Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΤΑΥΤΟΧΡΟΝΗΣ ΧΟΡΗΓΗΣΗΣ ΦΑΙΝΥΛΒΟΥΤΑΖΟΝΗΣ Η ΙΝΔΟΜΕΘΑΚΙΝΗΣ ΣΤΑ ΕΠΙΠΕΔΑ ΤΗΣ ΚΕΦΑΛΥΡΙΝΗΣ ΣΤΟΝ ΟΡΟ ΚΑΙ ΣΤΑ ΟΣΤΑ ΤΗΣ ΚΑΤΩ ΓΝΑΘΟΥ

THE EFFECT OF SIMULTANEOUS ADMINISTRATION OF TWO ANTI- INFLAMMATORY DRUGS (PHENYLBUTAZONE, INDOMETHACIN), ON THE LEVELS OF CEPHAPIRIN IN SERUM AND MANDIBLE WAS STUDIED IN RATS, TWO, FIVE AND EIGHT HOURS AFTER THE LAST SUBCUTANEOUS INJECTION. A HUNDRED AND EIGHT MALE WISTAR ALBINO RATS DIVIDED IN FIVE GROUPS WERE USED FOR THIS STUDY. THEIR MEAN BODY WEIGHT WAS 260 G. - THE ANIMALS OF THE FIRSTGROUP RECEIVED CEPHAPIRIN (CEFATREX) 500 MG/KG EVERY EIGHT HOURS FOR 24 HOURS.- THE ANIMALS OF THE SECOND GROUP RECEIVED CEPHAPRIRIN LIKE THE FIRST GROUP AND ADDITIONALLY PHENYLBUTAZONE (BUTAZOLIDIN) 100 MG/KG IN A SINGLE DOSE. - THE ANIMALSOF THE THIRD GROUP RECEIVED CEPHAPIRIN AND INDOMETHACIN (INDOCID) 2 MG/KGEVERY EIGHT HOURS FOR 24 HOURS. - TO THE ANIMALS OF THE FOURTH NAD FIFTH GROUPPHENYLBUTAZONE AND INDOMETHACIN WAS ADMINISTERED RESPECTIVELY. LEVELS OF THE ANTIBIOTIC IN SERUM AND MANDIBLE WERE ESTIMATED BY THE METHOD OF MINIMAL INHIBITORY CONCENTRATION (MIC). FROM THE RESULTS AND STATISTICAL ANALYSIS THE FOLLOWING CAN BE CONCLUDED: A) THE INCREASE OF LEVELS OF CEPHAPIRIN IN SERUM AND MANDIBLE AFTER SIMULTANEOUS ADMINISTRATION OF PHENYLBUTAZONE WAS STATISTICALLY SIGNIFICANT. B) THE CONCENTRATION OF CEPHAPIRIN AFTER SIMULTANEOUS ADMINISTRATION OF INDOMETHACIN WAS INCREASED AS WELL BUT THE INCREASE WAS STATISTICALLY SIGNIFICANT ONLY IN THE MANDIBLE, NOT IN SERUM. C) FIVE HOURS AFTER THE LAST ADMINISTRATION CEPHAPIRIN WAS NOT DETECTED IN THE MANDIBLE AND EIGHT HOURS AFTER THE LAST ADMINISTRATION CEPHAPIRIN WAS NOT DETECTED IN THE SERUM EITHER.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1987

Authors dc:creator

• Gritzalis, Panagiotis
• Γκριτζαλής, Παναγιώτης

• Ινδομεθακίνη
• Κάτω γνάθος
• Κεφαπυρίνη
• Φαινυλβουταζόνη
• Cephapirin
• Indomethacin
• Mandible
• PHENYLBOTAZONE
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0806

OAI identifier oai:identifier

oai:10442/0806