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Showing 1 to 20 of 36 for “"hematologic malignancies"”.
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Trisomies in Hematologic Malignancies
… with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.., trisomies ? are also frequent. Little is known …
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Critical Illness in Patients with Hematologic Malignancies
Introduction: Patients with hematologic malignancy are at increased risk of developing life-threatening complications that can lead to admission to an Intensive Care Unit (ICU). Acute respiratory failure is the most frequent reason for ICU admission in these patients. Existing knowledge gaps in the …
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Computational Frameworks to Interpret Genetic Abnormalities in Hematologic Malignancies
… information from NGS data in the context of hematologic malignancies. First, I show how incorporating allelic burdens of mutations can enhance the risk stratification of patients with acute myeloid leukemia (AML). Instead of considering mutations as binary variables, the model considers …
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Modeling hematologic malignancies and their treatment in humanized mice
… of adult human stem cells permits modeling of hematologic malignancies in human cells. To that end, a lentiviral vector capable of stoichiometric expression of up to three transgenes in a B cell-specific manner was constructed; in this case, these transgenes included the GFP reporter and the …
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EXPLORING THE MUTATIONAL LANDSCAPE OF MITOCHONDRIAL GENOME IN HEMATOLOGIC MALIGNANCIES
… in carcinogenesis, their contribution to hematologic malignancies remains insufficiently understood, particularly with respect to low-level heteroplasmic variants. In this study, we analyzed 728 whole-genome and whole-exome sequencing samples from patients with diffuse large B-cell …
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Orthogonal Comparison of Nuclear and Mitochondrial Clonal Architectures in Hematologic Malignancies
<p>Acute myeloid leukemia (AML) is a hematologic malignancy characterized by accumulation of mutations that disrupt hematopoietic differentiation and promote clonal expansion. Understanding how these mutations arise and evolve is essential for improving diagnosis, prognosis, and treatment …
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Patient Attitudes to ward Genetic Testing For Inherited Predispositions to Hematologic Malignancies
<p>Although inherited predispositions to hematologic malignancies have previously been considered extremely rare, approximately 12 causative genes have been implicated in the last decade. Since individuals diagnosed with leukemia have not historically been considered for evaluation of inherited …
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Clinical Applicability of Proposed Algorithm For Identifying Individuals At Risk For Hereditary Hematologic Malignancies
… to cause hereditary predispositions to hematologic malignancies. These syndromes are characterized by an increased risk to develop myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), or aplastic anemia (AA) at young ages, with various phenotypic features including peripheral …
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Spectrum and Incidence of Primary and Therapy-Related Hematologic Malignancies In Individuals With Brca1 and Brca2 Pathogenic Variants
… myeloid neoplasms (t-MN) are rare and deadly hematologic malignancies that develop following exposure to cytotoxic therapies such as radiation, chemotherapy, and poly (adenosine diphosphate-ribose)-ADP polymerase (PARP) inhibitors. Preliminary evidence suggests that germline <em>BRCA1</em> and …
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Ex Vivo Expanded Cord Blood Natural Killer Cells As A Novel Therapeutic For Multiple Myeloma
… myeloma (MM) is the second most common hematologic malignancy in adults and, to date, is incurable. Allogeneic natural killer (NK) cells are active in various hematologic malignancies and may have a role against MM. Umbilical cord blood is a potential source for allogeneic NK cells and …
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Μελέτη της κλινικής σημασίας της αγγειογένεσης σε ασθενείς με νόσο hodgkin
… in the pathophysiology and course of various hematologic malignancies. Its significance in Hodgkin’s lymphoma (HL), however, is not known. The purpose of the study was to evaluate various morphometric characteristics of microvessels, highlighted by means of anti-CD34 immunohistochemistry, in …
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An integrative bioinformatics approach to characterize molecular landscapes and clinical outcomes in acute leukemias
… are biologically and clinically heterogeneous hematologic malignancies. This dissertation examines this heterogeneity at three levels: population-based disease patterns, RNA-seq-based molecular classification, and developmental interpretation. First, nationwide German cancer registry data were …
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An Investigation into the Potential of Cell Therapies for Acute Myeloid Leukemia (AML) Treatment
… Cell therapies have shown great success against hematologic malignancies but face several challenges including treatment-related toxicities and human-leukocyte antigen (HLA) matching. Natural killer (NK) cells and gamma delta (γδ) T cells offer alternative effector cell options for cell therapies …
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Investigating The Role of Il-10 Producing Nkt Cells In Prevention of Graft Versus Host Disease
<p>The standard curative treatment for hematologic malignancies is allogeneic stem cell transplantation (ASCT), in which the patient’s immune system is replaced with that of a healthy donor. This can lead to cure through the graft versus leukemia (GVL) effect but can also cause graft versus host …
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Fc Gamma Receptors Facilitate Antigenic Modulation of LILRB4 and Function as Predictive Biomarkers in Acute Monocytic Leukemia
… of anti-CD20 antibodies targeting B cell malignancies.</p> <p>Through this Fc-mediated mechanism, the anti-LILRB4 mAb and others bind their target receptor, inducing internalization of the antigen complex. In the case of anti-LILRB4, this antigenic modulation mechanism leads to improved …
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Role of S6K1 in regulating self-renewal of hematopoietic stem cells and propagatoin of leukemia
… function and contributes to the development of hematologic malignancies. Activated mTORC1 phosphorylates and subsequently activates ribosomal protein S6 kinase 1 (S6K1). To study the role of S6K1 in hematopoiesis as well as leukemogenesis, we used a genetic model of S6K1 deficient mice …
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Retroviral-mediated gene transfer of Il-1β?cDNA into human activated T cells
… in refractory cancer patients who suffer from hematologic malignancies or solid tumors. ATC are readily generated from peripheral blood and possess non-major histocompatibility complex (non-MHC) restricted killing properties. ATC are also powerful targets for genetic modification and hold …
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Genetic and Clinical Determinants of Racial/Ethnic Differences In Multiple Myeloma Susceptibility and Outcomes Focusing On Hispanics
… Myeloma (MM) constitutes 10% of diagnosed hematologic malignancies in the US, with over 12,000 deaths recorded each year. Race/ethnicity is a well-known MM risk factor, where individuals of African descent have over 2- to 3-fold increased risk of incidence compared to those of European …
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Targeted Multistage Delivery of Nanoparticles to The Bone Marrow
… including myeloproliferative disorders and hematologic malignancies and metastases from breast and prostate. Most of these diseases are characterized with poor quality of life, and the treatment options are only palliative due to lack of delivery mechanisms for systemically injected drugs …
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The Regulation Of Myeloid Inflammatory Responses By Runx1: Roles In Normal And Malignant Hematopoiesis
… mutated in sporadic and inherited forms of hematologic malignancies, but the mechanism underlying it role in leukemogenesis remains poorly defined. In the first part of this work, we describe a novel role for RUNX1 in regulating TLR1/2 and TLR4 signaling and inflammatory cytokine production …
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