Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 78 for “"DCC"”.
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Molecular biology of peripheral nerve regeneration: Expression and role of Netrin-1, DCC and Runx2
… its receptor - deleted in colorectal carcinoma (DCC). To study the role of DCC in peripheral nerve injury and repair, I generated a global knockout of DCC in adult mice using a Tamoxifen inducible Cre recombinase system. A transection injury in DCC global knockout mice revealed aberrant …
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Netrin Guides Spinal Commissural Axons to the Midline at Long Range Through the Receptors Dcc and Neogenin
… the differential roles for Netrin-1 receptors, Dcc and Neo1. How these two Netrin receptors collaborate during midline crossing has yet to be fully examined. Using transgenic embryos that express Cre-recombinase within discrete spinal interneuron populations in combination with fluorescent …
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The Intracellular Domain of the Frazzled/Dcc Receptor is a Transcription Factor Required for Commissural Axon Guidance
… guidance receptor Deleted in Colorectal Cancer (DCC), functions as a transcription factor to control axon responsiveness to the embryonic ventral midline. In Chapter 1, I introduce the embryonic ventral midline as a model system for studying how axons modulate their responsiveness to guidance …
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Signal Transduction Mechanisms in Commissural Axon Guidance: The Role of Intracellular Tyrosine Kinases in Netrin-Dcc/Frazzled Axon Attraction
… symmetric animals studied to date through the DCC family of receptors. In Drosophila, commissural neurons require Netrin and its DCC receptor, Frazzled, for midline axon crossing. To identify genes that function in Netrin signal transduction in vivo, we have taken two approaches: (1) a …
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Synthetic and mechanistic studies to expand the scope of alkyne metathesis dynamic covalent chemistry
Dynamic covalent chemistry (DCC) is a widely applied method for the synthesis of diverse molecular architectures and chemical libraries which are of broad interest in a number of chemical disciplines. As part of the greater subset of molecular self-assembly processes, DCC allows for the assembly of …
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Decellularized cartilage as a chondroinductive material for cartilage tissue engineering
… develop and evaluate decellularized cartilage (DCC) as a chondroinductive material for cartilage tissue engineering applications. This work was successful in developing a decellularization method for hyaline cartilage fragments that removed 99% of cells, while retaining 87% of GAGs and also in …
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Band to Band Calibration and Relative Gain Analysis of Satellite Sensors Using Deep Convective Clouds
… Landsat 8 using SCIAMACHY Deep Convective Cloud (DCC) spectra. Second, a novel method to derive relative gains using DCCs and improve the image quality of cirrus band scenes was developed. DCCs are very cold, bright clouds located in the tropopause layer. At small sun elevation and sensor viewing …
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On modelling volatility and mortality for pension schemes
… study of various advance multivariate DCC GARCH models which are used for construction of optimal portfolios in modelling asset return covariances. The effectiveness of using parametric copula in estimating portfolio risk measures are evaluated such that the DCC models are found to have …
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User interface design and evaluation of a shipboard electronic warfare console
… of the AN/SLQ-32(V) Display Control Console (DCC). The DCC provides Navy operators with bearing and threat information for radar emitters. The task of emitter identification was used to test potential redesigns. There is no research to substantiate the current or possible redesign solutions. …
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A dynamic optimal control system for complex compressed air networks
… solution. The Dynamic Compressor Controller (DCC) discussed in this thesis solves this problem. The DCC accomplishes this by calculating multiple compressed air set points - one for each individual compressor. These set points take the location and demand of the compressed air network into …
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Investigation of the roX RNAs and the RNA Helicase MLE in Dosage Compensation in Drosophila melanogaster
… is mediated by the dosage compensation complex (DCC), which is assembled in a sequential manner on the male X chromosome and is composed of the two noncoding roX (RNA on the X) RNAs and at least five proteins, including the RNA helicase Maleless (MLE). MLE contains two highly conserved double …
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Understanding reaction pathways leading to tetrahedral organic cages via alkyne metathesis
… POCs via multitopic dynamic covalent chemistry (DCC) has been demonstrated. The common view of successful DCC syntheses is that they proceed reversibly, ultimately allowing “error-correction” to provide thermodynamically favored products. The current approach to synthesize molecular cages is to …
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Sema-1a Reverse Signaling Promotes Midline Crossing In Response To Secreted Semaphorins
… part on the highly conserved guidance receptor DCC, or Frazzled in Drosophila, which signals chemoattraction upon binding its ligand, Netrin. DCC mutations in humans are associated with mirror movement disorder, an inability to independently control the right and left sides of the body. Although …
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The role of Ena/VASP and associated proteins in regulation of neuronal morphology and filopodia architecture
… the axon guidance cue Netrin-1 and its receptor DCC. I have shown Trim9 binds the cytoplasmic tail of DCC and also binds Ena/VASP proteins and Myosin-X, which are cytoskeletal effectors downstream of Netrin-1. I discovered that inhibition of Trim9 ubiquitin ligase activity specifically blocks …
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Respiratory Tract Infections: Aspects of Aetiology, Virulence, and Communicable Disease Control
… pneumococci are facilitated in day care centres (DCCs), which constitute an optimal environment for these processes. In Sweden, penicillin non-susceptible pneumococci (PNSP) have remained relatively uncommon,an important aspect considering that penicillin is the drug of choice for respiratory …
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Development and application of optical microscopy tools for the study of axon guidance
… cue receptors deleted in colorectal cancer (DCC) and neuropilin-1 (Nrp1) with the translation machinery. This interaction was found to be mediated through RNA binding proteins (RBPs), enabling a receptor-specific mRNA subset to be rapidly and locally translated in response to cue stimulation. …
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ΑΝΟΣΟΙΣΤΟΧΗΜΙΚΗ ΑΝΙΧΝΕΥΣΗ ΥΠΟΔΟΧΕΩΝ ΟΙΣΤΡΟΓΟΝΩΝ ΣΕ ΚΑΡΚΙΝΟ ΤΟΥ ΜΑΣΤΟΥ. ΣΥΓΚΡΙΤΙΚΗ ΜΕΛΕΤΗ
… WERE ALSO BIOCHEMICALLY TESTED FOR ER BY USING DCC METHOD. THE PRESENT IMMUNOHISTOCHEMICAL METHOD IS RELIABLE AND CAN BE EASILY PERFORMED WITHOUT SOPHISTICATED EQUIPMENT. THIS METHOD, ALONE AND ESPECIALLY IN COMBINATION WITH OTHER BIOCHEMICAL AND/OR IMMUNOHISTOCHEMICAL METHODS, CAN BE USED FOR …
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Soft pneumatic artificial muscles with low threshold pressures for a cardiac compression device
… are intended for direct cardiac compression (DCC). McKibben type PAMs typically have a threshold pressure of at least lOOkPa and require rigid end fittings which may damage soft tissue and cause local stress concentrations, and thus failure points in the actuator. The actuator design I present …
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DNA Replication of the Male X Chromosome Is Influenced by the Dosage Compensation Complex in Drosophila melanogaster
… is regulated by the dosage compensation complex (DCC), which is restricted to the X chromosome. This complex includes a histone acetyl transferase, MOF, which acetylates H4K16. This hyperacetylation allows for increased transcription of the X chromosome. </p><p>We hypothesized that the activities …
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Cellular Interactions During Motor Nerve Regeneration
… examined mutants lacking the guidance receptor DCC. We find that in DCC mutants a significant fraction of regenerating axons extend along aberrant trajectories. Collectively, this work details the dynamic activities of macrophages and Schwann cells during axon degeneration and early …
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