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Showing 1 to 20 of 95 for “"Indomethacin"”.
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The effect of indomethacin on glomerular permeability in the nephrotic syndrome
Contains fulltext : mmubn000001_246061790.pdf (Publisher’s version ) (Open Access)
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Solubility Improvement by Solid Dispersion and Their Characterization: Indomethacin and Phenytoin
… of two poorly water soluble drugs, namely indomethacin and phenytoin by formulating ternary solid dispersions with a carrier and an adsorbent. Urea was used as the dispersing agent for indomethacin, while Kollidon<sup>®</sup>VA64 was used for both indomethacin and phenytoin. Solid …
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Crystalline Salt Formation of an Acidic Drug Indomethacin Using Hot Melt Extrusion Technology
… Herein, we show that the dissolution rate of indomethacin (a poorly water-soluble drug) can be increased by using hot melt extrusion of a 1:1 (mol/mol) indomethacin:tromethamine mixture to form a highly crystalline salt, the physicochemical properties of which are investigated in detail. …
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Factors That Enhance Pituitary and Ovarian Functions in Postpartum Beef Cows (Naloxane, Gn-Rh, Pgf(2), Indomethacin)
Currently and for several years ahead of it becomes ideal that each beef cow should produce one calf every year in order to sustain an economically viable cow-calf operation. In actual farm settings, however, this ideal condition is seldom achieved because of a variety of factors that act singly or …
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The role of inflammation in delayed muscle soreness (DMS) and the effects of indomethacin on DMS and perceived exertion
… second objective was to determine the effects of indomethacin (Id) on RPE. Thirty-nine males were randomly assigned to a drug (Id) or placebo (P) group and administered 150 mg indomechacin or placebo, beginning 36 h prior to stepping. Results indicated no significant differences between RPE for …
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Effect of indomethacin (a prostaglandin inhibitor) on the ovulatory cycle, total plasma calcium, and egg shell thickness in the domestic laying hen (Gallus domesticus)
Thesis (M.S.)--Michigan State University. Dept. of Poultry Science,
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Arachidonic acid metabolism by early ovine embryos and the role of prostaglandins in one aspect of embryonic development
… Embryos were incubated with ethanol (control), indomethacin, PGE₂ or indomethacin and PGE₂ in an atmosphere of 5% CO₂ and 95% air at 37°C for 24 h. Indomethacin appeared to decrease embryo hatching rate (indomethacin, 34.5% vs control, 46.4%). Prostaglandin E₂ appeared to increase embryo …
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The gastrointestinal effects of calcitonin and related peptides
… The hypocalcaemic actions and the actions on indomethacin-induced gastric erosions of calcitonin, icatacalcin and calcitonin gene-related peptide (CGRP) were found to be very different. Whilst calcitonin was shown to have both hypocalcaemic and anti-ulcerogenic actions, katacalcin demonstrated …
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Nonsteroidal anti-inflammatory drugs and prostaglandin synthesis inhibitors in the treatment of urinary diseases and their effects on renal functions: clinical studies
… nonsteroidal anti-inflammatory drugs (NSAIDs), indomethacin suppositories or diclofenac sodium, or by carbamazepine, were used in their management. Measurement of urine volume and urinary and serum electrolytes and osmolality were performed before and after treatment with indomethacin. Similar …
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Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΤΑΥΤΟΧΡΟΝΗΣ ΧΟΡΗΓΗΣΗΣ ΦΑΙΝΥΛΒΟΥΤΑΖΟΝΗΣ Η ΙΝΔΟΜΕΘΑΚΙΝΗΣ ΣΤΑ ΕΠΙΠΕΔΑ ΤΗΣ ΚΕΦΑΛΥΡΙΝΗΣ ΣΤΟΝ ΟΡΟ ΚΑΙ ΣΤΑ ΟΣΤΑ ΤΗΣ ΚΑΤΩ ΓΝΑΘΟΥ
… OF TWO ANTI- INFLAMMATORY DRUGS (PHENYLBUTAZONE, INDOMETHACIN), ON THE LEVELS OF CEPHAPIRIN IN SERUM AND MANDIBLE WAS STUDIED IN RATS, TWO, FIVE AND EIGHT HOURS AFTER THE LAST SUBCUTANEOUS INJECTION. A HUNDRED AND EIGHT MALE WISTAR ALBINO RATS DIVIDED IN FIVE GROUPS WERE USED FOR THIS STUDY. THEIR …
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Solid dispersions: formulation, characterisation, permeability and genomic evaluation
… paracetamol, sulphamethoxazole, phenacetin, indomethacin, chloramphenicol, phenylbutazone and succinylsulphathiazole. Solid dispersions were prepared using various drugs to polymer ratios. PEG 8000 was selected as a carrier in the solid dispersions. The study revealed that inclusion of drug …
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ΛΕΙΤΟΥΡΓΙΚΟΤΗΤΑ ΤΟΥ ΑΓΓΕΙΑΚΟΥ ΠΝΕΥΜΟΝΙΚΟΥ ΕΝΔΟΘΗΛΙΟΥ, IN VIVO, ΥΠΟ ΦΥΣΙΟΛΟΓΙΚΕΣ ΚΑΙ ΠΑΘΟΛΟΓΙΚΕΣ ΣΥΝΘΗΚΕΣ
… TO THE CHEST, WITH OR WITHOUT POST-RADIATION INDOMETHACIN ADMINISTRATION. THE RESULTS OF OUR STUDY REVEALED THE FOLLOWING: 1) INCREASING PULMONARY BLOOD FLOW LEVELS INCREASED PERFUSED MICROVASCULAR SURFACE AREA, AS REFLECTED IN THE PROPORTIONALLY INCREASING AMAX/KM OR BMAX VALUES FOR ALL …
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Adhesion and intercellular junction formation by pulmonary intravascular macrophages and endothelial cells in vitro
… by coculturing intravascular macrophages with indomethacin or pretreating intravascular macrophages with indomethacin before coculturing the cells with endothelium. Pretreatment of endothelial cells with indomethacin did not inhibit adherence of intravascular macrophages to endothelium. These …
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Evaluation of the antinociceptive, anti-inflammatory and antipyretic activities of Ruta Graveolens L. in mice and rats
… % inhibition of 3 % acetic acid-induced writhes. Indomethacin (20 mg/kg,i.p.) and paracetamol (500 mg/kg, i.p.) significantly reduced the number of 3 % acetic acidinduced writhes. Indomethacin (20 mg/kg, i.p.) and paracetamol (500 mg/kg, i.p.) produced 57 % and 80 % inhibition of 3 % acetic …
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Polymorph Selection with Morphology Control Using Solvents and Additives
… morphology and selectively isolate polymorphs. Indomethacin is known to exhibit at least five polymorphs but only the stable γ Form and metastable α Form are reported to be reliably produced by standard methods. The metastable α Form has an undesirable fibrous needle-like morphology. The current …
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ΣΥΜΒΟΛΗ ΣΤΗ ΜΕΛΕΤΗ ΤΗΣ ΠΕΡΙΕΚΤΙΚΟΤΗΤΑΣ ΣΕ ΚΑΛΛΙΚΡΕΙΝΗ ΤΟΥ ΟΛΙΚΟΥ ΣΙΑΛΟΥ ΤΟΥ ΑΝΘΡΩΠΟΥ IN VIVO ΚΑΙ ΤΩΝ ΥΠΟΓΝΑΘΙΩΝ ΑΔΕΝΩΝ ΤΩΝ ΕΠΙΜΥΩΝ IN VITRO ΜΕΤΑ ΤΗ ΧΟΡΗΓΗΣΗ ΑΝΤΙΦΛΕΓΜΟΝΩΔΩΝ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΟΥΣΙΩΝ.
… ADMINISTRATION OF TWO ANTINFLAMMATORY AGENTS (INDOMETHACIN, NIFLEUMIC ACID) AS WELL AS IN THE EXTRACTION OF THE SUBMANDIBULAR GLANDS OF 15 RATS AFTER THE ADMINISTRATION OF PHENYLBUTAZONE, DEXAMETHAZONE, INDOMETHACIN AND NIFLEUMIC ACID IN DIFFERENT MALARITIES. IN BOTH GROUPS THE RATES OF …
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Engineering of composite pharmaceuticals with improved physicochemical and mechanical properties
… composite particles of three drugs (paracetamol, indomethacin, and metformin hydrochloride), which are notoriously known for their poor tabletting and dissolution properties were prepared and investigated to improve their tabletting and dissolution properties. The tabletting deficiency of …
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Development of cocrystals of water insoluble active substances with inactive excipients by using hot melt extrusion
… examined in order to optimise the formation of indomethacin-saccharin cocrystals by using TSE. Important HME processing parameters-screw speed and extruder barrel temperature -were found to have an influence on the production of the cocrystals. Indomethacin-saccharin cocrystals improved the …
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A Study on the Modes of Action of Angiotensin on Isolated Smooth muscle Preparations
… biosynthesis inhibitors, aspirin and indomethacin, on angiotensin-induced contraction was examined in several smooth muscle preparations. Indomethacin selectively reduced angiotensin-induced contraction in all preparations used with the exception of the rat colon. Attempts were made to …
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