΟΚΕΙΤΑΙ ΓΙΑ IN VITRO ΣΤΑΘΕΡΑ, ΟΥΔΕΤΕΡΑ ΣΤΟ ΡΗ ΤΟΥ ΑΙΜΑΤΟΣ, ΛΙΠΟΦΙΛΑ ΣΥΜΠΛΟΚΑ ΤΟΥ TC-99M. ΤΑ ΠΛΕΟΝ ΛΙΠΟΦΙΛΑ ΑΠΟ ΑΥΤΑ ΧΟΡΗΓΗΘΗΚΑΝ ΣΕ ΛΕΥΚΑ ΠΟΝΤΙΚΙΑ, ΩΣΤΕ ΝΑ ΜΕΛΕΤΗΘΕΙ Η ΒΙΟΚΑΤΑΝΟΜΗ ΤΟΥΣ, Η ΟΠΟΙΑ ΒΡΕΘΗΚΕ ΧΑΡΑΚΤΗΡΙΣΤΙΚΗ ΓΙΑ ΤΟ ΚΑΘΕ ΣΥΜΠΛΟΚΟ. ΟΡΙΣΜΕΝΑ ΑΠΟ ΑΥΤΑ ΠΑΡΟΥΣΙΑΣΑΝ ΕΝΔΙΑΦΕΡΟΥΣΕΣ ΒΙΟΛΟΓΙΚΕΣ ΙΔΙΟΤΗΤΕΣ (ΚΑΤΑΚΡΑΤΗΣΗ ΣΤΟΝ ΕΓΚΕΦΑΛΟ ΚΑΙ ΣΤΟΜΥΟΚΑΡΔΙΟ). ΓΕΝΙΚΑ ΣΥΜΠΕΡΑΙΝΕΤΑΙ ΟΤΙ ΚΑΤΑ ΤΗΝ ΕΠΙΣΗΜΑΝΣΗ ΤΩΝ ΠΑΡΑΓΩΓΩΝ Ι ΜΕ TC-99M ΣΧΗΜΑΤΙΖΟΝΤΑΙ ΣΥΜΠΛΟΚΑ ΔΙΑΦΟΡΕΤΙΚΗΣ ΔΟΜΗΣ, Η ΟΠΟΙΑ ΕΞΗΓΕΙ ΤΗΝ ΔΙΑΦΟΡΕΤΙΚΗ ΦΥΣΙΚΟΧΗΜΙΚΗ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΤΟΥΣ ΣΥΜΠΕΡΙΦΟΡΑ."]},{"key":"dc:title","label":"Title","values":["ΣΥΝΘΕΣΗ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΜΕΛΕΤΗ ΤΩΝ ΠΑΡΑΓΩΓΩΝ ΤΟΥ 1,8-ΔΙΑΜΙΝΟ-3,6-ΔΙΘΕΙΑ- ΟΚΤΑΝΙΟΥ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99Μ","SYNTHESIS AND BIOLOGICAL STUDY OF 1,8-DIAMINE-3,6-DITHIA-OCTANE DERIVATIVES LABELLED WITH TECHNETIUM-99M"]}]}],"canonical_facts":{"dc:creator":["Μάινα, Θεοδοσία"],"dc:date":["1989"],"dc:description":["A SERIES OF MONO- AND DISUBSTITUTED 1,8-DIAMINE-3,6-DITHIA- OCTANE (I) DERIVATIVES WERE SYNTHESIZED, AS POSSIBLE LIGANDS OF REDUCED TC-99M. THE PRODUCTS WERE CHARACTERIZED BY ELEMENTAL ANALYSIS AND NMR SPECTROSCOPY. THE LIGANDS WERE LABELLED IN AQUEOUS MEDIA WITH TC-99M AFTER ITS REDUCTION WITH NABH4. THEN THE LABELLED COMPOUNDS WERE ANALYZED BY HPLC IN ONE OR MORE 99M TC-SPECIES. THESE WERE FURTHER STUDIED BY ELECTROPHORESIS (CHARGE, IN VITRO STABILITY) AND THEIR LIPOPHILICITY DETERMINED. THEY WERE FOUND TO BE IN STABLE, NEUTRAL IN BLOOD PH LIPOPHILIC 99M TC -COMPLEXES. MOST LIPOPHILIC COMPLEXES WERE ADMINISTERED IN WHITE MICE, IN ORDER TO STUDY THEIR BIODISTRIBUTION, WHICH WAS CHARACTERISTIC FOR EACH COMPLEX. SOME OF THE COMPLEXES EXHIBITED INTERESTING BIOLOGICAL PROPERTIES SUCH AS RETENTION IN BRAIN OR HEART TISSUE. IT IS CONCLUDED, THAT I DERIVATIVES, WHEN LABELLED WITH TC-99M, FORM COMPLEXES OF DIFFERENT STRUCTURE AND THUS EXHIBITING DIFFERENT PHYSICOCHEMICAL AND BIOLOGICAL BEHAVIOUR.","ΕΓΙΝΕ Η ΣΥΝΘΕΣΗ ΣΕΙΡΑΣ ΜΟΝΟ- ΚΑΙ ΔΙΥΠΟΚΑΤΕΣΤΗΜΕΝΩΝ ΠΑΡΑΓΩΓΩΝ ΤΟΥ 1,8-ΔΙΑΜΙΝΟ-3,6-ΔΙΘΕΙΑ-ΟΚΤΑΝΙΟΥ (Ι) ΩΣ ΥΠΟΚΑΤΑΣΤΑΤΩΝ ΤΟΥ ΑΝΑΧΘΕΝΤΟΣ TC-99M. ΟΙ ΥΠΟΚΑΤΑΣΤΑΤΕΣ ΤΑΥΤΟΠΟΙΗΘΗΚΑΝ ΜΕ ΣΤΟΙΧΕΙΑΚΗ ΑΝΑΛΥΣΗ ΚΑΙ ΦΑΣΜΑΤΑ NMR. ΤΑ ΠΑΡΑΓΩΓΑ Ι ΕΠΙΣΗΜΑΝΘΗΚΑΝ ΑΚΟΛΟΥΘΩΣ ΣΕ ΥΔΑΤΙΚΟ ΠΕΡΙΒΑΛΛΟΝ ΜΕ TC-99M ΜΕΤΑ ΤΗΝ ΑΝΑΓΩΓΗ ΤΟΥΤΟΥ ΜΕ NABH2. ΣΤΗ ΣΥΝΕΧΕΙΑ ΤΑ ΡΑΔΙΟΣΗΜΑΣΜΕΝΑ ΠΡΟΙΟΝΤΑ ΔΙΑΧΩΡΙΣΤΗΚΑΝ ΜΕ HPLC ΣΕ ΕΠΙΜΕΡΟΥΣ ΣΥΜΠΛΟΚΑ ΤΟΥ TC-99M. ΤΟΥΤΑ ΜΕΛΕΤΗΘΗΚΑΝ ΠΕΡΑΙΤΕΡΩ ΜΕ ΗΛΕΚΤΡΟΦΟΡΗΣΗ (ΦΟΡΤΙΟ, IN VITROΣΤΑΘΕΡΟΤΗΤΑ) ΚΑΙ ΠΡΟΣΔΙΟΡΙΣΤΗΚΕ Η ΛΙΠΟΦΙΛΙΚΟΤΗΤΑ ΤΟΥΣ. ΠΡΟΚΕΙΤΑΙ ΓΙΑ IN VITRO ΣΤΑΘΕΡΑ, ΟΥΔΕΤΕΡΑ ΣΤΟ ΡΗ ΤΟΥ ΑΙΜΑΤΟΣ, ΛΙΠΟΦΙΛΑ ΣΥΜΠΛΟΚΑ ΤΟΥ TC-99M. ΤΑ ΠΛΕΟΝ ΛΙΠΟΦΙΛΑ ΑΠΟ ΑΥΤΑ ΧΟΡΗΓΗΘΗΚΑΝ ΣΕ ΛΕΥΚΑ ΠΟΝΤΙΚΙΑ, ΩΣΤΕ ΝΑ ΜΕΛΕΤΗΘΕΙ Η ΒΙΟΚΑΤΑΝΟΜΗ ΤΟΥΣ, Η ΟΠΟΙΑ ΒΡΕΘΗΚΕ ΧΑΡΑΚΤΗΡΙΣΤΙΚΗ ΓΙΑ ΤΟ ΚΑΘΕ ΣΥΜΠΛΟΚΟ. ΟΡΙΣΜΕΝΑ ΑΠΟ ΑΥΤΑ ΠΑΡΟΥΣΙΑΣΑΝ ΕΝΔΙΑΦΕΡΟΥΣΕΣ ΒΙΟΛΟΓΙΚΕΣ ΙΔΙΟΤΗΤΕΣ (ΚΑΤΑΚΡΑΤΗΣΗ ΣΤΟΝ ΕΓΚΕΦΑΛΟ ΚΑΙ ΣΤΟΜΥΟΚΑΡΔΙΟ). ΓΕΝΙΚΑ ΣΥΜΠΕΡΑΙΝΕΤΑΙ ΟΤΙ ΚΑΤΑ ΤΗΝ ΕΠΙΣΗΜΑΝΣΗ ΤΩΝ ΠΑΡΑΓΩΓΩΝ Ι ΜΕ TC-99M ΣΧΗΜΑΤΙΖΟΝΤΑΙ ΣΥΜΠΛΟΚΑ ΔΙΑΦΟΡΕΤΙΚΗΣ ΔΟΜΗΣ, Η ΟΠΟΙΑ ΕΞΗΓΕΙ ΤΗΝ ΔΙΑΦΟΡΕΤΙΚΗ ΦΥΣΙΚΟΧΗΜΙΚΗ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΤΟΥΣ ΣΥΜΠΕΡΙΦΟΡΑ."],"dc:identifier":["10.12681/eadd/1171","http://hdl.handle.net/10442/hedi/1171"],"dc:language":["gre"],"dc:publisher":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"],"dc:subject":["1,8-ΔΙΑΜΙΝΟ-3,6-ΔΙΘΕΙΑ-ΟΚΤΑΝΙΟΥ ΠΑΡΑΓΩΓΑ","Διαγνωστική","ΡΑΔΙΟΦΑΡΜΑΚΕΥΤΙΚΗ ΤΕΧΝΟΛΟΓΙΑ","ΥΠΟΚΑΤΑΣΤΑΤΕΣ NXS2 ΓΙΑ ΤΟ TC-99M","ΧΗΛΙΚΕΣ ΕΝΩΣΕΙΣ ΤΟΥ TC-99M ΜΕ ΠΑΡΑΓΩΓΑ NXS2","1,8-DIAMINE-3,6-DITHIA-OCTANE DERIVATIVES","Diagnosis","MULTIDENTATE (NXS2) LICANDS FOR REDUCED TC-99M","RADIOPHARMACEUTICAL TECHNOLOGY","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"],"dc:title":["ΣΥΝΘΕΣΗ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΜΕΛΕΤΗ ΤΩΝ ΠΑΡΑΓΩΓΩΝ ΤΟΥ 1,8-ΔΙΑΜΙΝΟ-3,6-ΔΙΘΕΙΑ- ΟΚΤΑΝΙΟΥ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99Μ","SYNTHESIS AND BIOLOGICAL STUDY OF 1,8-DIAMINE-3,6-DITHIA-OCTANE DERIVATIVES LABELLED WITH TECHNETIUM-99M"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:24:46Z"}