ΑΝΟΣΟΙΣΤΟΧΗΜΙΚΗ ΑΝΙΧΝΕΥΣΗ ΥΠΟΔΟΧΕΩΝ ΟΙΣΤΡΟΓΟΝΩΝ ΣΕ ΚΑΡΚΙΝΟ ΤΟΥ ΜΑΣΤΟΥ. ΣΥΓΚΡΙΤΙΚΗ ΜΕΛΕΤΗ

RECEPTORS BOUND IN VIVO WITH ESTROGENS WERE DETECTED IMMUNOHISTOCHEMICALLY (PAPMETHOD) IN PARAFI SECTIONS OF 68 PRIMARY MAMMARY CARCINOMAS BY USING AS PRIMARY ANTISERUM RABBIT ANTI-17 BETA ESTRADIOL-BSA AND WITHOUT PREVIOUS INCUBATION OF THE SECTIONS WITH EXOGENOUS ESTROGEN. ALL CASES WERE ALSO BIOCHEMICALLY TESTED FOR ER BY USING DCC METHOD. THE PRESENT IMMUNOHISTOCHEMICAL METHOD IS RELIABLE AND CAN BE EASILY PERFORMED WITHOUT SOPHISTICATED EQUIPMENT. THIS METHOD, ALONE AND ESPECIALLY IN COMBINATION WITH OTHER BIOCHEMICAL AND/OR IMMUNOHISTOCHEMICAL METHODS, CAN BE USED FOR THE EFFECTIVE DETECTION OF THE ER CONTENT IN MAMMARY CARCINOMAS. IT IS FOR THE FIRST TIME USED IN A EUROPEAN COUNTRY WITH A HIGH PERCENTAGE OF POSITIVE CASES AND A STATISTICALLY SIGNIFICANT AGREEMENT OF ITS RESULTS TO THOSE OF THE DCC METHOD. A HETEROGENICITY OF NEOPLASTIC CELLS TO THE POSITIVITY FOR ER WAS SHOWN. IT WAS ALSO SHOWN A POSITIVE CORRELATION BETWEEN THE ER CONTENT AND THE CELLULARITY OF THE TUMOURS, THE AGE OR THE MENOPAUSAL STATUS OF THE PATIENTS AND OBESITY. LYMPH NODAL METASTASES SHOWED THE SAME IMMUNOHISTOCHEMICAL PICTURE OF ER WITH THE PRIMARY TUMOURS. LATER METASTASES WERE, HOWEVER, IN THEIR MAJORITY NEGATIVE FOR ER BOTH IMMUNOHISTOCHEMICALLY AND BIOCHEMICALLY.

Grantor dc:publisher

University of Ioannina

Year dc:date

1987

Authors dc:creator

• Kaloutsi, Vassiliki
• Καλούτση, Βασιλική

• Ανοσοϊστοχημεία
• Ιστολογία
• Καρκίνος μαστού
• Υποδοχείς οιστρογόνων
• Breast cancer
• Estrogen receptors
• Histology
• Immunohistochemistry ( IHC)
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0483

OAI identifier oai:identifier

oai:10442/0483