Η ΕΠΙΔΡΑΣΗ ΤΟΥ ΣΥΜΠΛΟΚΟΥ ΔΕΞΑΜΕΘΑΖΟΝΗΣ-ΥΠΟΔΟΧΕΑ ΣΤΗΝ IN VITRO RNA ΣΥΝΘΕΣΗ ΑΠΟΜΟΝΩΜΕΝΩΝ ΠΥΡΗΝΩΝ ΘΥΜΟΥ ΚΑΙ ΣΥΚΩΤΙΟΥ ΑΡΟΥΡΑΙΟΥ

GLUCOCORTICOIDS ACT IN THE TARGET ORGANS THROUGH SPECIFIC RECEPTORS AND ELICIT SUCH BIOLOGICAL EFFECTS AS THE MODULATION OF THE RNA SYNTHESIS WHICH IS EXPRESSED AS INHIBITION IN THYMUS (FINAL RESULT IS DEATH) AND INCREASE IN LIVER. THE CELL DEATH OF THYMOCYTE POPULATIONS CAUSED BY DEXAMETHASONE WAS STUDIED IN IN VITRO SYSTEMS. WE ALSO STUDIED THE DIFFERENTIAL ACTION OF THE DEXAMETHASONE RECEPTOR COMPLEX IN THYMUS AND LIVER BY MEASURING THE RNA SYNTHESIS OF NUCLEI IN A RECONSTITUTED IN VITRO SYSTEM WITH ISOLATED NUCLEI AND ISOLATED DE-1 AND DE-2 COMPLEX FORMS IN HOMOLOGOUS AND HETEROLOGOUS REACTIONS. THE HOMOLOGOUS REACTIONS CONFIRM THE IN VIVO EFFECT, SUCH AS INHIBITION IN THE THYMUS AND INCREASE OF THE RNA SYNTHESIS IN THE LIVER. IN THE HETEROLOGOUS REACTIONS AN INHIBITION OF THE RNA SYNTHESIS IS OBTAINED. WE SUGGEST THAT THE CORRESPONDING EFFECT OF THE HORMONE ACTION IN LIVER OR THYMUS TWO ELEMENTS ARE INVOLVED: THE RECEPTOR COMPLEXPER SE AND THE ORIGIN OF THE NUCLEUS.

Grantor dc:publisher

Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

Year dc:date

1987

Author dc:creator

• Τζαβάρας, Θεόδωρος

• DEXAMETHASONE RECEPTOR
• ISOLATED RAT THYMUS AND LIVER NUCLEI
• REGULATION OF RNA SYNTHESIS IN VITRO
• Tyrosine aminotransferase
• Αμινοτρανσφεράση της τυροσίνης
• ΡΥΘΜΙΣΗ RNA ΣΥΝΘΕΣΗΣ IN VITRO
• ΥΠΟΔΟΧΕΑΣ ΔΕΞΑΜΕΘΑΖΟΝΗΣ
• Natural Sciences
• Biological Sciences
• Φυσικές Επιστήμες
• Βιολογία

Language dc:language

gre

Identifier

10.12681/eadd/0698

OAI identifier oai:identifier

oai:10442/0698