{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1114"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1114","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΑΝΤΙΣΩΜΑΤΑ ΚΑΤΑ ΚΑΡΔΙΟΛΙΠΙΝΗΣ: ΚΛΙΝΙΚΗ ΣΗΜΑΣΙΑ","abstract":"IN THIS STUDY, A SENSITIVE AND SPECIFIC ELISA METHOD FOR THE QUANTITATIVE DETECTION OF ANTI-CARDIOLIPIN ANTIBODIES (ANTI-CL) WAS DEVELOPED AND SERUM SAMPLES FROM 361 UNSELECTED PATIENTS WITH VARIOUS AUTOIMMUNE RHEUMATIC DISEASES (ARD) ASWELL AS 267 HEALTHY BLOOD DONORS. HIGH LEVELS OF ANTI-CL WERE FOUND MAINLY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSIS AND PATIENTS WITH OVERLAPPING SYNDROMES. THE PRESENCE OF ANTI-CL WAS CORRELATED WITH THE PRESENCE OF CENTRAL NERVOUS SYSTEM INVOLVEMENT (P<0.025) BUT ALSO WITH FEATURES OF IMMUNOLOGICAL HYPERREACTIVITY INCLUDING SPLENOMEGALY AND/OR DIFFUSE LYMPHADENOPATHY (P<0.001) ANTI- NUCLEAR ANTIBODIES (P<0.01), ANTIBODIES TO RO(SSA) (P<0.01), TO U1NRNP (P<0.005)AND TO DOUBLE-STRANDED DNA (P<0.005). THERE WAS NO CORRELATION WITH THE PRESENCE OF THROMBOTIC EVENTS, HEMATOLOGIC OR OBSTETRIC DISORDERS. OUR DATA SUGGEST THAT ANTI-CL CONSTITUTE AN ADDITIONAL ASPECT OF AN UNDERLYING B-CELL HYPERACTIVITY AND CANNOT BE APPLIED AS A MARKER OF ABSOLUTE CLINICAL UTILITY. THESE POINTSWAS FURTHER SUBSTATIATED BY THE FREQUENT DETECTION OF ANTI-CL IN PATIENTS WITHCHRONIC MENTAL DISORDERS (N=304, ASSOTIATION WITH CHLOROPROMAZINE ADMINISTRATION, P<0.003) AND IN HEALTHY ELDERLY INDIVIDUALS (N- 64), POPULATIONS KNOWN TO BE CHARACTERIZED BY HIGH INCIDENCE OF VARIOUS AUTOANTIBODIES.","abstract_html":"IN THIS STUDY, A SENSITIVE AND SPECIFIC ELISA METHOD FOR THE QUANTITATIVE DETECTION OF ANTI-CARDIOLIPIN ANTIBODIES (ANTI-CL) WAS DEVELOPED AND SERUM SAMPLES FROM 361 UNSELECTED PATIENTS WITH VARIOUS AUTOIMMUNE RHEUMATIC DISEASES (ARD) ASWELL AS 267 HEALTHY BLOOD DONORS. HIGH LEVELS OF ANTI-CL WERE FOUND MAINLY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSIS AND PATIENTS WITH OVERLAPPING SYNDROMES. THE PRESENCE OF ANTI-CL WAS CORRELATED WITH THE PRESENCE OF CENTRAL NERVOUS SYSTEM INVOLVEMENT (P&lt;0.025) BUT ALSO WITH FEATURES OF IMMUNOLOGICAL HYPERREACTIVITY INCLUDING SPLENOMEGALY AND/OR DIFFUSE LYMPHADENOPATHY (P&lt;0.001) ANTI- NUCLEAR ANTIBODIES (P&lt;0.01), ANTIBODIES TO RO(SSA) (P&lt;0.01), TO U1NRNP (P&lt;0.005)AND TO DOUBLE-STRANDED DNA (P&lt;0.005). THERE WAS NO CORRELATION WITH THE PRESENCE OF THROMBOTIC EVENTS, HEMATOLOGIC OR OBSTETRIC DISORDERS. OUR DATA SUGGEST THAT ANTI-CL CONSTITUTE AN ADDITIONAL ASPECT OF AN UNDERLYING B-CELL HYPERACTIVITY AND CANNOT BE APPLIED AS A MARKER OF ABSOLUTE CLINICAL UTILITY. THESE POINTSWAS FURTHER SUBSTATIATED BY THE FREQUENT DETECTION OF ANTI-CL IN PATIENTS WITHCHRONIC MENTAL DISORDERS (N=304, ASSOTIATION WITH CHLOROPROMAZINE ADMINISTRATION, P&lt;0.003) AND IN HEALTHY ELDERLY INDIVIDUALS (N- 64), POPULATIONS KNOWN TO BE CHARACTERIZED BY HIGH INCIDENCE OF VARIOUS AUTOANTIBODIES.","abstract_has_math":false,"creators":["Manoussakis, Menelaos","Μανουσάκης, Μενέλαος"],"institution":"University of Ioannina","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1989,"date_issued":"1989","date_published":"1989","updated_at":"2026-07-24T02:24:43Z","subjects":["ΑΝΟΣΟΕΝΖΥΜΙΚΗ ΜΕΘΟΔΟΣ - ΣΚΛΗΡΟΔΕΡΜΑ","Αντισώματα έναντι καρδιολιπίνης","ΑΝΤΙΣΩΜΑΤΑ ΚΑΤΑ ΦΩΣΦΟΛΙΠΙΔΙΩΝ","Αυτοάνοσα ρευματικά νοσήματα","Αυτοαντισώματα","ΕΦΙΠΠΕΥΟΝΤΑ ΑΥΤΟΑΝΟΣΑ ΣΥΝΔΡΟΜΑ","ΡΕΥΜΑΤΟΕΙΔΗΣ ΑΡΘΡΙΤΙΔΑ- ΣΥΝΔΡΟΜΟ SJOGREN","Συστηματικός ερυθηματώδης λύκος ( ΣΕΛ)","ΥΓΙΗ ΗΛΙΚΙΩΜΕΝΑ ΑΤΟΜΑ","ΧΡΟΝΙΑ ΨΥΧΙΑΤΡΙΚΑ ΚΑΙ ΔΙΑΝΟΗΤΙΚΑ ΝΟΣΗΜΑΤΑ","ANTI-CARDIOLIPIN ANTIBODIES","ANTI-PHOSPHOLIPID ANTIBODIES","Autoantibodies","AUTOIMMUNE RHEUMATIC DISEASES","CHRONIC PSYCHIATRIC AND MENTAL DISORDERS","ENZYME-LINKED IMMUNOSORBENT ASSAY - SCLERODERMA","HEALTHY ELDERLY INDIVIDUALS","OVERLAPPING AUTOIMMUNE SYNDROMES","RHEUMATOID ARTHRITIS - SJOGREN'S SYNDROME","Systemic lupus erythematosus ( SLE)","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1114"],"render_values":[{"text":"10.12681/eadd/1114","href":"https://doi.org/10.12681/eadd/1114","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1114","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Manoussakis, Menelaos","Μανουσάκης, Μενέλαος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1989"]},{"key":"dc:publisher","label":"Institution","values":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ΑΝΟΣΟΕΝΖΥΜΙΚΗ ΜΕΘΟΔΟΣ - ΣΚΛΗΡΟΔΕΡΜΑ","Αντισώματα έναντι καρδιολιπίνης","ΑΝΤΙΣΩΜΑΤΑ ΚΑΤΑ ΦΩΣΦΟΛΙΠΙΔΙΩΝ","Αυτοάνοσα ρευματικά νοσήματα","Αυτοαντισώματα","ΕΦΙΠΠΕΥΟΝΤΑ ΑΥΤΟΑΝΟΣΑ ΣΥΝΔΡΟΜΑ","ΡΕΥΜΑΤΟΕΙΔΗΣ ΑΡΘΡΙΤΙΔΑ- ΣΥΝΔΡΟΜΟ SJOGREN","Συστηματικός ερυθηματώδης λύκος ( ΣΕΛ)","ΥΓΙΗ ΗΛΙΚΙΩΜΕΝΑ ΑΤΟΜΑ","ΧΡΟΝΙΑ ΨΥΧΙΑΤΡΙΚΑ ΚΑΙ ΔΙΑΝΟΗΤΙΚΑ ΝΟΣΗΜΑΤΑ","ANTI-CARDIOLIPIN ANTIBODIES","ANTI-PHOSPHOLIPID ANTIBODIES","Autoantibodies","AUTOIMMUNE RHEUMATIC DISEASES","CHRONIC PSYCHIATRIC AND MENTAL DISORDERS","ENZYME-LINKED IMMUNOSORBENT ASSAY - SCLERODERMA","HEALTHY ELDERLY INDIVIDUALS","OVERLAPPING AUTOIMMUNE SYNDROMES","RHEUMATOID ARTHRITIS - SJOGREN'S SYNDROME","Systemic lupus erythematosus ( SLE)","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1114","http://hdl.handle.net/10442/hedi/1114"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["IN THIS STUDY, A SENSITIVE AND SPECIFIC ELISA METHOD FOR THE QUANTITATIVE DETECTION OF ANTI-CARDIOLIPIN ANTIBODIES (ANTI-CL) WAS DEVELOPED AND SERUM SAMPLES FROM 361 UNSELECTED PATIENTS WITH VARIOUS AUTOIMMUNE RHEUMATIC DISEASES (ARD) ASWELL AS 267 HEALTHY BLOOD DONORS. HIGH LEVELS OF ANTI-CL WERE FOUND MAINLY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSIS AND PATIENTS WITH OVERLAPPING SYNDROMES. THE PRESENCE OF ANTI-CL WAS CORRELATED WITH THE PRESENCE OF CENTRAL NERVOUS SYSTEM INVOLVEMENT (P<0.025) BUT ALSO WITH FEATURES OF IMMUNOLOGICAL HYPERREACTIVITY INCLUDING SPLENOMEGALY AND/OR DIFFUSE LYMPHADENOPATHY (P<0.001) ANTI- NUCLEAR ANTIBODIES (P<0.01), ANTIBODIES TO RO(SSA) (P<0.01), TO U1NRNP (P<0.005)AND TO DOUBLE-STRANDED DNA (P<0.005). THERE WAS NO CORRELATION WITH THE PRESENCE OF THROMBOTIC EVENTS, HEMATOLOGIC OR OBSTETRIC DISORDERS. OUR DATA SUGGEST THAT ANTI-CL CONSTITUTE AN ADDITIONAL ASPECT OF AN UNDERLYING B-CELL HYPERACTIVITY AND CANNOT BE APPLIED AS A MARKER OF ABSOLUTE CLINICAL UTILITY. THESE POINTSWAS FURTHER SUBSTATIATED BY THE FREQUENT DETECTION OF ANTI-CL IN PATIENTS WITHCHRONIC MENTAL DISORDERS (N=304, ASSOTIATION WITH CHLOROPROMAZINE ADMINISTRATION, P<0.003) AND IN HEALTHY ELDERLY INDIVIDUALS (N- 64), POPULATIONS KNOWN TO BE CHARACTERIZED BY HIGH INCIDENCE OF VARIOUS AUTOANTIBODIES.","ΣΤΗΝ ΜΕΛΕΤΗ ΑΥΤΗ ΑΝΑΠΤΥΧΘΗΚΕ ΕΥΑΙΣΘΗΤΗ ΚΑΙ ΕΙΔΙΚΗ ΑΝΟΣΟΕΝΖΥΜΙΚΗ ΜΕΘΟΔΟΣ ΓΙΑ ΤΗΝΠΟΣΟΤΙΚΗ ΑΝΙΧΝΕΥΣΗ ΤΩΝ IGG ΚΑΙ IGM ΑΝΤΙΣΩΜΑΤΩΝ ΚΑΤΑ ΚΑΡΔΙΟΛΙΠΙΝΗΣ (ΑΝΤΙ-ΚΛ), ΜΕ ΤΗΝ ΟΠΟΙΑ ΜΕΛΕΤΗΘΗΚΑΝ ΔΕΙΓΜΑΤΑ ΟΡΟΥ ΑΙΜΑΤΟΣ ΑΠΟ 361 ΜΗ ΕΠΙΛΕΓΜΕΝΟΥΣ ΑΣΘΕΝΕΙΣ,267 ΥΓΙΕΙΣ ΑΙΜΟΔΟΤΕΣ. ΘΕΤΙΚΑ ΕΠΙΠΕΔΑ ΑΝΤΙ-ΚΛ ΑΝΕΥΡΕΘΗΣΑΝ ΚΥΡΙΩΣ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕΣΥΣΤΗΜΑΤΙΚΟ ΕΡΥΘΗΜΑΤΩΔΗ ΛΥΚΟ (ΣΕΛ) ΚΑΙ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΕΦΙΠΠΕΥΟΝΤΑ ΣΥΝΔΡΟΜΑ. Η ΠΑΡΟΥΣΙΑ ΑΝΤΙ-ΚΛ ΣΥΣΧΕΤΙΖΟΤΑΝ ΣΤΑΤΙΣΤΙΚΑ ΜΕ ΤΗΝ ΠΑΡΟΥΣΙΑ ΠΡΟΣΒΟΛΗΣ ΤΟΥ ΚΕΝΤΡΙΚΟΥ ΝΕΥΡΙΚΟΥ ΣΥΣΤΗΜΑΤΟΣ (ΕΠΙΛΗΨΙΑ, Ρ<0.025) ΚΑΘΩΣ ΕΠΙΣΗΣ ΚΑΙ ΜΕ ΦΑΙΝΟΜΕΝΑ ΑΝΟΣΟΛΟΓΙΚΗΣ ΥΠΕΡΔΡΑΣΤΗΡΙΟΤΗΤΑΣ ΟΠΩΣ ΣΠΛΗΝΟΜΕΓΑΛΙΑ 'Η/ΚΑΙ ΔΙΑΧΥΤΗ ΛΕΜΦΑΔΕΝΟΠΑΘΕΙΑ (Ρ<0.001), ΑΝΤΙΣΩΜΑΤΑ ΚΑΤΑ ΠΥΡΗΝΙΚΩΝ ΑΝΤΙΓΟΝΩΝ (Ρ<0.01), ΚΑΤΑ RO(SSA) (Ρ<0.01), ΚΑΤΑ U1NRNP (P<0.05) ΚΑΙ ΚΑΤΑ ΔΙΠΛΗΣ ΕΛΙΚΟΣ DNA (Ρ<0.005) ΕΝΩ ΔΕΝ ΥΠΗΡΧΕ ΣΥΣΧΕΤΙΣΗΜΕ ΤΗΝ ΠΑΡΟΥΣΙΑ ΘΡΟΜΒΩΣΕΩΝ, ΑΙΜΑΤΟΛΟΓΙΚΩΝ 'Η ΜΑΙΕΥΤΙΚΩΝ ΔΙΑΤΑΡΑΧΩΝ. ΤΑ ΕΥΡΗΜΑΤΑ ΜΑΣ ΥΠΟΔΕΙΚΝΥΟΥΝ ΟΤΙ ΤΑ ΑΝΤΙ-ΚΛ ΑΠΟΤΕΛΟΥΝ ΜΙΑ ΕΚΦΑΝΣΗ ΜΙΑΣ ΥΠΟΚΕΙΜΕΝΗΣ ΑΝΟΣΟΛΟΓΙΚΗΣ ΥΠΕΡΔΡΑΣΤΗΡΙΟΤΗΤΑΣ ΧΩΡΙΣ ΟΜΩΣ ΝΑ ΕΧΟΥΝ ΑΠΟΛΥΤΗ ΧΡΗΣΙΜΟΤΗΤΑ ΓΙΑ ΤΗΝ ΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΤΩΝ ΑΥΤΟΑΝΟΣΩΝ ΑΣΘΕΝΩΝ. ΑΥΤΟ ΕΠΙΠΛΕΟΝ ΥΠΟΓΡΑΜΜΙΖΕΤΑΙ ΑΠΟ ΤΗΝ ΑΝΕΥΡΕΣΗ ΑΝΤΙ-ΚΛ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΧΡΟΝΙΑ ΨΥΧΙΑΤΡΙΚΑ ΚΑΙ ΔΙΑΝΟΗΤΙΚΑ ΝΟΣΗΜΑΤΑ (N=304, ΣΥΣΧΕΤΙΣΗ ΜΕ ΤΗΝ ΛΗΨΗ ΧΛΩΡΟΠΡΟΜΑΖΙΝΗΣ, Ρ<0.03) ΚΑΙ ΣΕ ΥΓΙΗ ΗΛΙΚΙΩΜΕΝΑ ΑΤΟΜΑ (Ν=64) ΔΕΔΟΜΕΝΟΥ ΟΤΙ ΟΙ ΟΜΑΔΕΣ ΑΥΤΕΣ ΧΑΡΑΚΤΗΡΙΖΟΝΤΑΙ ΑΠΟ ΥΨΗΛΗ ΣΥΧΝΟΤΗΤΑ ΠΟΙΚΙΛΩΝ ΑΥΤΟΑΝΤΙΣΩΜΑΤΩΝ."]},{"key":"dc:title","label":"Title","values":["ΑΝΤΙΣΩΜΑΤΑ ΚΑΤΑ ΚΑΡΔΙΟΛΙΠΙΝΗΣ: ΚΛΙΝΙΚΗ ΣΗΜΑΣΙΑ","ANTI-CARDIOLIPIN ANTIBODIES: CLINICAL SIGNIFICANCE"]}]}],"canonical_facts":{"dc:creator":["Manoussakis, Menelaos","Μανουσάκης, Μενέλαος"],"dc:date":["1989"],"dc:description":["IN THIS STUDY, A SENSITIVE AND SPECIFIC ELISA METHOD FOR THE QUANTITATIVE DETECTION OF ANTI-CARDIOLIPIN ANTIBODIES (ANTI-CL) WAS DEVELOPED AND SERUM SAMPLES FROM 361 UNSELECTED PATIENTS WITH VARIOUS AUTOIMMUNE RHEUMATIC DISEASES (ARD) ASWELL AS 267 HEALTHY BLOOD DONORS. HIGH LEVELS OF ANTI-CL WERE FOUND MAINLY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSIS AND PATIENTS WITH OVERLAPPING SYNDROMES. THE PRESENCE OF ANTI-CL WAS CORRELATED WITH THE PRESENCE OF CENTRAL NERVOUS SYSTEM INVOLVEMENT (P<0.025) BUT ALSO WITH FEATURES OF IMMUNOLOGICAL HYPERREACTIVITY INCLUDING SPLENOMEGALY AND/OR DIFFUSE LYMPHADENOPATHY (P<0.001) ANTI- NUCLEAR ANTIBODIES (P<0.01), ANTIBODIES TO RO(SSA) (P<0.01), TO U1NRNP (P<0.005)AND TO DOUBLE-STRANDED DNA (P<0.005). THERE WAS NO CORRELATION WITH THE PRESENCE OF THROMBOTIC EVENTS, HEMATOLOGIC OR OBSTETRIC DISORDERS. OUR DATA SUGGEST THAT ANTI-CL CONSTITUTE AN ADDITIONAL ASPECT OF AN UNDERLYING B-CELL HYPERACTIVITY AND CANNOT BE APPLIED AS A MARKER OF ABSOLUTE CLINICAL UTILITY. THESE POINTSWAS FURTHER SUBSTATIATED BY THE FREQUENT DETECTION OF ANTI-CL IN PATIENTS WITHCHRONIC MENTAL DISORDERS (N=304, ASSOTIATION WITH CHLOROPROMAZINE ADMINISTRATION, P<0.003) AND IN HEALTHY ELDERLY INDIVIDUALS (N- 64), POPULATIONS KNOWN TO BE CHARACTERIZED BY HIGH INCIDENCE OF VARIOUS AUTOANTIBODIES.","ΣΤΗΝ ΜΕΛΕΤΗ ΑΥΤΗ ΑΝΑΠΤΥΧΘΗΚΕ ΕΥΑΙΣΘΗΤΗ ΚΑΙ ΕΙΔΙΚΗ ΑΝΟΣΟΕΝΖΥΜΙΚΗ ΜΕΘΟΔΟΣ ΓΙΑ ΤΗΝΠΟΣΟΤΙΚΗ ΑΝΙΧΝΕΥΣΗ ΤΩΝ IGG ΚΑΙ IGM ΑΝΤΙΣΩΜΑΤΩΝ ΚΑΤΑ ΚΑΡΔΙΟΛΙΠΙΝΗΣ (ΑΝΤΙ-ΚΛ), ΜΕ ΤΗΝ ΟΠΟΙΑ ΜΕΛΕΤΗΘΗΚΑΝ ΔΕΙΓΜΑΤΑ ΟΡΟΥ ΑΙΜΑΤΟΣ ΑΠΟ 361 ΜΗ ΕΠΙΛΕΓΜΕΝΟΥΣ ΑΣΘΕΝΕΙΣ,267 ΥΓΙΕΙΣ ΑΙΜΟΔΟΤΕΣ. ΘΕΤΙΚΑ ΕΠΙΠΕΔΑ ΑΝΤΙ-ΚΛ ΑΝΕΥΡΕΘΗΣΑΝ ΚΥΡΙΩΣ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕΣΥΣΤΗΜΑΤΙΚΟ ΕΡΥΘΗΜΑΤΩΔΗ ΛΥΚΟ (ΣΕΛ) ΚΑΙ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΕΦΙΠΠΕΥΟΝΤΑ ΣΥΝΔΡΟΜΑ. Η ΠΑΡΟΥΣΙΑ ΑΝΤΙ-ΚΛ ΣΥΣΧΕΤΙΖΟΤΑΝ ΣΤΑΤΙΣΤΙΚΑ ΜΕ ΤΗΝ ΠΑΡΟΥΣΙΑ ΠΡΟΣΒΟΛΗΣ ΤΟΥ ΚΕΝΤΡΙΚΟΥ ΝΕΥΡΙΚΟΥ ΣΥΣΤΗΜΑΤΟΣ (ΕΠΙΛΗΨΙΑ, Ρ<0.025) ΚΑΘΩΣ ΕΠΙΣΗΣ ΚΑΙ ΜΕ ΦΑΙΝΟΜΕΝΑ ΑΝΟΣΟΛΟΓΙΚΗΣ ΥΠΕΡΔΡΑΣΤΗΡΙΟΤΗΤΑΣ ΟΠΩΣ ΣΠΛΗΝΟΜΕΓΑΛΙΑ 'Η/ΚΑΙ ΔΙΑΧΥΤΗ ΛΕΜΦΑΔΕΝΟΠΑΘΕΙΑ (Ρ<0.001), ΑΝΤΙΣΩΜΑΤΑ ΚΑΤΑ ΠΥΡΗΝΙΚΩΝ ΑΝΤΙΓΟΝΩΝ (Ρ<0.01), ΚΑΤΑ RO(SSA) (Ρ<0.01), ΚΑΤΑ U1NRNP (P<0.05) ΚΑΙ ΚΑΤΑ ΔΙΠΛΗΣ ΕΛΙΚΟΣ DNA (Ρ<0.005) ΕΝΩ ΔΕΝ ΥΠΗΡΧΕ ΣΥΣΧΕΤΙΣΗΜΕ ΤΗΝ ΠΑΡΟΥΣΙΑ ΘΡΟΜΒΩΣΕΩΝ, ΑΙΜΑΤΟΛΟΓΙΚΩΝ 'Η ΜΑΙΕΥΤΙΚΩΝ ΔΙΑΤΑΡΑΧΩΝ. ΤΑ ΕΥΡΗΜΑΤΑ ΜΑΣ ΥΠΟΔΕΙΚΝΥΟΥΝ ΟΤΙ ΤΑ ΑΝΤΙ-ΚΛ ΑΠΟΤΕΛΟΥΝ ΜΙΑ ΕΚΦΑΝΣΗ ΜΙΑΣ ΥΠΟΚΕΙΜΕΝΗΣ ΑΝΟΣΟΛΟΓΙΚΗΣ ΥΠΕΡΔΡΑΣΤΗΡΙΟΤΗΤΑΣ ΧΩΡΙΣ ΟΜΩΣ ΝΑ ΕΧΟΥΝ ΑΠΟΛΥΤΗ ΧΡΗΣΙΜΟΤΗΤΑ ΓΙΑ ΤΗΝ ΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΤΩΝ ΑΥΤΟΑΝΟΣΩΝ ΑΣΘΕΝΩΝ. ΑΥΤΟ ΕΠΙΠΛΕΟΝ ΥΠΟΓΡΑΜΜΙΖΕΤΑΙ ΑΠΟ ΤΗΝ ΑΝΕΥΡΕΣΗ ΑΝΤΙ-ΚΛ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΧΡΟΝΙΑ ΨΥΧΙΑΤΡΙΚΑ ΚΑΙ ΔΙΑΝΟΗΤΙΚΑ ΝΟΣΗΜΑΤΑ (N=304, ΣΥΣΧΕΤΙΣΗ ΜΕ ΤΗΝ ΛΗΨΗ ΧΛΩΡΟΠΡΟΜΑΖΙΝΗΣ, Ρ<0.03) ΚΑΙ ΣΕ ΥΓΙΗ ΗΛΙΚΙΩΜΕΝΑ ΑΤΟΜΑ (Ν=64) ΔΕΔΟΜΕΝΟΥ ΟΤΙ ΟΙ ΟΜΑΔΕΣ ΑΥΤΕΣ ΧΑΡΑΚΤΗΡΙΖΟΝΤΑΙ ΑΠΟ ΥΨΗΛΗ ΣΥΧΝΟΤΗΤΑ ΠΟΙΚΙΛΩΝ ΑΥΤΟΑΝΤΙΣΩΜΑΤΩΝ."],"dc:identifier":["10.12681/eadd/1114","http://hdl.handle.net/10442/hedi/1114"],"dc:language":["gre"],"dc:publisher":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"],"dc:subject":["ΑΝΟΣΟΕΝΖΥΜΙΚΗ ΜΕΘΟΔΟΣ - ΣΚΛΗΡΟΔΕΡΜΑ","Αντισώματα έναντι καρδιολιπίνης","ΑΝΤΙΣΩΜΑΤΑ ΚΑΤΑ ΦΩΣΦΟΛΙΠΙΔΙΩΝ","Αυτοάνοσα ρευματικά νοσήματα","Αυτοαντισώματα","ΕΦΙΠΠΕΥΟΝΤΑ ΑΥΤΟΑΝΟΣΑ ΣΥΝΔΡΟΜΑ","ΡΕΥΜΑΤΟΕΙΔΗΣ ΑΡΘΡΙΤΙΔΑ- ΣΥΝΔΡΟΜΟ SJOGREN","Συστηματικός ερυθηματώδης λύκος ( ΣΕΛ)","ΥΓΙΗ ΗΛΙΚΙΩΜΕΝΑ ΑΤΟΜΑ","ΧΡΟΝΙΑ ΨΥΧΙΑΤΡΙΚΑ ΚΑΙ ΔΙΑΝΟΗΤΙΚΑ ΝΟΣΗΜΑΤΑ","ANTI-CARDIOLIPIN ANTIBODIES","ANTI-PHOSPHOLIPID ANTIBODIES","Autoantibodies","AUTOIMMUNE RHEUMATIC DISEASES","CHRONIC PSYCHIATRIC AND MENTAL DISORDERS","ENZYME-LINKED IMMUNOSORBENT ASSAY - SCLERODERMA","HEALTHY ELDERLY INDIVIDUALS","OVERLAPPING AUTOIMMUNE SYNDROMES","RHEUMATOID ARTHRITIS - SJOGREN'S SYNDROME","Systemic lupus erythematosus ( SLE)","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"dc:title":["ΑΝΤΙΣΩΜΑΤΑ ΚΑΤΑ ΚΑΡΔΙΟΛΙΠΙΝΗΣ: ΚΛΙΝΙΚΗ ΣΗΜΑΣΙΑ","ANTI-CARDIOLIPIN ANTIBODIES: CLINICAL SIGNIFICANCE"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:24:43Z"}