{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0698"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0698","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"Η ΕΠΙΔΡΑΣΗ ΤΟΥ ΣΥΜΠΛΟΚΟΥ ΔΕΞΑΜΕΘΑΖΟΝΗΣ-ΥΠΟΔΟΧΕΑ ΣΤΗΝ IN VITRO RNA ΣΥΝΘΕΣΗ ΑΠΟΜΟΝΩΜΕΝΩΝ ΠΥΡΗΝΩΝ ΘΥΜΟΥ ΚΑΙ ΣΥΚΩΤΙΟΥ ΑΡΟΥΡΑΙΟΥ","abstract":"GLUCOCORTICOIDS ACT IN THE TARGET ORGANS THROUGH SPECIFIC RECEPTORS AND ELICIT SUCH BIOLOGICAL EFFECTS AS THE MODULATION OF THE RNA SYNTHESIS WHICH IS EXPRESSED AS INHIBITION IN THYMUS (FINAL RESULT IS DEATH) AND INCREASE IN LIVER. THE CELL DEATH OF THYMOCYTE POPULATIONS CAUSED BY DEXAMETHASONE WAS STUDIED IN IN VITRO SYSTEMS. WE ALSO STUDIED THE DIFFERENTIAL ACTION OF THE DEXAMETHASONE RECEPTOR COMPLEX IN THYMUS AND LIVER BY MEASURING THE RNA SYNTHESIS OF NUCLEI IN A RECONSTITUTED IN VITRO SYSTEM WITH ISOLATED NUCLEI AND ISOLATED DE-1 AND DE-2 COMPLEX FORMS IN HOMOLOGOUS AND HETEROLOGOUS REACTIONS. THE HOMOLOGOUS REACTIONS CONFIRM THE IN VIVO EFFECT, SUCH AS INHIBITION IN THE THYMUS AND INCREASE OF THE RNA SYNTHESIS IN THE LIVER. IN THE HETEROLOGOUS REACTIONS AN INHIBITION OF THE RNA SYNTHESIS IS OBTAINED. WE SUGGEST THAT THE CORRESPONDING EFFECT OF THE HORMONE ACTION IN LIVER OR THYMUS TWO ELEMENTS ARE INVOLVED: THE RECEPTOR COMPLEXPER SE AND THE ORIGIN OF THE NUCLEUS.","abstract_html":"GLUCOCORTICOIDS ACT IN THE TARGET ORGANS THROUGH SPECIFIC RECEPTORS AND ELICIT SUCH BIOLOGICAL EFFECTS AS THE MODULATION OF THE RNA SYNTHESIS WHICH IS EXPRESSED AS INHIBITION IN THYMUS (FINAL RESULT IS DEATH) AND INCREASE IN LIVER. THE CELL DEATH OF THYMOCYTE POPULATIONS CAUSED BY DEXAMETHASONE WAS STUDIED IN IN VITRO SYSTEMS. WE ALSO STUDIED THE DIFFERENTIAL ACTION OF THE DEXAMETHASONE RECEPTOR COMPLEX IN THYMUS AND LIVER BY MEASURING THE RNA SYNTHESIS OF NUCLEI IN A RECONSTITUTED IN VITRO SYSTEM WITH ISOLATED NUCLEI AND ISOLATED DE-1 AND DE-2 COMPLEX FORMS IN HOMOLOGOUS AND HETEROLOGOUS REACTIONS. THE HOMOLOGOUS REACTIONS CONFIRM THE IN VIVO EFFECT, SUCH AS INHIBITION IN THE THYMUS AND INCREASE OF THE RNA SYNTHESIS IN THE LIVER. IN THE HETEROLOGOUS REACTIONS AN INHIBITION OF THE RNA SYNTHESIS IS OBTAINED. WE SUGGEST THAT THE CORRESPONDING EFFECT OF THE HORMONE ACTION IN LIVER OR THYMUS TWO ELEMENTS ARE INVOLVED: THE RECEPTOR COMPLEXPER SE AND THE ORIGIN OF THE NUCLEUS.","abstract_has_math":false,"creators":["Τζαβάρας, Θεόδωρος"],"institution":"Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1987,"date_issued":"1987","date_published":"1987","updated_at":"2026-07-24T02:25:24Z","subjects":["DEXAMETHASONE RECEPTOR","ISOLATED RAT THYMUS AND LIVER NUCLEI","REGULATION OF RNA SYNTHESIS IN VITRO","Tyrosine aminotransferase","Αμινοτρανσφεράση της τυροσίνης","ΡΥΘΜΙΣΗ RNA ΣΥΝΘΕΣΗΣ IN VITRO","ΥΠΟΔΟΧΕΑΣ ΔΕΞΑΜΕΘΑΖΟΝΗΣ","Natural Sciences","Biological Sciences","Φυσικές Επιστήμες","Βιολογία"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0698"],"render_values":[{"text":"10.12681/eadd/0698","href":"https://doi.org/10.12681/eadd/0698","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0698","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Τζαβάρας, Θεόδωρος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1987"]},{"key":"dc:publisher","label":"Institution","values":["Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)","National and Kapodistrian University of Athens"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["DEXAMETHASONE RECEPTOR","ISOLATED RAT THYMUS AND LIVER NUCLEI","REGULATION OF RNA SYNTHESIS IN VITRO","Tyrosine aminotransferase","Αμινοτρανσφεράση της τυροσίνης","ΡΥΘΜΙΣΗ RNA ΣΥΝΘΕΣΗΣ IN VITRO","ΥΠΟΔΟΧΕΑΣ ΔΕΞΑΜΕΘΑΖΟΝΗΣ","Natural Sciences","Biological Sciences","Φυσικές Επιστήμες","Βιολογία"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0698","http://hdl.handle.net/10442/hedi/0698"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["GLUCOCORTICOIDS ACT IN THE TARGET ORGANS THROUGH SPECIFIC RECEPTORS AND ELICIT SUCH BIOLOGICAL EFFECTS AS THE MODULATION OF THE RNA SYNTHESIS WHICH IS EXPRESSED AS INHIBITION IN THYMUS (FINAL RESULT IS DEATH) AND INCREASE IN LIVER. THE CELL DEATH OF THYMOCYTE POPULATIONS CAUSED BY DEXAMETHASONE WAS STUDIED IN IN VITRO SYSTEMS. WE ALSO STUDIED THE DIFFERENTIAL ACTION OF THE DEXAMETHASONE RECEPTOR COMPLEX IN THYMUS AND LIVER BY MEASURING THE RNA SYNTHESIS OF NUCLEI IN A RECONSTITUTED IN VITRO SYSTEM WITH ISOLATED NUCLEI AND ISOLATED DE-1 AND DE-2 COMPLEX FORMS IN HOMOLOGOUS AND HETEROLOGOUS REACTIONS. THE HOMOLOGOUS REACTIONS CONFIRM THE IN VIVO EFFECT, SUCH AS INHIBITION IN THE THYMUS AND INCREASE OF THE RNA SYNTHESIS IN THE LIVER. IN THE HETEROLOGOUS REACTIONS AN INHIBITION OF THE RNA SYNTHESIS IS OBTAINED. WE SUGGEST THAT THE CORRESPONDING EFFECT OF THE HORMONE ACTION IN LIVER OR THYMUS TWO ELEMENTS ARE INVOLVED: THE RECEPTOR COMPLEXPER SE AND THE ORIGIN OF THE NUCLEUS.","ΤΑ ΓΛΥΚΟΚΟΡΤΙΚΟΕΙΔΗ ΔΡΟΥΝ ΣΤΑ ΟΡΓΑΝΑ-ΣΤΟΧΟΥΣ ΜΕΣΩ ΕΙΔΙΚΩΝ ΥΠΟΔΟΧΕΩΝ ΚΑΙ ΕΠΙΦΕΡΟΥΝ ΒΙΟΛΟΓΙΚΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΠΟΥ ΜΕΤΑΞΥ ΑΛΛΩΝ ΕΙΝΑΙ ΚΑΙ Η ΜΕΤΑΒΟΛΗ ΤΗΣ RNA ΣΥΝΘΕΣΗΣ ΠΟΥ ΕΚΦΡΑΖΕΤΑΙ ΣΑΝ ΑΝΑΣΤΟΛΗ ΣΤΟ ΘΥΜΟ (ΜΕ ΤΕΛΙΚΟ ΑΠΟΤΕΛΕΣΜΑ ΤΟ ΘΑΝΑΤΟ) ΚΑΙ ΑΥΞΗΣΗ ΣΤΟ ΣΥΚΩΤΙ. ΜΕΛΕΤΗΘΗΚΕ Ο ΘΥΜΟΚΥΤΤΑΡΙΚΟΣ ΘΑΝΑΤΟΣ ΠΛΗΘΥΣΜΩΝ ΘΥΜΟΥ ΣΤΗΝ ΔΡΑΣΗ ΤΗΣ ΔΕΞΑΜΕΘΑΖΟΝΗΣ ΣΕ IN VITRO ΣΥΣΤΗΜΑΤΑ. ΕΠΙΣΗΣ ΜΕΛΕΤΗΘΗΚΕ Η ΔΙΑΦΟΡΙΚΗ ΔΡΑΣΗ ΤΟΥ ΣΥΜΠΛΟΚΟΥ ΔΕΞΑΜΕΘΑΖΟΝΗΣ-ΥΠΟΔΟΧΕΑ ΣΕ ΘΥΜΟ ΚΑΙ ΣΥΚΩΤΙ ΜΕΤΡΩΝΤΑΣ ΤΗΝ RNA ΣΥΝΘΕΣΗΠΥΡΗΝΩΝ ΣΕ ΑΝΑΣΥΓΚΡΟΤΟΥΜΕΝΟ ΣΥΣΤΗΜΑ IN VITRO ΜΕ ΑΠΟΜΟΝΩΜΕΝΟΥΣ ΠΥΡΗΝΕΣ ΚΑΙ ΑΠΟΜΟΝΩΜΕΝΕΣ ΜΟΡΦΕΣ DE-1, DE-2 ΣΥΜΠΛΟΚΟΥ ΜΕ ΟΜΟΛΟΓΕΣ ΚΑΙ ΣΤΑΥΡΩΤΕΣ ΑΝΤΙΔΡΑΣΕΙΣ. ΣΤΙΣ ΟΜΟΛΟΓΕΣ ΑΝΤΙΔΡΑΣΕΙΣ ΕΠΙΒΕΒΑΙΩΝΟΝΤΑΙ ΤΑ IN VITRO ΑΠΟΤΕΛΕΣΜΑΤΑ ΗΤΟΙ ΑΝΑΣΤΟΛΗ ΤΗΣ RNA ΣΥΝΘΕΣΗΣ ΣΤΟ ΘΥΜΟ ΚΑΙ ΑΥΞΗΣΗ ΣΤΟ ΘΥΜΟ ΚΑΙ ΑΥΞΗΣΗ ΣΤΟ ΣΥΚΩΤΙ. ΣΤΙΣ ΣΤΑΥΡΩΤΕΣ ΕΜΦΑΝΙΖΕΤΑΙ ΑΝΑΣΤΟΛΗ ΤΗΣ RNA ΣΥΝΘΕΣΗΣ. ΠΡΟΤΕΙΝΕΤΑΙ ΟΤΙ ΣΤΟ ΑΝΑΛΟΓΟ ΑΠΟΤΕΛΕΣΜΑΤΑ ΤΗΣ ΔΡΑΣΗΣ ΤΟΥ ΣΥΜΠΛΟΚΟΥ ΣΕ ΘΥΜΟ/ΣΥΚΩΤΙ ΣΥΜΜΕΤΕΧΟΥΝ ΤΟΣΟ ΤΟ ΣΥΜΠΛΟΚΟ ΑΥΤΟ ΚΑΘΕΑΥΤΟ ΟΣΟ ΚΑΙ Ο ΠΥΡΗΝΑΣ ΤΟΥ ΔΕΔΟΜΕΝΟΥ ΟΡΓΑΝΟΥ."]},{"key":"dc:title","label":"Title","values":["Η ΕΠΙΔΡΑΣΗ ΤΟΥ ΣΥΜΠΛΟΚΟΥ ΔΕΞΑΜΕΘΑΖΟΝΗΣ-ΥΠΟΔΟΧΕΑ ΣΤΗΝ IN VITRO RNA ΣΥΝΘΕΣΗ ΑΠΟΜΟΝΩΜΕΝΩΝ ΠΥΡΗΝΩΝ ΘΥΜΟΥ ΚΑΙ ΣΥΚΩΤΙΟΥ ΑΡΟΥΡΑΙΟΥ","THE EFFECT OF THE DEXAMETHASONE-RECEPTOR COMPLEX ON THE IN VITRO RNA SYNTHESIS OF ISOLATED NUCLEI FROM RAT THYMUS AND LIVER"]}]}],"canonical_facts":{"dc:creator":["Τζαβάρας, Θεόδωρος"],"dc:date":["1987"],"dc:description":["GLUCOCORTICOIDS ACT IN THE TARGET ORGANS THROUGH SPECIFIC RECEPTORS AND ELICIT SUCH BIOLOGICAL EFFECTS AS THE MODULATION OF THE RNA SYNTHESIS WHICH IS EXPRESSED AS INHIBITION IN THYMUS (FINAL RESULT IS DEATH) AND INCREASE IN LIVER. THE CELL DEATH OF THYMOCYTE POPULATIONS CAUSED BY DEXAMETHASONE WAS STUDIED IN IN VITRO SYSTEMS. WE ALSO STUDIED THE DIFFERENTIAL ACTION OF THE DEXAMETHASONE RECEPTOR COMPLEX IN THYMUS AND LIVER BY MEASURING THE RNA SYNTHESIS OF NUCLEI IN A RECONSTITUTED IN VITRO SYSTEM WITH ISOLATED NUCLEI AND ISOLATED DE-1 AND DE-2 COMPLEX FORMS IN HOMOLOGOUS AND HETEROLOGOUS REACTIONS. THE HOMOLOGOUS REACTIONS CONFIRM THE IN VIVO EFFECT, SUCH AS INHIBITION IN THE THYMUS AND INCREASE OF THE RNA SYNTHESIS IN THE LIVER. IN THE HETEROLOGOUS REACTIONS AN INHIBITION OF THE RNA SYNTHESIS IS OBTAINED. WE SUGGEST THAT THE CORRESPONDING EFFECT OF THE HORMONE ACTION IN LIVER OR THYMUS TWO ELEMENTS ARE INVOLVED: THE RECEPTOR COMPLEXPER SE AND THE ORIGIN OF THE NUCLEUS.","ΤΑ ΓΛΥΚΟΚΟΡΤΙΚΟΕΙΔΗ ΔΡΟΥΝ ΣΤΑ ΟΡΓΑΝΑ-ΣΤΟΧΟΥΣ ΜΕΣΩ ΕΙΔΙΚΩΝ ΥΠΟΔΟΧΕΩΝ ΚΑΙ ΕΠΙΦΕΡΟΥΝ ΒΙΟΛΟΓΙΚΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΠΟΥ ΜΕΤΑΞΥ ΑΛΛΩΝ ΕΙΝΑΙ ΚΑΙ Η ΜΕΤΑΒΟΛΗ ΤΗΣ RNA ΣΥΝΘΕΣΗΣ ΠΟΥ ΕΚΦΡΑΖΕΤΑΙ ΣΑΝ ΑΝΑΣΤΟΛΗ ΣΤΟ ΘΥΜΟ (ΜΕ ΤΕΛΙΚΟ ΑΠΟΤΕΛΕΣΜΑ ΤΟ ΘΑΝΑΤΟ) ΚΑΙ ΑΥΞΗΣΗ ΣΤΟ ΣΥΚΩΤΙ. ΜΕΛΕΤΗΘΗΚΕ Ο ΘΥΜΟΚΥΤΤΑΡΙΚΟΣ ΘΑΝΑΤΟΣ ΠΛΗΘΥΣΜΩΝ ΘΥΜΟΥ ΣΤΗΝ ΔΡΑΣΗ ΤΗΣ ΔΕΞΑΜΕΘΑΖΟΝΗΣ ΣΕ IN VITRO ΣΥΣΤΗΜΑΤΑ. ΕΠΙΣΗΣ ΜΕΛΕΤΗΘΗΚΕ Η ΔΙΑΦΟΡΙΚΗ ΔΡΑΣΗ ΤΟΥ ΣΥΜΠΛΟΚΟΥ ΔΕΞΑΜΕΘΑΖΟΝΗΣ-ΥΠΟΔΟΧΕΑ ΣΕ ΘΥΜΟ ΚΑΙ ΣΥΚΩΤΙ ΜΕΤΡΩΝΤΑΣ ΤΗΝ RNA ΣΥΝΘΕΣΗΠΥΡΗΝΩΝ ΣΕ ΑΝΑΣΥΓΚΡΟΤΟΥΜΕΝΟ ΣΥΣΤΗΜΑ IN VITRO ΜΕ ΑΠΟΜΟΝΩΜΕΝΟΥΣ ΠΥΡΗΝΕΣ ΚΑΙ ΑΠΟΜΟΝΩΜΕΝΕΣ ΜΟΡΦΕΣ DE-1, DE-2 ΣΥΜΠΛΟΚΟΥ ΜΕ ΟΜΟΛΟΓΕΣ ΚΑΙ ΣΤΑΥΡΩΤΕΣ ΑΝΤΙΔΡΑΣΕΙΣ. ΣΤΙΣ ΟΜΟΛΟΓΕΣ ΑΝΤΙΔΡΑΣΕΙΣ ΕΠΙΒΕΒΑΙΩΝΟΝΤΑΙ ΤΑ IN VITRO ΑΠΟΤΕΛΕΣΜΑΤΑ ΗΤΟΙ ΑΝΑΣΤΟΛΗ ΤΗΣ RNA ΣΥΝΘΕΣΗΣ ΣΤΟ ΘΥΜΟ ΚΑΙ ΑΥΞΗΣΗ ΣΤΟ ΘΥΜΟ ΚΑΙ ΑΥΞΗΣΗ ΣΤΟ ΣΥΚΩΤΙ. ΣΤΙΣ ΣΤΑΥΡΩΤΕΣ ΕΜΦΑΝΙΖΕΤΑΙ ΑΝΑΣΤΟΛΗ ΤΗΣ RNA ΣΥΝΘΕΣΗΣ. ΠΡΟΤΕΙΝΕΤΑΙ ΟΤΙ ΣΤΟ ΑΝΑΛΟΓΟ ΑΠΟΤΕΛΕΣΜΑΤΑ ΤΗΣ ΔΡΑΣΗΣ ΤΟΥ ΣΥΜΠΛΟΚΟΥ ΣΕ ΘΥΜΟ/ΣΥΚΩΤΙ ΣΥΜΜΕΤΕΧΟΥΝ ΤΟΣΟ ΤΟ ΣΥΜΠΛΟΚΟ ΑΥΤΟ ΚΑΘΕΑΥΤΟ ΟΣΟ ΚΑΙ Ο ΠΥΡΗΝΑΣ ΤΟΥ ΔΕΔΟΜΕΝΟΥ ΟΡΓΑΝΟΥ."],"dc:identifier":["10.12681/eadd/0698","http://hdl.handle.net/10442/hedi/0698"],"dc:language":["gre"],"dc:publisher":["Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)","National and Kapodistrian University of Athens"],"dc:subject":["DEXAMETHASONE RECEPTOR","ISOLATED RAT THYMUS AND LIVER NUCLEI","REGULATION OF RNA SYNTHESIS IN VITRO","Tyrosine aminotransferase","Αμινοτρανσφεράση της τυροσίνης","ΡΥΘΜΙΣΗ RNA ΣΥΝΘΕΣΗΣ IN VITRO","ΥΠΟΔΟΧΕΑΣ ΔΕΞΑΜΕΘΑΖΟΝΗΣ","Natural Sciences","Biological Sciences","Φυσικές Επιστήμες","Βιολογία"],"dc:title":["Η ΕΠΙΔΡΑΣΗ ΤΟΥ ΣΥΜΠΛΟΚΟΥ ΔΕΞΑΜΕΘΑΖΟΝΗΣ-ΥΠΟΔΟΧΕΑ ΣΤΗΝ IN VITRO RNA ΣΥΝΘΕΣΗ ΑΠΟΜΟΝΩΜΕΝΩΝ ΠΥΡΗΝΩΝ ΘΥΜΟΥ ΚΑΙ ΣΥΚΩΤΙΟΥ ΑΡΟΥΡΑΙΟΥ","THE EFFECT OF THE DEXAMETHASONE-RECEPTOR COMPLEX ON THE IN VITRO RNA SYNTHESIS OF ISOLATED NUCLEI FROM RAT THYMUS AND LIVER"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:24Z"}