ΑΝΤΙΣΩΜΑΤΑ ΚΑΤΑ ΚΑΡΔΙΟΛΙΠΙΝΗΣ: ΚΛΙΝΙΚΗ ΣΗΜΑΣΙΑ

IN THIS STUDY, A SENSITIVE AND SPECIFIC ELISA METHOD FOR THE QUANTITATIVE DETECTION OF ANTI-CARDIOLIPIN ANTIBODIES (ANTI-CL) WAS DEVELOPED AND SERUM SAMPLES FROM 361 UNSELECTED PATIENTS WITH VARIOUS AUTOIMMUNE RHEUMATIC DISEASES (ARD) ASWELL AS 267 HEALTHY BLOOD DONORS. HIGH LEVELS OF ANTI-CL WERE FOUND MAINLY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSIS AND PATIENTS WITH OVERLAPPING SYNDROMES. THE PRESENCE OF ANTI-CL WAS CORRELATED WITH THE PRESENCE OF CENTRAL NERVOUS SYSTEM INVOLVEMENT (P<0.025) BUT ALSO WITH FEATURES OF IMMUNOLOGICAL HYPERREACTIVITY INCLUDING SPLENOMEGALY AND/OR DIFFUSE LYMPHADENOPATHY (P<0.001) ANTI- NUCLEAR ANTIBODIES (P<0.01), ANTIBODIES TO RO(SSA) (P<0.01), TO U1NRNP (P<0.005)AND TO DOUBLE-STRANDED DNA (P<0.005). THERE WAS NO CORRELATION WITH THE PRESENCE OF THROMBOTIC EVENTS, HEMATOLOGIC OR OBSTETRIC DISORDERS. OUR DATA SUGGEST THAT ANTI-CL CONSTITUTE AN ADDITIONAL ASPECT OF AN UNDERLYING B-CELL HYPERACTIVITY AND CANNOT BE APPLIED AS A MARKER OF ABSOLUTE CLINICAL UTILITY. THESE POINTSWAS FURTHER SUBSTATIATED BY THE FREQUENT DETECTION OF ANTI-CL IN PATIENTS WITHCHRONIC MENTAL DISORDERS (N=304, ASSOTIATION WITH CHLOROPROMAZINE ADMINISTRATION, P<0.003) AND IN HEALTHY ELDERLY INDIVIDUALS (N- 64), POPULATIONS KNOWN TO BE CHARACTERIZED BY HIGH INCIDENCE OF VARIOUS AUTOANTIBODIES.

Grantor dc:publisher

University of Ioannina

Year dc:date

1989

Authors dc:creator

• Manoussakis, Menelaos
• Μανουσάκης, Μενέλαος

• ΑΝΟΣΟΕΝΖΥΜΙΚΗ ΜΕΘΟΔΟΣ - ΣΚΛΗΡΟΔΕΡΜΑ
• Αντισώματα έναντι καρδιολιπίνης
• ΑΝΤΙΣΩΜΑΤΑ ΚΑΤΑ ΦΩΣΦΟΛΙΠΙΔΙΩΝ
• Αυτοάνοσα ρευματικά νοσήματα
• Αυτοαντισώματα
• ΕΦΙΠΠΕΥΟΝΤΑ ΑΥΤΟΑΝΟΣΑ ΣΥΝΔΡΟΜΑ
• ΡΕΥΜΑΤΟΕΙΔΗΣ ΑΡΘΡΙΤΙΔΑ- ΣΥΝΔΡΟΜΟ SJOGREN
• Συστηματικός ερυθηματώδης λύκος ( ΣΕΛ)
• ΥΓΙΗ ΗΛΙΚΙΩΜΕΝΑ ΑΤΟΜΑ
• ΧΡΟΝΙΑ ΨΥΧΙΑΤΡΙΚΑ ΚΑΙ ΔΙΑΝΟΗΤΙΚΑ ΝΟΣΗΜΑΤΑ
• ANTI-CARDIOLIPIN ANTIBODIES
• ANTI-PHOSPHOLIPID ANTIBODIES
• Autoantibodies
• AUTOIMMUNE RHEUMATIC DISEASES
• CHRONIC PSYCHIATRIC AND MENTAL DISORDERS
• ENZYME-LINKED IMMUNOSORBENT ASSAY - SCLERODERMA
• HEALTHY ELDERLY INDIVIDUALS
• OVERLAPPING AUTOIMMUNE SYNDROMES
• RHEUMATOID ARTHRITIS - SJOGREN'S SYNDROME
• Systemic lupus erythematosus ( SLE)
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/1114

OAI identifier oai:identifier

oai:10442/1114