Μελέτη της κλινικής σημασίας της αγγειογένεσης σε ασθενείς με νόσο hodgkin

Angiogenesis has been recently implicated in the pathophy­siology and course of various hematologic malignancies. Its significance in Hodgkin’s lymphoma (HL), however, is not known. The purpose of the study was to evaluate various morphometric characteristics of microvessels, highlighted by means of anti-CD34 immunohistochemistry, in the lymph node of 286 patients with HL at diagnosis and investigate their relationship with several clinicopatho­logic parameters and prognosis. EXPERIMENTAL DESIGN: Microvessel density (MVD), total vascular area (TVA) and several size- and shape-related microvascular parameters were quantitated in the region of most intense vascularization using image analysis. RESULTS: An increase in microvessel caliber parameters (namely area, perimeter, major axis length and minor axis length) and a decrease in MVD was noted with increasing stage. An inverse relationship was similarly recorded between MVD and the number of involved anatomic sites or LDH ratio. In univariate analysis, overall disease-specific survival was adversely affected by MVD and TVA, whereas inferior failure-free survival was associated with the presence of more flattened vessel sections. Multivariate analysis disclosed that the extent of angiogenesis (MVD/TVA), age and the number of involved anatomic sites independently affected overall survival. Accordingly, failure-free survival was independently linked to the shape of micro­vessels and albumin levels or the number of involved anatomic sites. CONCLUSIONS: Our data support the view that angiogenesis in HL provides independent prognostic information, requiring the concomitant evaluation of quantitative and qualitative aspects of microvascular netword.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

2008

Authors dc:creator

• Θυμαρά, Ειρήνη
• Thymara, Irene

• Αγγειογένεση
• Λέμφωμα Hodgkin
• Αιματολογικές κακοήθειες
• Angiogenesis
• Hematological malignancy
• Lympoma Hodgkin
• Prognostic factors
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0780

OAI identifier oai:identifier

oai:10442/0780